Fe limitation decreases transcriptional regulation over the diel cycle in the model diatom Thalassiosira pseudonana
Iron (Fe) is an important growth factor for diatoms and its availability is further restricted by changes in the carbonate chemistry of seawater. We investigated the physiological attributes and transcriptional profiles of the diatom Thalassiosira pseudonana grown on a day: night cycle under differe...
Saved in:
Published in | PloS one Vol. 14; no. 9; p. e0222325 |
---|---|
Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
Public Library of Science
11.09.2019
Public Library of Science (PLoS) |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Iron (Fe) is an important growth factor for diatoms and its availability is further restricted by changes in the carbonate chemistry of seawater. We investigated the physiological attributes and transcriptional profiles of the diatom Thalassiosira pseudonana grown on a day: night cycle under different CO2/pH and iron concentrations, that in combination generated available iron (Fe') concentrations of 1160, 233, 58 and 12 pM. We found the light-dark conditions to be the main driver of transcriptional patterns, followed by Fe' concentration and CO2 availability, respectively. At the highest Fe' (1160 pM), 55% of the transcribed genes were differentially expressed between day and night, whereas at the lowest Fe' (12 pM), only 28% of the transcribed genes displayed comparable patterns. While Fe limitation disrupts the diel expression patterns for genes in most central metabolism pathways, the diel expression of light- signaling molecules and glycolytic genes was relatively robust in response to reduced Fe'. Moreover, we identified a non-canonical splicing of transcripts encoding triose-phosphate isomerase, a key-enzyme of glycolysis, generating transcript isoforms that would encode proteins with and without an active site. Transcripts that encoded an active enzyme maintained a diel expression at low Fe', while transcripts that encoded the non-active enzyme lost the diel expression. This work illustrates the interplay between nutrient limitation and transcriptional regulation over the diel cycle. Considering that future ocean conditions will reduce the availability of Fe in many parts of the oceans, our work identifies some of the regulatory mechanisms that may shape future ecological communities. |
---|---|
AbstractList | Iron (Fe) is an important growth factor for diatoms and its availability is further restricted by changes in the carbonate chemistry of seawater. We investigated the physiological attributes and transcriptional profiles of the diatom Thalassiosira pseudonana grown on a day: night cycle under different CO2/pH and iron concentrations, that in combination generated available iron (Fe') concentrations of 1160, 233, 58 and 12 pM. We found the light-dark conditions to be the main driver of transcriptional patterns, followed by Fe' concentration and CO2 availability, respectively. At the highest Fe' (1160 pM), 55% of the transcribed genes were differentially expressed between day and night, whereas at the lowest Fe' (12 pM), only 28% of the transcribed genes displayed comparable patterns. While Fe limitation disrupts the diel expression patterns for genes in most central metabolism pathways, the diel expression of light- signaling molecules and glycolytic genes was relatively robust in response to reduced Fe'. Moreover, we identified a non-canonical splicing of transcripts encoding triose-phosphate isomerase, a key-enzyme of glycolysis, generating transcript isoforms that would encode proteins with and without an active site. Transcripts that encoded an active enzyme maintained a diel expression at low Fe', while transcripts that encoded the non-active enzyme lost the diel expression. This work illustrates the interplay between nutrient limitation and transcriptional regulation over the diel cycle. Considering that future ocean conditions will reduce the availability of Fe in many parts of the oceans, our work identifies some of the regulatory mechanisms that may shape future ecological communities. Iron (Fe) is an important growth factor for diatoms and its availability is further restricted by changes in the carbonate chemistry of seawater. We investigated the physiological attributes and transcriptional profiles of the diatom Thalassiosira pseudonana grown on a day: night cycle under different CO.sub.2 /pH and iron concentrations, that in combination generated available iron (Fe') concentrations of 1160, 233, 58 and 12 pM. We found the light-dark conditions to be the main driver of transcriptional patterns, followed by Fe' concentration and CO.sub.2 availability, respectively. At the highest Fe' (1160 pM), 55% of the transcribed genes were differentially expressed between day and night, whereas at the lowest Fe' (12 pM), only 28% of the transcribed genes displayed comparable patterns. While Fe limitation disrupts the diel expression patterns for genes in most central metabolism pathways, the diel expression of light- signaling molecules and glycolytic genes was relatively robust in response to reduced Fe'. Moreover, we identified a non-canonical splicing of transcripts encoding triose-phosphate isomerase, a key-enzyme of glycolysis, generating transcript isoforms that would encode proteins with and without an active site. Transcripts that encoded an active enzyme maintained a diel expression at low Fe', while transcripts that encoded the non-active enzyme lost the diel expression. This work illustrates the interplay between nutrient limitation and transcriptional regulation over the diel cycle. Considering that future ocean conditions will reduce the availability of Fe in many parts of the oceans, our work identifies some of the regulatory mechanisms that may shape future ecological communities. Iron (Fe) is an important growth factor for diatoms and its availability is further restricted by changes in the carbonate chemistry of seawater. We investigated the physiological attributes and transcriptional profiles of the diatom Thalassiosira