Avidity-dependent programming of autoreactive T cells in T1D

• Published in: PloS one Vol. 9; no. 5; p. e98074
• Main Authors: Durinovic-Belló, Ivana, Gersuk, Vivian H, Ni, Chester, Wu, Rebecca, Thorpe, Jerill, Jospe, Nicholas, Sanda, Srinath, Greenbaum, Carla J, Nepom, Gerald T
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 20.05.2014; Public Library of Science (PLoS)
• Subjects: Adult; Antigens; Autoantigens - immunology; Autoimmunity; Avidity; Biology and Life Sciences; Case-Control Studies; Cell fate; Diabetes; Diabetes mellitus; Diabetes mellitus (insulin dependent); Diabetes Mellitus, Type 1 - immunology; Female; Gene expression; Gene Expression Profiling; Genes; Genotype; Genotypes; Histocompatibility antigen HLA; Humans; Insulin; Insulin - genetics; Insulin - immunology; Lymphocytes; Lymphocytes T; Male; Middle Aged; Peptides; Proinsulin - genetics; Proinsulin - immunology; Proinsulin - metabolism; Protein Binding; Receptors, Antigen, T-Cell; Signal strength; T cell receptors; T cells; T-Cell Antigen Receptor Specificity - immunology; T-cell receptor; T-Lymphocyte Subsets - immunology; T-Lymphocyte Subsets - metabolism; Thymus; Transcription; Translators; Type 1 diabetes; Young Adult; United States > US; Virginia

Fate determination for autoreactive T cells relies on a series of avidity-dependent interactions during T cell selection, represented by two general types of signals, one based on antigen expression and density during T cell development, and one based on genes that interpret the avidity of TCR inter...