A genome-wide association study identifies novel candidate genes for susceptibility to diabetes mellitus in non-obese cats

• Published in: PloS one Vol. 16; no. 12; p. e0259939
• Main Authors: Forcada, Yaiza, Boursnell, Mike, Catchpole, Brian, Church, David B
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 07.12.2021; Public Library of Science (PLoS)
• Subjects: Animals; Beta cells; Biology and Life Sciences; Case-Control Studies; Cat Diseases - genetics; Cats; Chromosome Mapping; Chromosomes; Data analysis; Deoxyribonucleic acid; Diabetes; Diabetes mellitus; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus - genetics; Diabetes Mellitus - veterinary; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases - genetics; Disease; Disease susceptibility; DNA; Domestic animals; Endocrine disorders; Environmental factors; Epigenetics; Evaluation; Female; Gene polymorphism; Genes; Genetic Predisposition to Disease; Genetic testing; Genome-wide association studies; Genome-Wide Association Study - veterinary; Genomes; Haplotypes; Health aspects; Health risk assessment; Hyperglycemia; Inactivation; Insulin; Insulin resistance; Insulin-like growth factors; Lipids; Male; Medicine and Health Sciences; Membrane Proteins - genetics; Metabolism; Obesity; Peptidase; Peptidases; Polymorphism; Polymorphism, Single Nucleotide; Population; Population structure; Protein Tyrosine Phosphatases - genetics; Quality control; Risk factors; Single-nucleotide polymorphism; Steroids; Veterinary colleges; United Kingdom; United Kingdom > UK; Australia; United States > US

Diabetes mellitus (DM) is a common feline endocrinopathy, which is similar to human type 2 diabetes (T2DM) in terms of its pathophysiology. T2DM occurs due to peripheral insulin resistance and/or β-cell dysfunction. Several studies have identified genetic and environmental factors that contribute to...