pseudonana grown on a day: night cycle under different CO 2 /pH and iron concentrations, that in combination generated available iron (Fe’) concentrations of 1160, 233, 58 and 12 pM. We found the light-dark conditions to be the main driver of transcriptional patterns, followed by Fe’ concentration and CO 2 availability, respectively. At the highest Fe’ (1160 pM), 55% of the transcribed genes were differentially expressed between day and night, whereas at the lowest Fe’ (12 pM), only 28% of the transcribed genes displayed comparable patterns. While Fe limitation disrupts the diel expression patterns for genes in most central metabolism pathways, the diel expression of light- signaling molecules and glycolytic genes was relatively robust in response to reduced Fe’. Moreover, we identified a non-canonical splicing of transcripts encoding triose-phosphate isomerase, a key-enzyme of glycolysis, generating transcript isoforms that would encode proteins with and without an active site. Transcripts that encoded an active enzyme maintained a diel expression at low Fe’, while transcripts that encoded the non-active enzyme lost the diel expression. This work illustrates the interplay between nutrient limitation and transcriptional regulation over the diel cycle. Considering that future ocean conditions will reduce the availability of Fe in many parts of the oceans, our work identifies some of the regulatory mechanisms that may shape future ecological communities. Iron (Fe) is an important growth factor for diatoms and its availability is further restricted by changes in the carbonate chemistry of seawater. We investigated the physiological attributes and transcriptional profiles of the diatom Thalassiosira pseudonana grown on a day: night cycle under different CO2/pH and iron concentrations, that in combination generated available iron (Fe') concentrations of 1160, 233, 58 and 12 pM. We found the light-dark conditions to be the main driver of transcriptional patterns, followed by Fe' concentration and CO2 availability, respectively. At the highest Fe' (1160 pM), 55% of the transcribed genes were differentially expressed between day and night, whereas at the lowest Fe' (12 pM), only 28% of the transcribed genes displayed comparable patterns. While Fe limitation disrupts the diel expression patterns for genes in most central metabolism pathways, the diel expression of light- signaling molecules and glycolytic genes was relatively robust in response to reduced Fe'. Moreover, we identified a non-canonical splicing of transcripts encoding triose-phosphate isomerase, a key-enzyme of glycolysis, generating transcript isoforms that would encode proteins with and without an active site. Transcripts that encoded an active enzyme maintained a diel expression at low Fe', while transcripts that encoded the non-active enzyme lost the diel expression. This work illustrates the interplay between nutrient limitation and transcriptional regulation over the diel cycle. Considering that future ocean conditions will reduce the availability of Fe in many parts of the oceans, our work identifies some of the regulatory mechanisms that may shape future ecological communities.Iron (Fe) is an important growth factor for diatoms and its availability is further restricted by changes in the carbonate chemistry of seawater. We investigated the physiological attributes and transcriptional profiles of the diatom Thalassiosira pseudonana grown on a day: night cycle under different CO2/pH and iron concentrations, that in combination generated available iron (Fe') concentrations of 1160, 233, 58 and 12 pM. We found the light-dark conditions to be the main driver of transcriptional patterns, followed by Fe' concentration and CO2 availability, respectively. At the highest Fe' (1160 pM), 55% of the transcribed genes were differentially expressed between day and night, whereas at the lowest Fe' (12 pM), only 28% of the transcribed genes displayed comparable patterns. While Fe limitation disrupts the diel expression patterns for genes in most central metabolism pathways, the diel expression of light- signaling molecules and glycolytic genes was relatively robust in response to reduced Fe'. Moreover, we identified a non-canonical splicing of transcripts encoding triose-phosphate isomerase, a key-enzyme of glycolysis, generating transcript isoforms that would encode proteins with and without an active site. Transcripts that encoded an active enzyme maintained a diel expression at low Fe', while transcripts that encoded the non-active enzyme lost the diel expression. This work illustrates the interplay between nutrient limitation and transcriptional regulation over the diel cycle. Considering that future ocean conditions will reduce the availability of Fe in many parts of the oceans, our work identifies some of the regulatory mechanisms that may shape future ecological communities. |
Audience | Academic |
Author | Berthiaume, Chris T Coesel, Sacha N Goldman, Johanna A L Orellana, Mónica V Schatz, Megan J Armbrust, E Virginia |
AuthorAffiliation | 3 Institute for Systems Biology, Seattle, Washington, United States of America 1 School of Oceanography, University of Washington, Seattle, Washington, United States of America 2 Polar Science Center, Applied Physics Laboratory, University of Washington, Seattle, Washington, United States of America Mount Allison University, CANADA |
AuthorAffiliation_xml | – name: Mount Allison University, CANADA – name: 2 Polar Science Center, Applied Physics Laboratory, University of Washington, Seattle, Washington, United States of America – name: 1 School of Oceanography, University of Washington, Seattle, Washington, United States of America – name: 3 Institute for Systems Biology, Seattle, Washington, United States of America |
