Genetic Polymorphisms of Stromal Interaction Molecule 1 Associated with the Erythrocyte Sedimentation Rate and C-Reactive Protein in HLA-B27 Positive Ankylosing Spondylitis Patients

Ankylosing spondylitis (AS) is a chronic inflammation of the sacroiliac joints, spine and peripheral joints. The development of ankylosing spondylitis is still unclear. Genetics factors such as human leukocyte antigen HLA-B27 and ERAP1 have been widely reported to associate to AS susceptibility. In...

Full description

Saved in:
Bibliographic Details
Published inPloS one Vol. 7; no. 12; p. e49698
Main Authors Wei, James Cheng-Chung, Hung, Kuo-Sheng, Hsu, Yu-Wen, Wong, Ruey-Hong, Huang, Chun-Huang, Jan, Ming-Shiou, Wu, Shyh-Jong, Juan, Yung-Shun, Chang, Wei-Chiao
Format Journal Article
LanguageEnglish
Published United States Public Library of Science 14.12.2012
Public Library of Science (PLoS)
Subjects
Adolescent
Adult
Aged
Alleles
Ankylosing spondylitis
Antigens
Arthritis
B cells
Biology
Blood Sedimentation
C-reactive protein
C-Reactive Protein - genetics
Deoxyribonucleic acid
DNA
Enzymes
Erythrocyte sedimentation rate
Erythrocytes
Genes
Genetic aspects
Genetics
Genotype
Haplotypes
Histocompatibility antigen HLA
HLA antigens
HLA-B27 Antigen - biosynthesis
Homozygote
Hospitals
Humans
Immunology
Inflammation
Interleukin-6 - metabolism
Joint diseases
Laboratories
Leukocytes
Medical research
Medical schools
Medicine
Membrane Proteins - genetics
Membrane Proteins - metabolism
Middle Aged
Neoplasm Proteins - genetics
Neoplasm Proteins - metabolism
Nucleotides
Pathogenesis
Patients
Pharmacy
Polymorphism, Genetic
Polymorphism, Single Nucleotide
Proteins
Sequence Analysis, DNA
Severity of Illness Index
Single nucleotide polymorphisms
Single-nucleotide polymorphism
Spine
Spondylitis
Spondylitis, Ankylosing - diagnosis
Spondylitis, Ankylosing - genetics
STIM1 protein
Stromal Interaction Molecule 1
Studies
Tagging
Tumor Necrosis Factor-alpha - metabolism
Tumor necrosis factor-TNF
Taiwan
Online AccessGet full text

Cover

Abstract Ankylosing spondylitis (AS) is a chronic inflammation of the sacroiliac joints, spine and peripheral joints. The development of ankylosing spondylitis is still unclear. Genetics factors such as human leukocyte antigen HLA-B27 and ERAP1 have been widely reported to associate to AS susceptibility. In this study, we enrolled 361 AS patients and selected four tagging single nucleotides polymorphisms (tSNPs) at STIM1 gene. The correlation between STIM1 genetic polymorphisms and AS activity index (BASDAI, BASFI, BAS-G) as well as laboratory parameters of inflammation (erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP)) were tested. Our results indicated that HLA-B27 positive AS patients who are carrying the minor allele homozygous G/G genotype of SNP rs3750996 significantly associated with a higher level of ESR in serum. Furthermore, rs3750996/rs3750994 pairwise allele analysis indicated that G-C haplotypes also significantly correlated with higher level of ESR as well as CRP. These findings provide a better understanding of STIM1 genetic contribution to the pathogenesis of AS.
AbstractList Ankylosing spondylitis (AS) is a chronic inflammation of the sacroiliac joints, spine and peripheral joints. The development of ankylosing spondylitis is still unclear. Genetics factors such as human leukocyte antigen HLA-B27 and ERAP1 have been widely reported to associate to AS susceptibility. In this study, we enrolled 361 AS patients and selected four tagging single nucleotides polymorphisms (tSNPs) at STIM1 gene. The correlation between STIM1 genetic polymorphisms and AS activity index (BASDAI, BASFI, BAS-G) as well as laboratory parameters of inflammation (erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP)) were tested. Our results indicated that HLA-B27 positive AS patients who are carrying the minor allele homozygous G/G genotype of SNP rs3750996 significantly associated with a higher level of ESR in serum. Furthermore, rs3750996/rs3750994 pairwise allele analysis indicated that G-C haplotypes also significantly correlated with higher level of ESR as well as CRP. These findings provide a better understanding of STIM1 genetic contribution to the pathogenesis of AS.
Ankylosing spondylitis (AS) is a chronic inflammation of the sacroiliac joints, spine and peripheral joints. The development of ankylosing spondylitis is still unclear. Genetics factors such as human leukocyte antigen HLA-B27 and ERAP1 have been widely reported to associate to AS susceptibility. In this study, we enrolled 361 AS patients and selected four tagging single nucleotides polymorphisms (tSNPs) at STIM1 gene. The correlation between STIM1 genetic polymorphisms and AS activity index (BASDAI, BASFI, BAS-G) as well as laboratory parameters of inflammation (erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP)) were tested. Our results indicated that HLA-B27 positive AS patients who are carrying the minor allele homozygous G/G genotype of SNP rs3750996 significantly associated with a higher level of ESR in serum. Furthermore, rs3750996/rs3750994 pairwise allele analysis indicated that G-C haplotypes also significantly correlated with higher level of ESR as well as CRP. These findings provide a better understanding of STIM1 genetic contribution to the pathogenesis of AS.Ankylosing spondylitis (AS) is a chronic inflammation of the sacroiliac joints, spine and peripheral joints. The development of ankylosing spondylitis is still unclear. Genetics factors such as human leukocyte antigen HLA-B27 and ERAP1 have been widely reported to associate to AS susceptibility. In this study, we enrolled 361 AS patients and selected four tagging single nucleotides polymorphisms (tSNPs) at STIM1 gene. The correlation between STIM1 genetic polymorphisms and AS activity index (BASDAI, BASFI, BAS-G) as well as laboratory parameters of inflammation (erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP)) were tested. Our results indicated that HLA-B27 positive AS patients who are carrying the minor allele homozygous G/G genotype of SNP rs3750996 significantly associated with a higher level of ESR in serum. Furthermore, rs3750996/rs3750994 pairwise allele analysis indicated that G-C haplotypes also significantly correlated with higher level of ESR as well as CRP. These findings provide a better understanding of STIM1 genetic contribution to the pathogenesis of AS.
