Aryl hydrocarbon receptor downregulates MYCN expression and promotes cell differentiation of neuroblastoma

• Published in: PloS one Vol. 9; no. 2; p. e88795
• Main Authors: Wu, Pei-Yi, Liao, Yung-Feng, Juan, Hsueh-Fen, Huang, Hsuan-Cheng, Wang, Bo-Jeng, Lu, Yen-Lin, Yu, I-Shing, Shih, Yu-Yin, Jeng, Yung-Ming, Hsu, Wen-Ming, Lee, Hsinyu
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 21.02.2014; Public Library of Science (PLoS)
• Subjects: Amplification; Analysis; Apoptosis; Aromatic compounds; Biology; Blotting, Western; Cancer; Cell cycle; Cell differentiation; Cell Differentiation - physiology; Cell growth; Cell Line, Tumor; Computational Biology; Copy number; Differentiation (biology); Dioxin; Dioxins; DNA microarrays; DNA Primers - genetics; Ectopic expression; Gene expression; Gene Expression Regulation, Neoplastic - physiology; Gene regulation; Genes; Hospitals; Humans; Hydrocarbons; Life sciences; Luciferases; Medical prognosis; Medical research; Medicine; Mortality; MYCN gene; N-Myc Proto-Oncogene Protein; Neuroblastoma; Neuroblastoma - physiopathology; Nuclear Proteins - metabolism; Oligonucleotides; Oligonucleotides - genetics; Oncogene Proteins - metabolism; Prognosis; Real-Time Polymerase Chain Reaction; Receptors, Aryl Hydrocarbon - metabolism; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Statistics, Nonparametric; Tissue Array Analysis; Tissues; Transcription; Tumorigenesis; Tumors; Taiwan

Neuroblastoma (NB) is the most common malignant disease of infancy. MYCN amplification is a prognostic factor for NB and is a sign of highly malignant disease and poor patient prognosis. In this study, we aimed to investigate novel MYCN-related genes and assess how they affect NB cell behavior. The...