Author_xml | – sequence: 1 givenname: Johanna A L orcidid: 0000-0002-7086-2349 surname: Goldman fullname: Goldman, Johanna A L organization: School of Oceanography, University of Washington, Seattle, Washington, United States of America – sequence: 2 givenname: Megan J orcidid: 0000-0003-4669-0740 surname: Schatz fullname: Schatz, Megan J organization: School of Oceanography, University of Washington, Seattle, Washington, United States of America – sequence: 3 givenname: Chris T orcidid: 0000-0002-0747-0123 surname: Berthiaume fullname: Berthiaume, Chris T organization: School of Oceanography, University of Washington, Seattle, Washington, United States of America – sequence: 4 givenname: Sacha N orcidid: 0000-0001-9422-8388 surname: Coesel fullname: Coesel, Sacha N organization: School of Oceanography, University of Washington, Seattle, Washington, United States of America – sequence: 5 givenname: Mónica V surname: Orellana fullname: Orellana, Mónica V organization: Institute for Systems Biology, Seattle, Washington, United States of America – sequence: 6 givenname: E Virginia orcidid: 0000-0001-7865-5101 surname: Armbrust fullname: Armbrust, E Virginia organization: School of Oceanography, University of Washington, Seattle, Washington, United States of America |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31509589$$D View this record in MEDLINE/PubMed |
BookMark | eNqNk11rFDEUhoNUbLv6D0QHBNGLXfMxmY8boRSrC4WCVm9DJjmzm5JJ1mSm2H9vpjstO9ILycUMb57znpyTnFN05LwDhF4TvCKsJJ9u_BCctKtdkleYUsoof4ZOSM3osqCYHR38H6PTGG8w5qwqihfomBGOa17VJyheQGZNZ3rZG-8yDSqAjBCzPkgXVTC7UZc2C7AZ7B7ytxCyfguZNmAzdacsZMbdK53XSdJG9r7LrrfSyhiNjybIbBdh0MnKyZfoeStthFfTd4F-Xny5Pv-2vLz6uj4_u1yqoqb9knPOGNMM07LK86aqeAtK5w1WuiybitOyYEB4q4E0uCKKAC9brDEUDZQaU7ZAb_e-O-ujmPoVBaVVjWlBGU_Eek9oL2_ELphOhjvhpRH3gg8bIUNvUoGCFJpWyZTVJJ1Bl03LmrbGDcEltDkds32esg1NB1qBSy20M9P5jjNbsfG3oihZVadLWqAPk0HwvweIvehMVGCtdOCH_bl5WZB8RN_9gz5d3URtZCrAuNanvGo0FWe8rpNRWolaPUGlpaEzKj2u1iR9FvBxFpCYHv70GznEKNY_vv8_e_Vrzr4_YLcgbb-N3g7jm4tzMN-DKvgYA7SPTSZYjLPx0A0xzoaYZiOFvTm8oMegh2FgfwHEHwwd |
CitedBy_id | crossref_primary_10_1111_mec_16703 crossref_primary_10_1186_s12864_021_07666_3 crossref_primary_10_7554_eLife_84392 crossref_primary_10_1016_j_isci_2020_101730 crossref_primary_10_1016_j_jenvman_2020_111884 crossref_primary_10_1038_s43705_022_00136_1 crossref_primary_10_1128_mSystems_00188_21 crossref_primary_10_1111_jpy_13362 crossref_primary_10_1016_j_ijbiomac_2023_126361 crossref_primary_10_1111_tpj_15291 |
Cites_doi | 10.1104/pp.113.217737 10.1073/pnas.0707692104 10.1073/pnas.1118408109 10.1111/j.1472-4669.2009.00207.x 10.1093/jxb/ert387 10.1093/bioinformatics/btp616 10.1126/science.1183517 10.1038/nature02954 10.1038/nprot.2016.095 10.1371/journal.pone.0001426 10.1016/j.algal.2012.04.003 10.1073/pnas.1300962110 10.15252/embj.201696392 10.1007/s11120-016-0330-2 10.1126/science.1131669 10.1038/382802a0 10.1146/annurev-marine-010814-015813 10.1371/journal.pgen.1006490 10.1111/j.0022-3646.1983.00522.x 10.1093/bioinformatics/btu170 10.1007/s11120-016-0282-6 10.1038/nature25982 10.1007/BF00393106 10.1038/ngeo1765 10.1080/0967026042000202127 10.1093/jxb/ers005 10.1146/annurev-marine-121211-172356 10.3389/fmicb.2012.00043 10.1105/tpc.112.106377 10.1038/nature08057 10.1371/journal.pone.0075653 10.1093/plankt/fbm002 10.1029/95GB01070 10.1126/science.1095964 10.1038/nmeth.3317 10.1371/journal.pone.0155038 10.1111/j.1529-8817.2007.00342.x 10.1073/pnas.1805243115 10.1007/BF00405456 10.1111/j.1469-8137.2010.03371.x 10.1038/nbt.3519 10.1111/jpy.12156 10.1038/embor.2009.59 |
ContentType | Journal Article |
Copyright | COPYRIGHT 2019 Public Library of Science 2019 Goldman et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2019 Goldman et al 2019 Goldman et al |
Copyright_xml | – notice: COPYRIGHT 2019 Public Library of Science – notice: 2019 Goldman et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: 2019 Goldman et al 2019 Goldman et al |
DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION IOV ISR 3V. 7QG 7QL 7QO 7RV 7SN 7SS 7T5 7TG 7TM 7U9 7X2 7X7 7XB 88E 8AO 8C1 8FD 8FE 8FG 8FH 8FI 8FJ 8FK ABJCF ABUWG AFKRA ARAPS ATCPS AZQEC BBNVY BENPR BGLVJ BHPHI C1K CCPQU D1I DWQXO FR3 FYUFA GHDGH GNUQQ H94 HCIFZ K9. KB. KB0 KL. L6V LK8 M0K M0S M1P M7N M7P M7S NAPCQ P5Z P62 P64 PATMY PDBOC PIMPY PQEST PQQKQ PQUKI PRINS PTHSS PYCSY RC3 7X8 5PM DOA |
DOI | 10.1371/journal.pone.0222325 |
DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef Gale_Opposing Viewpoints In Context Gale In Context: Science ProQuest Central (Corporate) Animal Behavior Abstracts Bacteriology Abstracts (Microbiology B) Biotechnology Research Abstracts Nursing & Allied Health Database (ProQuest) Ecology Abstracts Entomology Abstracts (Full archive) Immunology Abstracts Meteorological & Geoastrophysical Abstracts Nucleic Acids Abstracts Virology and AIDS Abstracts Agricultural Science Collection Health & Medical Collection (Proquest) ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest Pharma Collection Public Health Database (Proquest) Technology Research Database ProQuest SciTech Collection ProQuest Technology Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) Materials Science & Engineering Collection ProQuest Central (Alumni Edition) ProQuest Central Advanced Technologies & Aerospace Database (1962 - current) Agricultural & Environmental Science Collection ProQuest Central Essentials Biological Science Collection AUTh Library subscriptions: ProQuest Central Technology Collection ProQuest Natural Science Collection Environmental Sciences and Pollution Management ProQuest One Community College ProQuest Materials Science Collection ProQuest Central Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Materials Science Database Nursing & Allied Health Database (Alumni Edition) Meteorological & Geoastrophysical Abstracts - Academic ProQuest Engineering Collection Biological Sciences Agricultural Science Database Health & Medical Collection (Alumni Edition) PML(ProQuest Medical Library) Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Database Engineering Database Nursing & Allied Health Premium Advanced Technologies & Aerospace Database ProQuest Advanced Technologies & Aerospace Collection Biotechnology and BioEngineering Abstracts Environmental Science Database Materials Science Collection Publicly Available Content Database ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China Engineering Collection