Ankylosing spondylitis (AS) is a chronic inflammation of the sacroiliac joints, spine and peripheral joints. The development of ankylosing spondylitis is still unclear. Genetics factors such as human leukocyte antigen HLA-B27 and ERAP1 have been widely reported to associate to AS susceptibility. In this study, we enrolled 361 AS patients and selected four tagging single nucleotides polymorphisms (tSNPs) at STIM1 gene. The correlation between STIM1 genetic polymorphisms and AS activity index (BASDAI, BASFI, BAS-G) as well as laboratory parameters of inflammation (erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP)) were tested. Our results indicated that HLA-B27 positive AS patients who are carrying the minor allele homozygous G/G genotype of SNP rs3750996 significantly associated with a higher level of ESR in serum. Furthermore, rs3750996/rs3750994 pairwise allele analysis indicated that G-C haplotypes also significantly correlated with higher level of ESR as well as CRP. These findings provide a better understanding of STIM1 genetic contribution to the pathogenesis of AS.
Audience Academic
Author Wong, Ruey-Hong
Wu, Shyh-Jong
Huang, Chun-Huang
Jan, Ming-Shiou
Wei, James Cheng-Chung
Chang, Wei-Chiao
Hsu, Yu-Wen
Hung, Kuo-Sheng
Juan, Yung-Shun
AuthorAffiliation 8 Department of Urology, Kaohsiung municipal Hsiao-Kang Hospital and College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
5 Department of Public Health, Chung Shan Medical University, Taichung, Taiwan
2 Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan
7 Department of Medical Laboratory Science and Biotechnology, College of Health Sciences, Kaohsiung Medical University, Kaohsiung, Taiwan
6 Institute of Microbiology and Immunology, Chung Shan Medical University, Taichung, Taiwan
1 Division of Allergy, Immunology and Rheumatology, Department of Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan
Institut Jacques Monod, France
3 Department of Neurosurgery, Center of Excellence for Clinical Trial and Research, Graduate Institute of Injury Prevention and Control, Taipei Medical University, Wan Fang Medical Center, Taipei, Taiwan
4 Department of Clinical Pharmacy, School of Pharmacy, Taipei Medical University, Taipei, Taiwan
9 Department of Pharmacy
AuthorAffiliation_xml – name: 4 Department of Clinical Pharmacy, School of Pharmacy, Taipei Medical University, Taipei, Taiwan
– name: 6 Institute of Microbiology and Immunology, Chung Shan Medical University, Taichung, Taiwan
– name: Institut Jacques Monod, France
– name: 7 Department of Medical Laboratory Science and Biotechnology, College of Health Sciences, Kaohsiung Medical University, Kaohsiung, Taiwan
– name: 3 Department of Neurosurgery, Center of Excellence for Clinical Trial and Research, Graduate Institute of Injury Prevention and Control, Taipei Medical University, Wan Fang Medical Center, Taipei, Taiwan
– name: 2 Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan
– name: 8 Department of Urology, Kaohsiung municipal Hsiao-Kang Hospital and College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
– name: 1 Division of Allergy, Immunology and Rheumatology, Department of Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan
– name: 9 Department of Pharmacy, Taipei Medical University-Wanfang Hospital, Taipei, Taiwan
– name: 5 Department of Public Health, Chung Shan Medical University, Taichung, Taiwan
Author_xml – sequence: 1
  givenname: James Cheng-Chung
  surname: Wei
  fullname: Wei, James Cheng-Chung
– sequence: 2
  givenname: Kuo-Sheng
  surname: Hung
  fullname: Hung, Kuo-Sheng
– sequence: 3
  givenname: Yu-Wen
  surname: Hsu
  fullname: Hsu, Yu-Wen
– sequence: 4
  givenname: Ruey-Hong
  surname: Wong
  fullname: Wong, Ruey-Hong
– sequence: 5
  givenname: Chun-Huang
  surname: Huang
  fullname: Huang, Chun-Huang
– sequence: 6
  givenname: Ming-Shiou
  surname: Jan
  fullname: Jan, Ming-Shiou
– sequence: 7
  givenname: Shyh-Jong
  surname: Wu
  fullname: Wu, Shyh-Jong
– sequence: 8
  givenname: Yung-Shun
  surname: Juan
  fullname: Juan, Yung-Shun
– sequence: 9
  givenname: Wei-Chiao
  surname: Chang
  fullname: Chang, Wei-Chiao
BackLink https://www.ncbi.nlm.nih.gov/pubmed/23272049$$D View this record in MEDLINE/PubMed
BookMark eNqNk9tu1DAQhiNURGnhDRBYQkJwsUti58gF0lKVdqWiVl3g1nKcycbFsRfbKeyD8X7MHlp1qwqhRIoz_v7fMyPPQbRnrIEoepHE44QVyfsrOzgj9HiB4XEcp1VelY-ip0nF6CinMdu7s96PDry_iuOMlXn-JNqnjBYUJU-jPydgIChJLqxe9tYtOuV7T2xLZsHZXmgyNQGckEFZQ75YDXLQQBIy8d5KJQI05JcKHQkdkGO3DJ2zchmAzKBRPZgg1sJLBIkwDTkaXcLK7BrIhbMBlCH4np5NRp9ogUl4td6bmB9LjT9mTmZYYLPUGPfkAt3Q0z-LHrdCe3i-_R5G3z4ffz06HZ2dn0yPJmcjmVc0jFIQRVlDXhdQpVTQJIkTqFksy4rWNJWiLas6TxuWFZCvEVbQhqK2zhqQgh1Grza-C0yGbzvueYLtSyiL8wyJ6YZorLjiC6d64ZbcCsXXAevmXDjsrwbeJhTKQsoaBEtr2ZSsjTNaCVmAiHGNXh-3pw11D43ESp3QO6a7O0Z1fG6vOcsozctVMm-3Bs7-HMAH3isvQWthwA6YNy3w5mRFVSD6-h76cHVbai6wAGVai-fKlSmfpEURlyyLK6TGD1D4NNAridezVRjfEbzbESAT4HeYi8F7Pp1d_j97_n2XfXOH7UDo0Hmrh9UV9Lvgy7udvm3xzVwgkG4A6az3DtpbJIn5avxu2sVX48e344eyD_dkUm0mADui9L_FfwFYpzkh
CitedBy_id crossref_primary_10_1016_j_jecm_2013_02_004
crossref_primary_10_1097_MD_0000000000025243
crossref_primary_10_1111_1756_185X_12619
crossref_primary_10_1073_pnas_1511285112
crossref_primary_10_1080_14397595_2019_1639916
crossref_primary_10_1371_journal_pone_0104525
crossref_primary_10_1016_j_gene_2017_12_050
crossref_primary_10_3390_jpm10040287
crossref_primary_10_1007_s00296_013_2894_x
crossref_primary_10_1097_MD_0000000000019234
crossref_primary_10_1111_1756_185X_14876
crossref_primary_10_1139_bcb_2017_0267
crossref_primary_10_3390_ijms18010083
crossref_primary_10_1038_hr_2017_84
crossref_primary_10_1371_journal_pone_0130982
crossref_primary_10_1007_s12013_014_0082_6
crossref_primary_10_1155_2013_171573
Cites_doi 10.1093/carcin/bgs021
10.1093/rheumatology/33.10.927
10.1016/S0140-6736(99)03219-5
10.1016/S0022-1759(01)00414-8
10.1056/NEJMoa0900082
10.1016/S1521-6942(02)90243-3
10.1016/j.immuni.2011.03.016
10.1007/s10067-007-0573-6
10.1074/jbc.M705002200
10.1371/journal.pone.0020426
10.1002/art.24838
10.1111/j.1749-6632.2011.06240.x
10.1016/j.ceca.2011.04.004
10.1016/S0140-6736(73)91360-3
10.1002/art.1780270401
10.1016/S0140-6736(07)60635-7
10.1111/j.1744-313X.2009.00889.x
10.1093/rheumatology/keh193
10.1073/pnas.1103315108
10.1111/j.1365-3083.2009.02265.x
10.4049/jimmunol.1001796
10.1152/physrev.00057.2003
10.1016/j.cellsig.2011.08.017
10.1007/s00198-003-1501-5
10.1083/jcb.200502019
10.1097/01.SMJ.0000066946.56322.3C
10.1111/j.1399-0039.2009.01411.x
10.1016/j.juro.2010.12.094
10.1096/fj.06-6016fje
ContentType Journal Article
Copyright COPYRIGHT 2012 Public Library of Science
2012 Wei et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
2012 Wei et al 2012 Wei et al
Copyright_xml – notice: COPYRIGHT 2012 Public Library of Science
– notice: 2012 Wei et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
– notice: 2012 Wei et al 2012 Wei et al
DBID AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
IOV
ISR
3V.