Environmental Science Collection Genetics Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef Agricultural Science Database Publicly Available Content Database ProQuest Central Student ProQuest Advanced Technologies & Aerospace Collection ProQuest Central Essentials Nucleic Acids Abstracts SciTech Premium Collection ProQuest Central China Environmental Sciences and Pollution Management Health Research Premium Collection Meteorological & Geoastrophysical Abstracts Natural Science Collection Biological Science Collection ProQuest Medical Library (Alumni) Engineering Collection Advanced Technologies & Aerospace Collection Engineering Database Virology and AIDS Abstracts ProQuest Biological Science Collection ProQuest One Academic Eastern Edition Agricultural Science Collection ProQuest Hospital Collection ProQuest Technology Collection Health Research Premium Collection (Alumni) Biological Science Database Ecology Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts Environmental Science Collection Entomology Abstracts Nursing & Allied Health Premium ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Environmental Science Database ProQuest Nursing & Allied Health Source (Alumni) Engineering Research Database ProQuest One Academic Meteorological & Geoastrophysical Abstracts - Academic Technology Collection Technology Research Database Materials Science Collection ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Central Genetics Abstracts ProQuest Engineering Collection Biotechnology Research Abstracts Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) Agricultural & Environmental Science Collection AIDS and Cancer Research Abstracts Materials Science Database ProQuest Materials Science Collection ProQuest Public Health ProQuest Nursing & Allied Health Source ProQuest SciTech Collection Advanced Technologies & Aerospace Database ProQuest Medical Library Animal Behavior Abstracts Materials Science & Engineering Collection Immunology Abstracts ProQuest Central (Alumni) MEDLINE - Academic |
DatabaseTitleList | MEDLINE Agricultural Science Database MEDLINE - Academic |
Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 4 dbid: 8FG name: ProQuest Technology Collection url: https://search.proquest.com/technologycollection1 sourceTypes: Aggregation Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Sciences (General) Oceanography |
DocumentTitleAlternate | Fe limitation decreases transcriptional regulation over the diel cycle in a model diatom |
EISSN | 1932-6203 |
Editor | Campbell, Douglas A. |
Editor_xml | – sequence: 1 givenname: Douglas A. surname: Campbell fullname: Campbell, Douglas A. |
ExternalDocumentID | 2289026235 oai_doaj_org_article_16d28023391d4bd7bf3bf90b107ef422 A599140404 10_1371_journal_pone_0222325 31509589 |
Genre | Research Support, U.S. Gov't, Non-P.H.S Research Support, Non-U.S. Gov't Journal Article |
GeographicLocations | United States United States--US Virginia |
GeographicLocations_xml | – name: United States – name: United States--US – name: Virginia |
GrantInformation_xml | – fundername: ; grantid: 3776 – fundername: ; grantid: NSF-MCB 1316206 |
GroupedDBID | --- 123 29O 2WC 3V. 53G 5VS 7RV 7X2 7X7 7XC 88E 8AO 8C1 8CJ 8FE 8FG 8FH 8FI 8FJ A8Z AAFWJ ABDBF ABIVO ABJCF ABUWG ACGFO ACIHN ACIWK ACPRK ADBBV ADRAZ AEAQA AENEX AFKRA AFRAH AHMBA ALIPV ALMA_UNASSIGNED_HOLDINGS AOIJS APEBS ARAPS ATCPS BAWUL BBNVY BBORY BCNDV BENPR BGLVJ BHPHI BKEYQ BPHCQ BVXVI BWKFM CCPQU CGR CS3 CUY CVF D1I D1J D1K DIK DU5 E3Z EAP EAS EBD ECM EIF EMOBN ESTFP ESX EX3 F5P FPL FYUFA GROUPED_DOAJ GX1 HCIFZ HH5 HMCUK HYE IAO IEA IHR IHW INH INR IOV IPNFZ IPY ISE ISR ITC K6- KB. KQ8 L6V LK5 LK8 M0K M1P M48 M7P M7R M7S M~E NAPCQ NPM O5R O5S OK1 P2P P62 PATMY PDBOC PIMPY PQQKQ PROAC PSQYO PTHSS PV9 PYCSY RIG RNS RPM RZL SV3 TR2 UKHRP WOQ WOW ~02 ~KM AAYXX AFPKN CITATION 7QG 7QL 7QO 7SN 7SS 7T5 7TG 7TM 7U9 7XB 8FD 8FK AZQEC C1K DWQXO FR3 GNUQQ H94 K9. KL. M7N P64 PQEST PQUKI PRINS RC3 7X8 5PM AAPBV ABPTK N95 |
ID | FETCH-LOGICAL-c692t-555333d3027844b885fecd4b0cd77b852763e15fde1b081c1e57f0d0e6be7d023 |
IEDL.DBID | RPM |
ISSN | 1932-6203 |
IngestDate | Sun Aug 06 00:15:51 EDT 2023 Fri Jul 05 11:50:30 EDT 2024 Tue Sep 17 20:44:23 EDT 2024 Sat Jul 20 16:38:54 EDT 2024 Thu Oct 10 17:41:35 EDT 2024 Thu Feb 22 23:35:10 EST 2024 Fri Feb 02 03:59:23 EST 2024 Thu Aug 01 20:38:58 EDT 2024 Thu Aug 01 19:42:38 EDT 2024 Tue Aug 20 22:05:52 EDT 2024 Fri Aug 23 02:43:06 EDT 2024 Sun Oct 13 10:00:04 EDT 2024 |
IsDoiOpenAccess | true |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 9 |
Language | English |
License | This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Creative Commons Attribution License |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c692t-555333d3027844b885fecd4b0cd77b852763e15fde1b081c1e57f0d0e6be7d023 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Competing Interests: The authors have declared that no competing interests exist. |
ORCID | 0000-0002-7086-2349 0000-0003-4669-0740 0000-0001-7865-5101 0000-0002-0747-0123 0000-0001-9422-8388 |
OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738920/ |
PMID | 31509589 |
PQID | 2289026235 |
PQPubID | 1436336 |
PageCount | e0222325 |
ParticipantIDs | plos_journals_2289026235 doaj_primary_oai_doaj_org_article_16d28023391d4bd7bf3bf90b107ef422 pubmedcentral_primary_oai_pubmedcentral_nih_gov_6738920 proquest_miscellaneous_2289576140 proquest_journals_2289026235 gale_infotracmisc_A599140404 gale_infotracacademiconefile_A599140404 gale_incontextgauss_ISR_A599140404 gale_incontextgauss_IOV_A599140404 gale_healthsolutions_A599140404 crossref_primary_10_1371_journal_pone_0222325 pubmed_primary_31509589 |
PublicationCentury | 2000 |
PublicationDate | 2019-09-11 |
PublicationDateYYYYMMDD | 2019-09-11 |
PublicationDate_xml | – month: 09 year: 2019 text: 2019-09-11 day: 11 |
PublicationDecade | 2010 |
PublicationPlace | United States |
PublicationPlace_xml | – name: United States – name: San Francisco – name: San Francisco, CA USA |
PublicationTitle | PloS one |
PublicationTitleAlternate | PLoS One |
PublicationYear | 2019 |
Publisher | Public Library of Science Public Library of Science (PLoS) |
Publisher_xml | – name: Public Library of Science – name: Public Library of Science (PLoS) |
References | M Pertea (pone.0222325.ref033) 2016; 11 MJ Behrenfeld (pone.0222325.ref007) 2013; 5 D Shi (pone.0222325.ref010) 2010; 327 FM Morel (pone.0222325.ref023) 1993 NL Fisher (pone.0222325.ref039) 2016; 129 BL Nunn (pone.0222325.ref041) 2013; 8 M Matthijs (pone.0222325.ref050) 2017; 36 BM Hopkinson (pone.0222325.ref042) 2013; 162 JD Strickland (pone.0222325.ref024) 1972 JB McQuaid (pone.0222325.ref011) 2018; 555 MD Robinson (pone.0222325.ref029) 2010; 26 Brookhaven National Lab., Dept. of Applied Science, Upton, NY (United States) (pone.0222325.ref026) 1998 AG Dickson (pone.0222325.ref025) 2007 JA Goldman (pone.0222325.ref043) 2017; 132 A Marchetti (pone.0222325.ref016) 2009; 7 F Takahashi (pone.0222325.ref047) 2007; 104 GM Hennon (pone.0222325.ref037) 2014; 50 J Levering (pone.0222325.ref032) 2016; 11 A Montsant (pone.0222325.ref031) 2007; 43 EV Armbrust (pone.0222325.ref001) 2009; 459 AE Fortunato (pone.0222325.ref046) 2016 J La Roche (pone.0222325.ref015) 1996; 382 J Morrissey (pone.0222325.ref040) 2012; 3 FA Depauw (pone.0222325.ref044) 2012; 63 D Kim (pone.0222325.ref028) 2015; 12 RH Lampe (pone.0222325.ref013) 2018; 115 PG Falkowski (pone.0222325.ref002) 2004; 305 DM Nelson (pone.0222325.ref003) 1995; 9 S Coesel (pone.0222325.ref045) 2009; 10 D Vaulot (pone.0222325.ref006) 1987; 95 MJ Huysman (pone.0222325.ref004) 2013; 25 SR Smith (pone.0222325.ref035) 2012; 1 M Ragni (pone.0222325.ref018) 2007; 29 NL Bray (pone.0222325.ref034) 2016; 34 A Rastogi (pone.0222325.ref052) 2017 R Olson (pone.0222325.ref005) 1983; 19 C Moore (pone.0222325.ref008) 2013; 6 J Ashworth (pone.0222325.ref019) 2013; 110 RF Strzepek (pone.0222325.ref014) 2004; 431 E Rayko (pone.0222325.ref030) 2010; 188 A Marchetti (pone.0222325.ref012) 2012; 109 SR Smith (pone.0222325.ref020) 2016; 12 MJ Huysman (pone.0222325.ref048) 2013; 65 KH Halsey (pone.0222325.ref038) 2015; 7 WG Sunda (pone.0222325.ref022) 2005 AM Bolger (pone.0222325.ref027) 2014; 30 T Owens (pone.0222325.ref017) 1980; 59 Z-Y Wang (pone.0222325.ref036) 1997; 9 PW Boyd (pone.0222325.ref009) 2007; 315 PG Kroth (pone.0222325.ref051) 2008 T van Oijen (pone.0222325.ref021) 2004; 39 R Annunziata (pone.0222325.ref049) 2018 |
References_xml | – volume: 162 start-page: 1142 issue: 2 year: 2013 ident: pone.0222325.ref042 article-title: Quantification of extracellular carbonic anhydrase activity in two marine diatoms and investigation of its role publication-title: Plant Physiology doi: 10.1104/pp.113.217737 contributor: fullname: BM Hopkinson – volume: 104 start-page: 19625 issue: 49 year: 2007 ident: pone.0222325.ref047 article-title: AUREOCHROME, a photoreceptor required for photomorphogenesis in stramenopiles publication-title: Proceedings of the National Academy of Sciences doi: 10.1073/pnas.0707692104 contributor: fullname: F Takahashi – volume: 109 start-page: E317 issue: 6 year: 2012 ident: pone.0222325.ref012 article-title: Comparative metatranscriptomics identifies molecular bases for the physiological responses of phytoplankton to varying iron availability publication-title: Proceedings of the National Academy of Sciences doi: 10.1073/pnas.1118408109 contributor: fullname: A Marchetti – volume: 7 start-page: 419 issue: 4 year: 2009 ident: pone.0222325.ref016 article-title: Diatom elemental and morphological changes in response to iron limitation: a brief review with potential paleoceanographic applications publication-title: Geobiology doi: 10.1111/j.1472-4669.2009.00207.x contributor: fullname: A Marchetti – volume: 65 start-page: 2573 issue: 10 year: 2013 ident: pone.0222325.ref048 article-title: Molecular regulation of the diatom cell cycle publication-title: Journal of Experimental Botany doi: 10.1093/jxb/ert387 contributor: fullname: MJ Huysman – volume: 26 start-page: 139 issue: 1 year: 2010 ident: pone.0222325.ref029 article-title: edgeR: a Bioconductor package for differential expression analysis of digital gene expression data publication-title: Bioinformatics doi: 10.1093/bioinformatics/btp616 contributor: fullname: MD Robinson – volume: 327 start-page: 676 issue: 5966 year: 2010 ident: pone.0222325.ref010 article-title: Effect of ocean acidification on iron availability to marine phytoplankton publication-title: Science doi: 10.1126/science.1183517 contributor: fullname: D Shi – year: 2016 ident: pone.0222325.ref046 article-title: Diatom phytochromes reveal the existence of far-red light based sensing in the ocean publication-title: The Plant Cell contributor: fullname: AE Fortunato – volume: 431 start-page: 689 issue: 7009 year: 2004 ident: pone.0222325.ref014 article-title: Photosynthetic architecture differs in coastal and oceanic diatoms publication-title: Nature doi: 10.1038/nature02954 contributor: fullname: RF Strzepek – volume: 11 start-page: 1650 issue: 9 year: 2016 ident: pone.0222325.ref033 article-title: Transcript-level expression analysis of RNA-seq experiments with HISAT publication-title: StringTie and Ballgown. Nature Protocols doi: 10.1038/nprot.2016.095 contributor: fullname: M Pertea – volume-title: A model for carbohydrate metabolism in the diatom Phaeodactylum tricornutum deduced from comparative whole genome analysis year: 2008 ident: pone.0222325.ref051 doi: 10.1371/journal.pone.0001426 contributor: fullname: PG Kroth – volume: 1 start-page: 2 issue: 1 year: 2012 ident: pone.0222325.ref035 article-title: Comparative analysis of diatom genomes reveals substantial differences in the organization of carbon partitioning pathways publication-title: Algal Research doi: 10.1016/j.algal.2012.04.003 contributor: fullname: SR Smith – volume: 110 start-page: 7518 issue: 18 year: 2013 ident: pone.0222325.ref019 article-title: Genome-wide diel growth state transitions in the diatom Thalassiosira pseudonana publication-title: Proceedings of the National Academy of Sciences doi: 10.1073/pnas.1300962110 contributor: fullname: J Ashworth – volume: 36 start-page: 1559 issue: 11 year: 2017 ident: pone.0222325.ref050 