7QG
7QL
7QO
7RV
7SN
7SS
7T5
7TG
7TM
7U9
7X2
7X7
7XB
88E
8AO
8C1
8FD
8FE
8FG
8FH
8FI
8FJ
8FK
ABJCF
ABUWG
AEUYN
AFKRA
ARAPS
ATCPS
AZQEC
BBNVY
BENPR
BGLVJ
BHPHI
C1K
CCPQU
D1I
DWQXO
FR3
FYUFA
GHDGH
GNUQQ
H94
HCIFZ
K9.
KB.
KB0
KL.
L6V
LK8
M0K
M0S
M1P
M7N
M7P
M7S
NAPCQ
P5Z
P62
P64
PATMY
PDBOC
PHGZM
PHGZT
PIMPY
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQQKQ
PQUKI
PTHSS
PYCSY
RC3
7X8
5PM
DOA
DOI 10.1371/journal.pone.0049698
DatabaseName CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
In Context: Opposing Viewpoints
Gale In Context: Science
ProQuest Central (Corporate)
Animal Behavior Abstracts
Bacteriology Abstracts (Microbiology B)
Biotechnology Research Abstracts
Nursing & Allied Health Database
Ecology Abstracts
Entomology Abstracts (Full archive)
Immunology Abstracts
Meteorological & Geoastrophysical Abstracts
Nucleic Acids Abstracts
Virology and AIDS Abstracts
Agricultural Science Collection
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
ProQuest Pharma Collection
Public Health Database
Technology Research Database
ProQuest SciTech Collection
ProQuest Technology Collection
ProQuest Natural Science Collection
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
Materials Science & Engineering Collection
ProQuest Central (Alumni)
ProQuest One Sustainability
ProQuest Central UK/Ireland
Advanced Technologies & Aerospace Collection
Agricultural & Environmental Science Collection
ProQuest Central Essentials
Biological Science Collection
ProQuest Central
Technology Collection
Natural Science Collection
Environmental Sciences and Pollution Management
ProQuest One
ProQuest Materials Science Collection
ProQuest Central Korea
Engineering Research Database
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
AIDS and Cancer Research Abstracts
SciTech Premium Collection
ProQuest Health & Medical Complete (Alumni)
Materials Science Database
Nursing & Allied Health Database (Alumni Edition)
Meteorological & Geoastrophysical Abstracts - Academic
ProQuest Engineering Collection
Biological Sciences
Agricultural Science Database
ProQuest Health & Medical Collection
Medical Database
Algology Mycology and Protozoology Abstracts (Microbiology C)
Biological Science Database
Engineering Database
Nursing & Allied Health Premium
ProQuest advanced technologies & aerospace journals
ProQuest Advanced Technologies & Aerospace Collection
Biotechnology and BioEngineering Abstracts
Environmental Science Database
Materials Science Collection
ProQuest Central Premium
ProQuest One Academic
Publicly Available Content Database
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Applied & Life Sciences
ProQuest One Academic
ProQuest One Academic UKI Edition
Engineering collection
Environmental Science Collection
Genetics Abstracts
MEDLINE - Academic
PubMed Central (Full Participant titles)
DOAJ Directory of Open Access Journals
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
Agricultural Science Database
Publicly Available Content Database
ProQuest Central Student
ProQuest Advanced Technologies & Aerospace Collection
ProQuest Central Essentials
Nucleic Acids Abstracts
SciTech Premium Collection
Environmental Sciences and Pollution Management
ProQuest One Applied & Life Sciences
ProQuest One Sustainability
Health Research Premium Collection
Meteorological & Geoastrophysical Abstracts
Natural Science Collection
Health & Medical Research Collection
Biological Science Collection
ProQuest Central (New)
ProQuest Medical Library (Alumni)
Engineering Collection
Advanced Technologies & Aerospace Collection
Engineering Database
Virology and AIDS Abstracts
ProQuest Biological Science Collection
ProQuest One Academic Eastern Edition
Agricultural Science Collection
ProQuest Hospital Collection
ProQuest Technology Collection
Health Research Premium Collection (Alumni)
Biological Science Database
Ecology Abstracts
ProQuest Hospital Collection (Alumni)
Biotechnology and BioEngineering Abstracts
Environmental Science Collection
Entomology Abstracts
Nursing & Allied Health Premium
ProQuest Health & Medical Complete
ProQuest One Academic UKI Edition
Environmental Science Database
ProQuest Nursing & Allied Health Source (Alumni)
Engineering Research Database
ProQuest One Academic
Meteorological & Geoastrophysical Abstracts - Academic
ProQuest One Academic (New)
Technology Collection
Technology Research Database
ProQuest One Academic Middle East (New)
Materials Science Collection
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest One Health & Nursing
ProQuest Natural Science Collection
ProQuest Pharma Collection
ProQuest Central
ProQuest Health & Medical Research Collection
Genetics Abstracts
ProQuest Engineering Collection
Biotechnology Research Abstracts
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
Bacteriology Abstracts (Microbiology B)
Algology Mycology and Protozoology Abstracts (Microbiology C)
Agricultural & Environmental Science Collection
AIDS and Cancer Research Abstracts
Materials Science Database
ProQuest Materials Science Collection
ProQuest Public Health
ProQuest Nursing & Allied Health Source
ProQuest SciTech Collection
Advanced Technologies & Aerospace Database
ProQuest Medical Library
Animal Behavior Abstracts
Materials Science & Engineering Collection
Immunology Abstracts
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList Agricultural Science Database



MEDLINE - Academic


MEDLINE
Database_xml – sequence: 1
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 2
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 3
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 4
  dbid: 8FG
  name: ProQuest Technology Collection
  url: https://search.proquest.com/technologycollection1
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Sciences (General)
Medicine
Biology
DocumentTitleAlternate SNPs of STIM1 in Ankylosing Spondylitis Patients
EISSN 1932-6203
ExternalDocumentID 1327123065
oai_doaj_org_article_f12e87ccbea34bcd83f0529ac7ea03f0
PMC3522685
2945352071
A477083509
23272049
10_1371_journal_pone_0049698
Genre Journal Article
GeographicLocations Taiwan
GeographicLocations_xml – name: Taiwan
GroupedDBID ---
123
29O
2WC
53G
5VS
7RV
7X2
7X7
7XC
88E
8AO
8C1
8CJ
8FE
8FG
8FH
8FI
8FJ
A8Z
AAFWJ
AAUCC
AAWOE
AAYXX
ABDBF
ABIVO
ABJCF
ABUWG
ACGFO
ACIHN
ACIWK
ACPRK
ACUHS
ADBBV
ADRAZ
AEAQA
AENEX
AEUYN
AFKRA
AFPKN
AFRAH
AHMBA
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AOIJS
APEBS
ARAPS
ATCPS
BAWUL
BBNVY
BCNDV
BENPR
BGLVJ
BHPHI
BKEYQ
BPHCQ
BVXVI
BWKFM
CCPQU
CITATION
CS3
D1I
D1J
D1K
DIK
DU5
E3Z
EAP
EAS
EBD
EMOBN
ESX
EX3
F5P
FPL
FYUFA
GROUPED_DOAJ
GX1
HCIFZ
HH5
HMCUK
HYE
IAO
IEA
IGS
IHR
IHW
INH
INR
IOV
IPNFZ
IPY
ISE
ISR
ITC
K6-
KB.
KQ8
L6V
LK5
LK8
M0K
M1P
M48
M7P
M7R
M7S
M~E
NAPCQ
O5R
O5S
OK1
OVT
P2P
P62
PATMY
PDBOC
PHGZM
PHGZT
PIMPY
PQQKQ
PROAC
PSQYO
PTHSS
PYCSY
RIG
RNS
RPM
SV3
TR2
UKHRP
WOQ
WOW
~02
~KM
BBORY
CGR
CUY
CVF
ECM
EIF
NPM
PV9
RZL
PMFND
3V.
7QG
7QL
7QO
7SN
7SS
7T5
7TG
7TM
7U9
7XB
8FD
8FK
AZQEC
C1K
DWQXO
FR3
GNUQQ
H94
K9.
KL.
M7N
P64
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQUKI
RC3
7X8
5PM
PUEGO
AAPBV
ABPTK
N95
ID FETCH-LOGICAL-c692t-4ea78be6b7e942a21101eb30c892b24caf89b64d357e6e942a372d2692b5deca3
IEDL.DBID M48
ISSN 1932-6203
IngestDate Sun May 07 16:28:21 EDT 2023
Wed Aug 27 00:50:56 EDT 2025
Thu Aug 21 17:58:47 EDT 2025
Fri Jul 11 15:15:45 EDT 2025
Fri Jul 25 12:12:11 EDT 2025
Tue Jun 17 21:28:37 EDT 2025
Tue Jun 10 20:40:47 EDT 2025
Fri Jun 27 04:40:45 EDT 2025
Fri Jun 27 04:54:33 EDT 2025
Thu May 22 21:10:37 EDT 2025
Thu Apr 03 07:09:52 EDT 2025
Tue Jul 01 03:23:38 EDT 2025
Thu Apr 24 23:08:01 EDT 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 12
Language English
License This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
Creative Commons Attribution License
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c692t-4ea78be6b7e942a21101eb30c892b24caf89b64d357e6e942a372d2692b5deca3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
Competing Interests: The authors have declared that no competing interests exist.
Conceived and designed the experiments: JW KH YH HW WC. Performed the experiments: YH CH MJ SW. Analyzed the data: YH CH YJ KH HW WC. Contributed reagents/materials/analysis tools: WC YJ JW KH. Wrote the paper: WC HW JW YH.