article-title: The transcription factor bZIP14 regulates the TCA cycle in the diatom Phaeodactylum tricornutum publication-title: The EMBO journal doi: 10.15252/embj.201696392 contributor: fullname: M Matthijs – year: 1972 ident: pone.0222325.ref024 publication-title: A practical handbook of seawater analysis contributor: fullname: JD Strickland – volume: 132 start-page: 83 issue: 1 year: 2017 ident: pone.0222325.ref043 article-title: The effects of pH and pCO 2 on photosynthesis and respiration in the diatom Thalassiosira weissflogii publication-title: Photosynthesis research doi: 10.1007/s11120-016-0330-2 contributor: fullname: JA Goldman – volume: 315 start-page: 612 issue: 5812 year: 2007 ident: pone.0222325.ref009 article-title: Mesoscale iron enrichment experiments 1993–2005: synthesis and future directions publication-title: Science doi: 10.1126/science.1131669 contributor: fullname: PW Boyd – volume-title: Principles and applications of aquatic chemistry year: 1993 ident: pone.0222325.ref023 contributor: fullname: FM Morel – volume: 382 start-page: 802 issue: 6594 year: 1996 ident: pone.0222325.ref015 article-title: Flavodoxin as an in situ marker for iron stress in phytoplankton publication-title: Nature doi: 10.1038/382802a0 contributor: fullname: J La Roche – volume: 7 start-page: 265 year: 2015 ident: pone.0222325.ref038 article-title: Phytoplankton strategies for photosynthetic energy allocation publication-title: Annual Review of Marine Science doi: 10.1146/annurev-marine-010814-015813 contributor: fullname: KH Halsey – volume: 12 start-page: e1006490 issue: 12 year: 2016 ident: pone.0222325.ref020 article-title: Transcriptional orchestration of the global cellular response of a model pennate diatom to diel light cycling under iron limitation publication-title: PLoS Genetics doi: 10.1371/journal.pgen.1006490 contributor: fullname: SR Smith – start-page: 271445 year: 2018 ident: pone.0222325.ref049 article-title: A bHLH-PAS protein regulates light-dependent diurnal rhythmic processes in the marine diatom Phaeodactylum tricornutum publication-title: bioRxiv contributor: fullname: R Annunziata – volume: 19 start-page: 522 issue: 4 year: 1983 ident: pone.0222325.ref005 article-title: Effects of photocycles and periodic ammonium supply on three marine phytoplankton species. I: Cell division patterns publication-title: Journal of Phycology doi: 10.1111/j.0022-3646.1983.00522.x contributor: fullname: R Olson – volume: 30 start-page: 2114 issue: 15 year: 2014 ident: pone.0222325.ref027 article-title: Trimmomatic: a flexible trimmer for Illumina sequence data publication-title: Bioinformatics doi: 10.1093/bioinformatics/btu170 contributor: fullname: AM Bolger – volume: 129 start-page: 183 issue: 2 year: 2016 ident: pone.0222325.ref039 article-title: Mechanisms that increase the growth efficiency of diatoms in low light publication-title: Photosynthesis Research doi: 10.1007/s11120-016-0282-6 contributor: fullname: NL Fisher – volume: 555 start-page: 534 issue: 7697 year: 2018 ident: pone.0222325.ref011 article-title: Carbonate-sensitive phytotransferrin controls high-affinity iron uptake in diatoms publication-title: Nature doi: 10.1038/nature25982 contributor: fullname: JB McQuaid – volume-title: Guide to best practices for ocean CO2 measurements year: 2007 ident: pone.0222325.ref025 contributor: fullname: AG Dickson – volume: 95 start-page: 625 issue: 4 year: 1987 ident: pone.0222325.ref006 article-title: Cell-cycle response to nutrient starvation in two phytoplankton species, Thalassiosira weissflogii and Hymenomonas carterae publication-title: Marine Biology doi: 10.1007/BF00393106 contributor: fullname: D Vaulot – volume: 6 start-page: 701 issue: 9 year: 2013 ident: pone.0222325.ref008 article-title: Processes and patterns of oceanic nutrient limitation publication-title: Nature Geoscience doi: 10.1038/ngeo1765 contributor: fullname: C Moore – volume: 39 start-page: 161 issue: 2 year: 2004 ident: pone.0222325.ref021 article-title: Effects of iron limitation on photosynthesis and carbohydrate metabolism in the Antarctic diatom Chaetoceros brevis (Bacillariophyceae) publication-title: European Journal of Phycology doi: 10.1080/0967026042000202127 contributor: fullname: T van Oijen – volume-title: Program developed for CO {sub 2} system calculations year: 1998 ident: pone.0222325.ref026 contributor: fullname: Brookhaven National Lab., Dept. of Applied Science, Upton, NY (United States) – volume: 63 start-page: 1575 issue: 4 year: 2012 ident: pone.0222325.ref044 article-title: Exploring the molecular basis of responses to light in marine diatoms publication-title: Journal of Experimental Botany doi: 10.1093/jxb/ers005 contributor: fullname: FA Depauw – volume: 5 start-page: 217 year: 2013 ident: pone.0222325.ref007 article-title: Photophysiological expressions of iron stress in phytoplankton publication-title: Annual Review of Marine Science doi: 10.1146/annurev-marine-121211-172356 contributor: fullname: MJ Behrenfeld – volume: 3 start-page: 43 year: 2012 ident: pone.0222325.ref040 article-title: Iron utilization in marine cyanobacteria and eukaryotic algae publication-title: Frontiers in microbiology doi: 10.3389/fmicb.2012.00043 contributor: fullname: J Morrissey – volume: 25 start-page: 215 issue: 1 year: 2013 ident: pone.0222325.ref004 article-title: AUREOCHROME1a-mediated induction of the diatom-specific cyclin dsCYC2 controls the onset of cell division in diatoms (Phaeodactylum tricornutum) publication-title: The Plant Cell doi: 10.1105/tpc.112.106377 contributor: fullname: MJ Huysman – start-page: 35 volume-title: Algal culturing techniques year: 2005 ident: pone.0222325.ref022 contributor: fullname: WG Sunda – volume: 459 start-page: 185 issue: 7244 year: 2009 ident: pone.0222325.ref001 article-title: The life of diatoms in the world's oceans publication-title: Nature doi: 10.1038/nature08057 contributor: fullname: EV Armbrust – volume: 8 start-page: e75653 issue: 10 year: 2013 ident: pone.0222325.ref041 article-title: Diatom proteomics reveals unique acclimation strategies to mitigate Fe limitation publication-title: PLoS One doi: 10.1371/journal.pone.0075653 contributor: fullname: BL Nunn – volume: 29 start-page: 141 issue: 2 year: 2007 ident: pone.0222325.ref018 article-title: Circadian variability in the photobiology of Phaeodactylum tricornutum: pigment content publication-title: Journal of Plankton Research doi: 10.1093/plankt/fbm002 contributor: fullname: M Ragni – start-page: 176024 year: 2017 ident: pone.0222325.ref052 article-title: Integrative analysis of large scale transcriptome data draws a comprehensive landscape of Phaeodactylum tricornutum functional genome and evolutionary origin of diatoms publication-title: bioRxiv contributor: fullname: A Rastogi – volume: 9 start-page: 359 issue: 3 year: 1995 ident: pone.0222325.ref003 article-title: Production and dissolution of biogenic silica in the ocean: revised global estimates, comparison with regional data and relationship to biogenic sedimentation publication-title: Global Biogeochemical Cycles doi: 10.1029/95GB01070 contributor: fullname: DM Nelson – volume: 9 start-page: 491 issue: 4 year: 1997 ident: pone.0222325.ref036 article-title: A Myb-related transcription factor is involved in the phytochrome regulation of an Arabidopsis Lhcb gene publication-title: The Plant Cell Online contributor: fullname: Z-Y Wang – volume: 305 start-page: 354 issue: 5682 year: 2004 ident: pone.0222325.ref002 article-title: The evolution of modern eukaryotic phytoplankton publication-title: Science doi: 10.1126/science.1095964 contributor: fullname: PG Falkowski – volume: 12 start-page: 357 issue: 4 year: 2015 ident: pone.0222325.ref028 article-title: HISAT: a fast spliced aligner with low memory requirements publication-title: Nature methods doi: 10.1038/nmeth.3317 contributor: fullname: D Kim – volume: 11 start-page: e0155038 issue: 5 year: 2016 ident: pone.0222325.ref032 article-title: Genome-scale model reveals metabolic basis of biomass partitioning in a model diatom publication-title: PLoS One doi: 10.1371/journal.pone.0155038 contributor: fullname: J Levering – volume: 43 start-page: 585 issue: 3 year: 2007 ident: pone.0222325.ref031 article-title: Identification and comparative genomic analysis of signaling and regulatory components in the diatom Thalassiosira pseudonana publication-title: Journal of Phycology doi: 10.1111/j.1529-8817.2007.00342.x contributor: fullname: A Montsant – volume: 115 start-page: E12275 issue: 52 year: 2018 ident: pone.0222325.ref013 article-title: Different iron storage strategies among bloom-forming diatoms publication-title: Proceedings of the National Academy of Sciences doi: 10.1073/pnas.1805243115 contributor: fullname: RH Lampe – volume: 59 start-page: 71 issue: 2 year: 1980 ident: pone.0222325.ref017 article-title: Diel periodicity in cellular chlorophyll content in marine diatoms publication-title: Marine Biology doi: 10.1007/BF00405456 contributor: fullname: T Owens – volume: 188 start-page: 52 issue: 1 year: 2010 ident: pone.0222325.ref030 article-title: Transcription factor families inferred from genome sequences of photosynthetic stramenopiles publication-title: New Phytologist doi: 10.1111/j.1469-8137.2010.03371.x contributor: fullname: E Rayko – volume: 34 start-page: 525 issue: 5 year: 2016 ident: pone.0222325.ref034 article-title: Near-optimal probabilistic RNA-seq quantification publication-title: Nature Biotechnology doi: 10.1038/nbt.3519 contributor: fullname: NL Bray – volume: 50 start-page: 243 issue: 2 year: 2014 ident: pone.0222325.ref037 article-title: Acclimation conditions modify physiological response of the diatom Thalassiosira pseudonana to elevated CO2 concentrations in a nitrate‐limited chemostat publication-title: Journal of Phycology doi: 10.1111/jpy.12156 contributor: fullname: GM Hennon – volume: 10 start-page: 655 issue: 6 year: 2009 ident: pone.0222325.ref045 article-title: Diatom PtCPF1 is a new cryptochrome/photolyase family member with DNA repair and transcription regulation activity publication-title: EMBO reports doi: 10.1038/embor.2009.59 contributor: fullname: S Coesel |
SSID | ssj0053866 |
Score | 2.4121714 |
Snippet | Iron (Fe) is an important growth factor for diatoms and its availability is further restricted by changes in the carbonate chemistry of seawater. We... |
SourceID | plos doaj pubmedcentral proquest gale crossref pubmed |
SourceType | Open Website Open Access Repository Aggregation Database Index Database |
StartPage | e0222325 |
SubjectTerms | Analysis Availability Biology and Life Sciences Carbon dioxide Carbonates Cell cycle Cell division Diatoms Diatoms - genetics Diatoms - metabolism Earth Sciences Ecology and Environmental Sciences Enzymes Experiments Gene expression Gene Expression Regulation - genetics Gene regulation Genes Genetic aspects Genetic regulation Genomes Glucose metabolism Glycolysis Growth Growth factors Influence Iron Iron (Nutrient) Iron - metabolism Isoforms Laboratories Light effects Metabolism Monosaccharides Night Nutrient cycles Oceanography Oceans Organic chemistry Phosphates Photoperiod Photosynthesis Physical Sciences Physiological aspects Physiology Proteins Regulatory mechanisms (biology) Seawater Splicing Thalassiosira pseudonana Transcription Transcription (Genetics) Transcription factors Transcriptome - genetics Triose-phosphate isomerase |