OpenAccessLink http://journals.scholarsportal.info/openUrl.xqy?doi=10.1371/journal.pone.0049698
PMID 23272049
PQID 1327123065
PQPubID 1436336
PageCount e49698
ParticipantIDs plos_journals_1327123065
doaj_primary_oai_doaj_org_article_f12e87ccbea34bcd83f0529ac7ea03f0
pubmedcentral_primary_oai_pubmedcentral_nih_gov_3522685
proquest_miscellaneous_1273715797
proquest_journals_1327123065
gale_infotracmisc_A477083509
gale_infotracacademiconefile_A477083509
gale_incontextgauss_ISR_A477083509
gale_incontextgauss_IOV_A477083509
gale_healthsolutions_A477083509
pubmed_primary_23272049
crossref_primary_10_1371_journal_pone_0049698
crossref_citationtrail_10_1371_journal_pone_0049698
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2012-12-14
PublicationDateYYYYMMDD 2012-12-14
PublicationDate_xml – month: 12
  year: 2012
  text: 2012-12-14
  day: 14
PublicationDecade 2010
PublicationPlace United States
PublicationPlace_xml – name: United States
– name: San Francisco
– name: San Francisco, USA
PublicationTitle PloS one
PublicationTitleAlternate PLoS One
PublicationYear 2012
Publisher Public Library of Science
Public Library of Science (PLoS)
Publisher_xml – name: Public Library of Science
– name: Public Library of Science (PLoS)
References E Safrany (ref6) 2009; 70
K Yildirim (ref23) 2004; 97
S Feske (ref29) 2011; 1238
AB Parekh (ref11) 2005; 85
WY Lee (ref8) 2010; 75
MK de Vries (ref24) 2009; 61
MA Khan (ref4) 2002; 16
JC Wei (ref9) 2011; 6
D van der Heijde (ref21) 1997; 24
J Gratacos (ref20) 1994; 33
WC Huang (ref15) 2011; 50
S van der Linden (ref17) 1984; 27
M Matsumoto (ref31) 2011; 34
J Ruof (ref22) 1999; 26
J Roos (ref12) 2005; 169
YF Chen (ref14) 2011; 108
JY Wang (ref16) 2012; 24
C Picard (ref30) 2009; 360
YH Chou (ref10) 2011; 185
CT Chou (ref19) 2001; 255
WC Chang (ref28) 2006; 20
J Braun (ref1) 2007; 369
CA McCarl (ref26) 2010; 185
JC Wei (ref7) 2004; 43
ZS Guo (ref5) 2010; 37
A Calin (ref2) 1999; 354
BM Obermayer-Pietsch (ref25) 2003; 14
WC Chang (ref27) 2008; 283
DA Brewerton (ref3) 1973; 1
S Fedida-Metula (ref13) 2012; 33
JC Wei (ref18) 2007; 26
14530911 - Osteoporos Int. 2003 Dec;14(12):995-1000
22129055 - Ann N Y Acad Sci. 2011 Nov;1238:74-90
21674042 - PLoS One. 2011;6(6):e20426
10229429 - J Rheumatol. 1999 Apr;26(4):966-70
20956344 - J Immunol. 2010 Nov 15;185(10):5845-58
22287561 - Carcinogenesis. 2012 Apr;33(4):740-50
17448825 - Lancet. 2007 Apr 21;369(9570):1379-90
11470282 - J Immunol Methods. 2001 Sep 1;255(1-2):15-22
15113995 - Rheumatology (Oxford). 2004 Jul;43(7):839-42
6231933 - Arthritis Rheum. 1984 Apr;27(4):361-8
10568571 - Lancet. 1999 Nov 13;354(9191):1687-90
17023391 - FASEB J. 2006 Nov;20(13):2381-3
7921752 - Br J Rheumatol. 1994 Oct;33(10):927-31
21876174 - Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15225-30
19420366 - N Engl J Med. 2009 May 7;360(19):1971-80
21605904 - Cell Calcium. 2011 Jul;50(1):27-35
20030788 - Tissue Antigens. 2010 Feb;75(2):119-26
15788710 - Physiol Rev. 2005 Apr;85(2):757-810
21420116 - J Urol. 2011 May;185(5):1742-6
21530328 - Immunity. 2011 May 27;34(5):703-14
4123836 - Lancet. 1973 Apr 28;1(7809):904-7
18156181 - J Biol Chem. 2008 Feb 22;283(8):4622-31
9375888 - J Rheumatol. 1997 Nov;24(11):2225-9
19877087 - Arthritis Rheum. 2009 Nov 15;61(11):1484-90
17286214 - Clin Rheumatol. 2007 Oct;26(10):1685-91
19522770 - Scand J Immunol. 2009 Jul;70(1):68-74
21924350 - Cell Signal. 2012 Jan;24(1):162-9
15866891 - J Cell Biol. 2005 May 9;169(3):435-45
12406434 - Best Pract Res Clin Rheumatol. 2002 Sep;16(4):675-90
19930406 - Int J Immunogenet. 2010 Feb;37(1):33-7
15108827 - South Med J. 2004 Apr;97(4):350-3
References_xml – volume: 33
  start-page: 740
  year: 2012
  ident: ref13
  article-title: Lipid rafts couple store-operated Ca2+ entry to constitutive activation of PKB/Akt in a Ca2+/calmodulin-, Src- and PP2A-mediated pathway and promote melanoma tumor growth
  publication-title: Carcinogenesis
  doi: 10.1093/carcin/bgs021
– volume: 33
  start-page: 927
  year: 1994
  ident: ref20
  article-title: Serum cytokines (IL-6, TNF-alpha, IL-1 beta and IFN-gamma) in ankylosing spondylitis: a close correlation between serum IL-6 and disease activity and severity
  publication-title: Br J Rheumatol
  doi: 10.1093/rheumatology/33.10.927
– volume: 354
  start-page: 1687
  year: 1999
  ident: ref2
  article-title: Impact of sex on inheritance of ankylosing spondylitis: a cohort study
  publication-title: Lancet
  doi: 10.1016/S0140-6736(99)03219-5
– volume: 255
  start-page: 15
  year: 2001
  ident: ref19
  article-title: The detection of the HLA-B27 antigen by immunomagnetic separation and enzyme-linked immunosorbent assay-comparison with a flow cytometric procedure
  publication-title: J Immunol Methods
  doi: 10.1016/S0022-1759(01)00414-8
– volume: 360
  start-page: 1971
  year: 2009
  ident: ref30
  article-title: STIM1 mutation associated with a syndrome of immunodeficiency and autoimmunity
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa0900082
– volume: 16
  start-page: 675
  year: 2002
  ident: ref4
  article-title: Genetic aspects of ankylosing spondylitis
  publication-title: Best Pract Res Clin Rheumatol
  doi: 10.1016/S1521-6942(02)90243-3
– volume: 26
  start-page: 966
  year: 1999
  ident: ref22
  article-title: Validity aspects of erythrocyte sedimentation rate and C-reactive protein in ankylosing spondylitis: a literature review
  publication-title: J Rheumatol
– volume: 34
  start-page: 703
  year: 2011
  ident: ref31
  article-title: The calcium sensors STIM1 and STIM2 control B cell regulatory function through interleukin-10 production
  publication-title: Immunity
  doi: 10.1016/j.immuni.2011.03.016
– volume: 26
  start-page: 1685
  year: 2007
  ident: ref18
  article-title: Evaluation of internal consistency and re-test reliability of Bath ankylosing spondylitis indices in a large cohort of adult and juvenile spondylitis patients in Taiwan
  publication-title: Clin Rheumatol
  doi: 10.1007/s10067-007-0573-6
– volume: 283
  start-page: 4622
  year: 2008
  ident: ref27
  article-title: Local Ca2+ influx through Ca2+ release-activated Ca2+ (CRAC) channels stimulates production of an intracellular messenger and an intercellular pro-inflammatory signal
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M705002200
– volume: 6
  start-page: e20426
  year: 2011
  ident: ref9
  article-title: Association of ORAI1 haplotypes with the risk of HLA-B27 positive ankylosing spondylitis
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0020426
– volume: 61
  start-page: 1484
  year: 2009
  ident: ref24
  article-title: Erythrocyte sedimentation rate, C-reactive protein level, and serum amyloid a protein for patient selection and monitoring of anti-tumor necrosis factor treatment in ankylosing spondylitis
  publication-title: Arthritis Rheum
  doi: 10.1002/art.24838
– volume: 1238
  start-page: 74
  year: 2011
  ident: ref29
  article-title: Immunodeficiency due to defects in store-operated calcium entry
  publication-title: Ann N Y Acad Sci
  doi: 10.1111/j.1749-6632.2011.06240.x
– volume: 50
  start-page: 27
  year: 2011
  ident: ref15
  article-title: Histamine regulates cyclooxygenase 2 gene activation through Orai1-mediated NFkappaB activation in lung cancer cells
  publication-title: Cell Calcium
  doi: 10.1016/j.ceca.2011.04.004
– volume: 1
  start-page: 904
  year: 1973
  ident: ref3
  article-title: Ankylosing spondylitis and HL-A 27
  publication-title: Lancet
  doi: 10.1016/S0140-6736(73)91360-3
– volume: 27
  start-page: 361
  year: 1984
  ident: ref17
  article-title: Evaluation of diagnostic criteria for ankylosing spondylitis. A proposal for modification of the New York criteria
  publication-title: Arthritis Rheum
  doi: 10.1002/art.1780270401
– volume: 369
  start-page: 1379
  year: 2007
  ident: ref1
  article-title: Ankylosing spondylitis
  publication-title: Lancet
  doi: 10.1016/S0140-6736(07)60635-7
– volume: 37
  start-page: 33
  year: 2010
  ident: ref5
  article-title: Association of IL-1 gene complex members with ankylosing spondylitis in Chinese Han population
  publication-title: Int J Immunogenet
  doi: 10.1111/j.1744-313X.2009.00889.x
– volume: 43
  start-page: 839
  year: 2004
  ident: ref7
  article-title: HLA-B60 and B61 are strongly associated with ankylosing spondylitis in HLA-B27-negative Taiwan Chinese patients
  publication-title: Rheumatology (Oxford)
  doi: 10.1093/rheumatology/keh193
– volume: 108
  start-page: 15225
  year: 2011
  ident: ref14
  article-title: Calcium store sensor stromal-interaction molecule 1-dependent signaling plays an important role in cervical cancer growth, migration, and angiogenesis
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1103315108
– volume: 70
  start-page: 68
  year: 2009
  ident: ref6
  article-title: Variants of the IL23R gene are associated with ankylosing spondylitis but not with Sjogren syndrome in Hungarian population samples
  publication-title: Scand J Immunol
  doi: 10.1111/j.1365-3083.2009.02265.x
– volume: 185
  start-page: 5845
  year: 2010
  ident: ref26