SummonAdditionalLinks | – databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwELbQnrggyquBBQxCAg5p48TO41gQq4IESNCi3qL41UZaktV699B_3xk7WW1QJThwjUeTZGY8_kaeByFvRNYU1qYstrJIY66UjuEYKeNGN1kl07JsfJOkr9_y03P-5UJc7I36wpyw0B44CO6Y5TrFJmVZxTSXupA2k7ZKJIQtxvI0eF8mxmAq-GDYxXk-FMplBTse9HK06jtzhCFOhqOx9w4i369_55Vnq2XvboOcf2ZO7h1Fi_vk3oAh6Un49gNyx3QPyMGwSx19N7SSfv-QuIWhSyxh8vKn2mNEBzQbPKJGhwG81mEkPRJhTicFWEh1a5ZUXcMraNv5J35sDsXZHv1venaFJZiu7V27bujKma0GVl3ziJwvPp19PI2HMQuxyqt0EwsBkC_Tmb-D5LIshTUKZJ0oXRSyFCm4IMOE1YZJABCKGVHYRCcml6bQoJrHZNaBYA8JNUoyZgVXKRccvCjwKDVngOKQnUkiEo8yr1ehm0btr9QKiEKC8GrUUT3oKCIfUDE7WuyF7R-AhdSDhdR_s5CIvES11qGwdLej6xMB2JiDE-MRee0psB9Ghwk3l83Wufrz91__QPTzx4To7UBke9CkaoYiB_gn7LM1oZxPKGFXq8nyIRrhKBVXp_5GGMAqCGU-Gubty692y8gUk-g6028DDYSX8IKIPAl2vJNsBoFBJcoqIsXEwiein6507ZVvR45zY6s0efo_dPWM3AVE6pP4GJuT2Wa9Nc8B9W3kC7_BbwDdhVXY priority: 102 providerName: Directory of Open Access Journals – databaseName: Public Health Database (Proquest) dbid: 8C1 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1Lb9QwELZguSAkRMujKQUMQgIOaWPHzuOESsWqIEElaFFvUfxqV1qS7Wb3wL9nxvGGBlWIazyZJJ6Hv4nHM4S8lmmdO8dZ7FTOY6G1iWEZKeLa1GmpeFHUvkjSl6_Z8Zn4fC7Pww-3LqRVbnyid9Sm1fiP_ID7HTFYrOX7xVWMXaNwdzW00LhN7jBQTGzdUBwNKR5gy1kWjsulOTsI0tlftI3dx0AnxQbZ15YjX7V_8M2TxbztbgKef-dPXluQpg_I_YAk6WEv-i1yyzbb5N6JtnUTylBvk61guh19G-pLv3tIuqmlczzX5IVCjQeOHdCscN3aeBFgvez71CMRJnpSwIrUzOyc6l_wRDpr_BXfS4diw4_2Jz29xHOZ3aztZsuaLjq7NsCqqR-Rs-nH06PjOPReiHVW8lUsJeDA1KR-Y1KoopDOaiNUok2eq0Jy8EuWSWcsU4AqNLMyd4lJbKZsbgAIPCaTBuZ5h1CrFWNOCs2FFOBagUdhBANoh-xsEpF4I4Jq0ZfYqPw-Ww6hST-XFYqsCiKLyAeU00CLBbL9hXZ5UQV7q1hmONa2S0sGb21y5VLlykRBtGud4DwiL1DKVX_adDDz6lACYBbg2UREXnkKLJLRYBbORb3uuurTyY__IPr-bUT0JhC5FiSp63DyAb4Ji2-NKPdGlGDqejS8gzq5mZWu-mMUcOdGT28efjkMI1PMrGtsu-5pIOaEB0TkSa_Ww8ymEC2Usigjko8UfjT145FmdulrlGMz2ZInu_9-rafkLgBQn7PH2B6ZrJZr-wxA3ko995b8G_B4Unc priority: 102 providerName: ProQuest – databaseName: Scholars Portal Journals: Open Access dbid: M48 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3db9MwELdGeeEFMb4WKGAQEvCQKnbsJnlAaCCqgTSQYEV7i-LY3iKVpNStxP577pwPEVSkvcbXS3Nf_p18viPkpYyLxFrOQqsSHoqy1CFsI2lY6CLOFE_TwjdJOv0yP1mKz-fy_ID0M1s7Abq9qR3Ok1puVrPfv67egcO_9VMbEtb_aLZuajPDBCbm8ga5yUUs0OZPxXCuAN7tTy8RtYRzHsXdZbr_cRltVr6n_xC5J-tV4_bB0n-rK__arhZ3yO0OZ9Lj1jAOyYGp75LDzpMdfd21m35zj7iFoSu85uR1RLXHkQ5otriN9UEFeG3asfVIhHWfFKAj1ZVZ0fIKXkGr2j_xo3Uozv9oftKzS7ym6arGVZuCrp3ZaWBVF_fJcvHx7MNJ2I1iCMt5xrehlAALYx37c0qh0lRaU2qholIniUolhzBlmLTaMAUgo2RGJjbSkZkrk2jABQ_IpAbBHhFqSsWYlaLkQgqItMAj1YIB0kN2JgpI2Ms8X7cdN3J_7JZAptIKL0cd5Z2OAvIeFTPQYr9s_6DZXOSd--Vsrjm2uoszBv9aJ8rGymaRguTXWMF5QJ6hWvP28ung9fmxBPwsINCJgLzwFNgzo8ainIti51z-6euPaxB9_zYietUR2QY0WRbdRQj4JuzFNaKcjijB88vR8hEaYS8Vl3N_agyAFoQy7Q1z__LzYRmZYqFdbZpdSwMpKLwgIA9bOx4kG0PykMk0C0gysvCR6McrdXXpW5bjbNmMR4-u_emPyS2Apr6aj7EpmWw3O_ME4N9WPfUe_QdKCFl- priority: 102 providerName: Scholars Portal |
Title | Fe limitation decreases transcriptional regulation over the diel cycle in the model diatom Thalassiosira pseudonana |
URI | https://www.ncbi.nlm.nih.gov/pubmed/31509589 https://www.proquest.com/docview/2289026235 https://www.proquest.com/docview/2289576140/abstract/ https://pubmed.ncbi.nlm.nih.gov/PMC6738920 https://doaj.org/article/16d28023391d4bd7bf3bf90b107ef422 http://dx.doi.org/10.1371/journal.pone.0222325 |
Volume | 14 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3Nb9MwFLe2cuGCGF_LKMUgJOCQNnbsOD1uVctA6pjGhnqL4o9skdqkatoDF_52np2kWtAOiIsP8YuTvOf3_HP8PhD6wMNUZBklfiYF9ZlS2odlJPZTnYZjSeM4dUmS5hfR-Q37tuCLA8TbWBjntK9kPiyWq2GR3znfyvVKjVo_sdHlfGIrVY5pMDpEhyIM2y16bX5BgaOoiZELBRk1Ihmuy8IM7e4mpLZaTQhAaMxtcfd7y5HL2r-3zb31sqweAp5_-0_eW5BmT9GTBkni0_qNj9CBKZ6ho0ZXK_ypSSj9-TmqZgYvbSCTkwLWDilWQLO1C1VrNmCsTV2Y3hJZz04M4BDr3Cyx-gWPwHnhrrjiOdhW-ChX-PrOBmJWeVnlmxSvK7PTMFSRvkA3s-n15Nxvii34KhrTrc85AL9Qh-4kksk45plRmslAaSFkzCkYIkN4pg2RACMUMVxkgQ5MJI3QsPK_RL0CeHyMsFGSkIwzRRlnYEthjFgzAljODmcCD_ktz5N1nVMjcQdrAvYiNfMSK66kEZeHzqxg9rQ2I7a7UG5uk2ZeJCTS1CazC8cE3loLmYUyGwcStrcmY5R66K0Va1KHl-71OjnlgJAZmDLmofeOwmbFKKzbzW26q6rk6_ef_0D046pD9LEhykqQpEqbUAf4Jpttq0PZ71CCbqtO97GdhC1XqoS6c2GArMCUfjsxH-5-t--2g1pXusKUu5oGNpnwAA-9qufxnrOtVnhIdGZ4h_XdHtBRl5S80cmT_77zNXoMYNT57xHSR73tZmfeAODbygGo-UJAG0-IbWdfBujR2fTi8mrgfqFAO2exbX9PB84Y_AG67l3z |
link.rule.ids | 230,315,733,786,790,870,891,2115,2236,12083,12250,12792,21416,24346,27955,27956,31752,31753,33299,33300,33406,33407,33777,33778,43343,43612,43633,43838,53825,53827,74100,74369,74390,74657 |
linkProvider | National Library of Medicine |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1Lb9QwELZgewAhIVoeDRRqEBJwSBsncR4n1KKuttBuUdmi3qL41a60JMtm98C_Z8ZxlgZViGs8cRKPZ_xNPP6GkLc8KlNjQuYbkYZ-LKXyYRnJ_FKVUS7CLCstSdLpOBldxJ8v-aX74da4tMrOJ1pHrWqJ_8j3Q7sjBos1_zj_6WPVKNxddSU07pINpNzMBmTj8Gj89bzzxWDNSeIOzEUp23f62ZvXld7DUCfCEtk3FiTL27_2zoP5rG5ug55_Z1DeWJKGj8hDhyXpQav8TXJHV1vkwZnUZeWIqLfIpjPehr53DNMfHpNmqOkMTzZZtVBloWMDMktcuTo_Al0v2kr1KISpnhTQIlVTPaPyFzyRTit7xVbToVjyo_5BJ9d4MrOZ1s10UdJ5o1cKuqrKJ-RieDT5NPJd9QVfJnm49DkHJBipyG5NxiLLuNFSxSKQKk1FxkPwTJpxozQTgCsk0zw1gQp0InSqAAo8JYMKxnmbUC0FY4bHMox5DM4V-shUzADcYXc68IjfqaCYtyQbhd1pSyE4aceyQJUVTmUeOUQ9rWWRItteqBdXhbO4giUqRHa7KGfw1ioVJhImDwTEu9rEYeiRXdRy0Z43XRt6ccABMsfg22KPvLESSJNRYR7OVblqmuL47Pt_CH077wm9c0KmBk3K0p19gG9C-q2e5E5PEoxd9pq3cU52o9IUf8wC7uzm6e3Nr9fN2Cnm1lW6XrUyEHXCAzzyrJ3W65GNIF7IeZZ7JO1N-N7Q91uq6bVlKcdysnkYPP_3a-2Se6PJ6Ulxcjz-8oLcBzhqM_gY2yGD5WKlXwLkW4pXzq5_Azr4Vws |
linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1Zb9QwELZgkRBCQrQcDRRqEBLwkG6cxDmeUDmWlqNF0KK-RfHVrrQky3r3gX_PjOMsDaoQr_FkkngOf47nIOQZT-rcmJiFRuRxmEqpQlhGirBWdVKKuChqVyTp82G2f5J-OOWnPv7J-rDK3ic6R61aif_Ix7E7EYPFmo-ND4v48nbyav4zxA5SeNLq22lcJdcQZGMbh2LyvvfKYNdZ5lPnkpyNvaR2522jd3HTk2Cz7AtLk6vgv_bTo_mstZeB0L9jKS8sTpPb5JZHlXSvU4MNckU3m-TmkdR140tSb5INb8aWvvC1pl_eIXai6QxznJyAqHIg0gLNEtew3qMA60XXsx6JMOiTAm6kaqpnVP6CJ9Jp4664vjoUm3-0P-jxOeZo2mlrp4uazq1eKWDV1HfJyeTd8Zv90PdhCGVWxsuQc8CEiUrcIWUqioIbLVUqIqnyXBQ8Bh-lGTdKMwEIQzLNcxOpSGdC5wpAwT0yamCetwjVUjBmeCrjlKfgZoFHoVIGMA_Z6SggYS-Cat6V26jcmVsO25RuLisUWeVFFpDXKKc1LRbLdhfaxVnlba9imYqxzl1SMnhrlQuTCFNGAna-2qRxHJAdlHLVZZ6uTb7a4wCeU_ByaUCeOgosmNGg6p3VK2urg6Pv_0H07euA6LknMi1IUtY-CwK-CQtxDSi3B5Rg9nIwvIU62c-Krf4YCNzZ6-nlw0_Ww8gUo-wa3a46Gth_wgMCcr9T6_XMJrBzKHlRBiQfKPxg6ocjzfTc1SvHxrJlHD3492vtkOtg0NWng8OPD8kNwKUulI-xbTJaLlb6EWC_pXjsjPo3mxhZ0Q |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Fe+limitation+decreases+transcriptional+regulation+over+the+diel+cycle+in+the+model+diatom+Thalassiosira+pseudonana&rft.jtitle=PloS+one&rft.au=Goldman%2C+Johanna+A.+L&rft.au=Schatz%2C+Megan+J&rft.au=Berthiaume%2C+Chris+T&rft.au=Coesel%2C+Sacha+N&rft.date=2019-09-11&rft.pub=Public+Library+of+Science&rft.issn=1932-6203&rft.eissn=1932-6203&rft.volume=14&rft.issue=9&rft.spage=e0222325&rft_id=info:doi/10.1371%2Fjournal.pone.0222325&rft.externalDocID=A599140404 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1932-6203&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1932-6203&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1932-6203&client=summon |