  article-title: Store-operated Ca2+ entry through ORAI1 is critical for T cell-mediated autoimmunity and allograft rejection
  publication-title: J Immunol
  doi: 10.4049/jimmunol.1001796
– volume: 85
  start-page: 757
  year: 2005
  ident: ref11
  article-title: Store-operated calcium channels
  publication-title: Physiol Rev
  doi: 10.1152/physrev.00057.2003
– volume: 24
  start-page: 162
  year: 2012
  ident: ref16
  article-title: Involvement of store-operated calcium signaling in EGF-mediated COX-2 gene activation in cancer cells
  publication-title: Cell Signal
  doi: 10.1016/j.cellsig.2011.08.017
– volume: 24
  start-page: 2225
  year: 1997
  ident: ref21
  article-title: Preliminary core sets for endpoints in ankylosing spondylitis. Assessments in Ankylosing Spondylitis Working Group
  publication-title: J Rheumatol
– volume: 14
  start-page: 995
  year: 2003
  ident: ref25
  article-title: Vitamin D receptor initiation codon polymorphism, bone density and inflammatory activity of patients with ankylosing spondylitis
  publication-title: Osteoporos Int
  doi: 10.1007/s00198-003-1501-5
– volume: 169
  start-page: 435
  year: 2005
  ident: ref12
  article-title: STIM1, an essential and conserved component of store-operated Ca2+ channel function
  publication-title: J Cell Biol
  doi: 10.1083/jcb.200502019
– volume: 97
  start-page: 350
  year: 2004
  ident: ref23
  article-title: Relationship between some acute phase reactants and the Bath Ankylosing Spondylitis Disease Activity Index in patients with ankylosing spondylitis
  publication-title: South Med J
  doi: 10.1097/01.SMJ.0000066946.56322.3C
– volume: 75
  start-page: 119
  year: 2010
  ident: ref8
  article-title: Polymorphisms of cytotoxic T lymphocyte-associated antigen-4 and cytokine genes in Taiwanese patients with ankylosing spondylitis
  publication-title: Tissue Antigens
  doi: 10.1111/j.1399-0039.2009.01411.x
– volume: 185
  start-page: 1742
  year: 2011
  ident: ref10
  article-title: A polymorphism of the ORAI1 gene is associated with the risk and recurrence of calcium nephrolithiasis
  publication-title: J Urol
  doi: 10.1016/j.juro.2010.12.094
– volume: 20
  start-page: 2381
  year: 2006
  ident: ref28
  article-title: Ca2+ influx through CRAC channels activates cytosolic phospholipase A2, leukotriene C4 secretion, and expression of c-fos through ERK-dependent and -independent pathways in mast cells
  publication-title: FASEB J
  doi: 10.1096/fj.06-6016fje
– reference: 4123836 - Lancet. 1973 Apr 28;1(7809):904-7
– reference: 15113995 - Rheumatology (Oxford). 2004 Jul;43(7):839-42
– reference: 12406434 - Best Pract Res Clin Rheumatol. 2002 Sep;16(4):675-90
– reference: 21530328 - Immunity. 2011 May 27;34(5):703-14
– reference: 22287561 - Carcinogenesis. 2012 Apr;33(4):740-50
– reference: 22129055 - Ann N Y Acad Sci. 2011 Nov;1238:74-90
– reference: 10229429 - J Rheumatol. 1999 Apr;26(4):966-70
– reference: 10568571 - Lancet. 1999 Nov 13;354(9191):1687-90
– reference: 19522770 - Scand J Immunol. 2009 Jul;70(1):68-74
– reference: 20956344 - J Immunol. 2010 Nov 15;185(10):5845-58
– reference: 18156181 - J Biol Chem. 2008 Feb 22;283(8):4622-31
– reference: 11470282 - J Immunol Methods. 2001 Sep 1;255(1-2):15-22
– reference: 15108827 - South Med J. 2004 Apr;97(4):350-3
– reference: 15866891 - J Cell Biol. 2005 May 9;169(3):435-45
– reference: 15788710 - Physiol Rev. 2005 Apr;85(2):757-810
– reference: 19877087 - Arthritis Rheum. 2009 Nov 15;61(11):1484-90
– reference: 21876174 - Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15225-30
– reference: 7921752 - Br J Rheumatol. 1994 Oct;33(10):927-31
– reference: 17448825 - Lancet. 2007 Apr 21;369(9570):1379-90
– reference: 21605904 - Cell Calcium. 2011 Jul;50(1):27-35
– reference: 17023391 - FASEB J. 2006 Nov;20(13):2381-3
– reference: 21674042 - PLoS One. 2011;6(6):e20426
– reference: 14530911 - Osteoporos Int. 2003 Dec;14(12):995-1000
– reference: 20030788 - Tissue Antigens. 2010 Feb;75(2):119-26
– reference: 9375888 - J Rheumatol. 1997 Nov;24(11):2225-9
– reference: 19420366 - N Engl J Med. 2009 May 7;360(19):1971-80
– reference: 6231933 - Arthritis Rheum. 1984 Apr;27(4):361-8
– reference: 19930406 - Int J Immunogenet. 2010 Feb;37(1):33-7
– reference: 21924350 - Cell Signal. 2012 Jan;24(1):162-9
– reference: 17286214 - Clin Rheumatol. 2007 Oct;26(10):1685-91
– reference: 21420116 - J Urol. 2011 May;185(5):1742-6
SSID ssj0053866
Score 2.1833403
Snippet Ankylosing spondylitis (AS) is a chronic inflammation of the sacroiliac joints, spine and peripheral joints. The development of ankylosing spondylitis is still...
SourceID plos
doaj
pubmedcentral
proquest
gale
pubmed
crossref
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
Enrichment Source
StartPage e49698
SubjectTerms Adolescent
Adult
Aged
Alleles
Ankylosing spondylitis
Antigens
Arthritis
B cells
Biology
Blood Sedimentation
C-reactive protein
C-Reactive Protein - genetics
Deoxyribonucleic acid
DNA
Enzymes
Erythrocyte sedimentation rate
Erythrocytes
Genes
Genetic aspects
Genetics
Genotype
Haplotypes
Histocompatibility antigen HLA
HLA antigens
HLA-B27 Antigen - biosynthesis
Homozygote
Hospitals
Humans
Immunology
Inflammation
Interleukin-6 - metabolism
Joint diseases
Laboratories
Leukocytes
Medical research
Medical schools
Medicine
Membrane Proteins - genetics
Membrane Proteins - metabolism
Middle Aged
Neoplasm Proteins - genetics
Neoplasm Proteins - metabolism
Nucleotides
Pathogenesis
Patients
Pharmacy
Polymorphism, Genetic
Polymorphism, Single Nucleotide
Proteins
Sequence Analysis, DNA
Severity of Illness Index
Single nucleotide polymorphisms
Single-nucleotide polymorphism
Spine
Spondylitis
Spondylitis, Ankylosing - diagnosis
Spondylitis, Ankylosing - genetics
STIM1 protein
Stromal Interaction Molecule 1
Studies
Tagging
Tumor Necrosis Factor-alpha - metabolism
Tumor necrosis factor-TNF
SummonAdditionalLinks – databaseName: DOAJ Directory of Open Access Journals
  dbid: DOA
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3db9MwELfQnnhBjK8VBhiEBDxka5zEjh-7iakgPiRgaG-R49hQ0SZV3SL1D-P_4852owVNGg-8RfXPaXN3Pt81598R8sIIZmots0QURZ3k0jYJmDJPikwLzYUtrX9j-uEjn57n7y6Ki0utvrAmLNADB8Ed25SZUmhdG5XltW7KzOLLKaWFUWO4Ru8Le94umQo-GFYx5_GgXCbS46iXo2XXmiMMirksBxuR5-vvvfLect65q0LOvysnL21FZ7fJrRhD0kn47fvkhmnvkP24Sh19FamkX98lv_ESUHTZzSHJB5nO3MLRzlK3XnULuAnSRazC4Qa6CK1yDU2pilozDcV_aimEidSstthUQW_XhjrY8xbx2FJLkW6CqrahpwnEoN6DUk8AMWvhC-j0_SQ5YYKGArFfCP25hWeHXZNihW6zxRo8RyPHq7tHzs_efD2dJrFRQ6K5ZOskN0qUteG1MDJnCnPKFJL0sS4lq1mulS1lzfMmK4ThHpIJ1jCYWxeN0Sq7T_ZaUM0BodJCAA0pFi91msMcyZRtrEwt40rJcT4i2U5rlY4s5thMY175V3MCspmghAp1XUVdj0jSz1oGFo9r8CdoED0WObj9B2CZVbTM6jrLHJGnaE5VONDae5JqkguBge9Yjshzj0AejhYLfb6rjXPV20_f_gH05fMA9DKCbAfi0CoeroBnQn6vAfJwgARvogfDB2j8O6k4kBETKeapBczcLYirh5_1w3hTLN5rTbcBDITIIi2EFCPyIKyfXrIQ0GObJPheMVhZA9EPR9rZD0-D7lOHsnj4P3T1iNyESNi3-UnzQ7K3Xm3MY4g21_UT71j-AOW1hLI
  priority: 102
  providerName: Directory of Open Access Journals
– databaseName: ProQuest Technology Collection
  dbid: 8FG
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3db9MwELegSIgXxMbHCgMMQgIesjVfdvyEummlIApVy9DeIsexR0WblKZ96B_G_8ed4xSCJkDqQ1T_nI873_nOPt8R8kLzQGdKhB6P48yLhMk9GMrMi0PFFeMmMXbHdPSRDc-j9xfxhVtwq1xYZaMTraLOS4Vr5MfgNXHf1jl_s_zuYdUo3F11JTSukxs-zDQY0pUM3jaaGGSZMXdcLuT-sePO0bIs9BGaxkwkrenIZu3f6ebOcl5WVxmef8ZP_jYhDe6Q286SpP2a9Xvkmi72yc2R2yvfJ3tObCv6yuWWfn2X_MBL6EDH5Ry8fiDyrFpUtDR0ul6VC7ifXSKsTzvQUV07V1OfNmzUOcWlWwp2Iz1bbbHKgtquNZ3CcxfuHFNBJwCkssjpqTfR0qpUOsaMELOCwm_4oe-dBBxeorKhS7RffNsCGWAapVOgW77FoLyKjuukr9U9cj44-3w69FzlBk8xEay9SEueZJplXIsokOhk-uC191QigiyIlDSJyFiUhzHXzEJCHuQB9M3iXCsZ3iedArh0QKgwYFGDz8US5UfQRwTS5Eb4JmBSil7UJWHDwFS5tOZYXWOe2r06Du5NzY8U2Z46tneJt-u1rNN6_AN_gmNjh8Wk3PaPcnWZOhlPjR_ohCuVaRlGmcqT0OA-qlRcyx5cd8lTHFlpfcJ1p1rSfsQ5WsI90SXPLQITcxQY-XMpN1WVvvv05T9A00kL9NKBTAnkUNKdtoBvwoRfLeRhCwnqRbWaD1AOGqpU6S9BhJ6NbFzd_GzXjDfFaL5ClxvAgM3M_ZgL3iUPalHaURYsfKybBM_lLSFrkb7dUsy-2rzo1pdI4od_f61H5BYYvbaijx8dks56tdGPwbBcZ0-s9vgJioB8Ew
  priority: 102
  providerName: ProQuest
Title Genetic Polymorphisms of Stromal Interaction Molecule 1 Associated with the Erythrocyte Sedimentation Rate and C-Reactive Protein in HLA-B27 Positive Ankylosing Spondylitis Patients
URI https://www.ncbi.nlm.nih.gov/pubmed/23272049
https://www.proquest.com/docview/1327123065
https://www.proquest.com/docview/1273715797
https://pubmed.ncbi.nlm.nih.gov/PMC3522685
https://doaj.org/article/f12e87ccbea34bcd83f0529ac7ea03f0
http://dx.doi.org/10.1371/journal.pone.0049698
Volume 7
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3db9MwELf28cILYnytYxSDkICHTI3z4fgBobXaGIgNNBjaW-Q4zqhokxK3iL7wX_H_cee4EUFF7MWK4rOt3Pnsu_j8O0Keas50pkTg8SjKvFAUuQdTOfaiQHEV8yIp7Inp6Vl8chG-vYwuN8gqZ6tjoFnr2mE-qYt6cvDj2_IVKPxLm7WB-6tGB7Oq1Ado8sYi2STbsDdxzGlwGrbnCqDd9vQSrRYvZoPAXab7Vy-dzcpi-rcr99ZsUpl1Zunf0ZV_bFfHt8hNZ2fSw2Zi7JANXd4mO06TDX3u4KZf3CG_8BGo6KyaLKcV8H1spoZWBTXzuppCJwgpUTcXIOi0SaerqU-lk6zOKf7NpWBKUl0vMfGCWs41NbAvTt3VppIiJAWVZU5HHtipdpWlFiRiXMIA9OTdoTdknDZBZN-R9OsSvh12VopRvPkS4_QMdTiw5i65OD76NDrxXDIHT8WCzb1QS55kOs64FiGT6Hf64MgPVCJYxkIli0RkcZgHEdexJQk4yxm0zaJcKxncI1sliGaXUFGAkQ1uWJwoP4Q2gskiL4RfsFhKMQh7JFhJLVUO6RwTbkxSe3zHweNphJCirFMn6x7x2lazBunjP_RDnBAtLeJ02xdVfZU6tU8Ln-mEK5VpGYSZypOgwKNVqbiWA3jukUc4ndLm0mu72qSHIedoHA9EjzyxFIjVUWIw0JVcGJO-ef_5GkQfzztEzxxRUQE7lHQXMOCbEAOsQ7nfoYQVR3Wqd3Hyr7higEeM--jLRtBypRDrqx-31dgpBviVuloADZjR3I-44D1yv9GflrNg9GMqJRiXdzSrw_puTTn-YqHSrXuRRHvXGPcBuQHGsM3044f7ZGteL_RDMDjnWZ9s8ksOZTLysTx-3Sfbw6OzD-d9-wunb9cYLH8e_QYMvorT
linkProvider Scholars Portal
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtR1db9Mw0BpDAl4QGx8rDGYQCPaQrXE-HD8g1I2Njq1jWje0t-A4zqhok9J0Qv1TvPH_uHOcQtAEvEzKQxSfneTufL6z74OQ55oznSjhOTwIEscXWeoAK4dO4CmuQp5FmTkx7R2G3VP__VlwtkC-17Ew6FZZy0QjqNNC4R75JlhN3DV1zt-MvzpYNQpPV-sSGhVb7OvZNzDZytd7b4G-Lxjb3TnZ7jq2qoCjQsGmjq8ljxIdJlwLn0k0gFywKNsqEixhvpJZJJLQT72A69CAeJylDPomQaqV9GDca-S678FKjpHpu-9qyQ-yIwxteJ7H3U3LDRvjItcbqIqHImosf6ZKwHwtWBwPi_IyRfdPf83fFsDdO-S21Vxpp2K1JbKg82Vyo2fP5pfJkhUTJX1lc1mv3yU_8BY60KNiOBsVQNRBOSppkdH-dFKMYDyzJVlFV9BeVatXU5fWbKNTilvFFPRUujOZYVUHNZtq2of3jmzcVE6PAZDKPKXbzrGWRoTTI8xAMcgpXN2DjrPFOHxEaVylaCf_MgM0wLJN-4C3dIZOgCU9qpLMlvfI6ZXQ9D5ZzIFKK4SKDDR4sPHCSLk-9BFMZmkm3IyFUoq23yJeTcBY2TTqWM1jGJuzQQ7mVEWPGMkeW7K3iDPvNa7SiPwDfgt5Yw6LScDNg2JyHluZEmcu0xFXKtHS8xOVRl6G57ZScS3bcN8ia8hZcRVROxdlccfnHDXvtmiRZwYCE4Hk6Gl0Li_KMt778PE_gPrHDaCXFigrAB1K2ugO-CdMMNaAXG1AgjhTjeYVnAc1Vsr418SHnvXcuLz56bwZB0XvwVwXFwADOjp3Ay54izyoptIcs2BRYJ0meC9vTLIG6pst-eCzycNubJcoePj3z1ojN7snvYP4YO9w_xG5BQq3qSbk-qtkcTq50I9BqZ0mT4wkoeTTVYuun4sNuSM
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtR3LbtQw0CpFqrggWh5dKNQgEHBIu3Eejg8IbbetWvpg1aWot-A4TqnoJstmV2g_jAtfx4zjBIIq4FJpD9F6nMe8PGPPg5DnmjOdKOE5PAgSxxdZ6gArh07gKa5CnkWZOTE9Og73Tv13Z8HZAvlR58JgWGWtE42iTguFe-Sb4DVx1_Q538xsWMRge_ft-KuDHaTwpLVup1GxyIGefwP3rXyzvw20fsHY7s6H_p5jOww4KhRs6vha8ijRYcK18JlEZ8gF77KrIsES5iuZRSIJ_dQLuA4NiMdZymBuEqRaSQ_ue4Pc5B6PUMaifhNeAnokDG2qnsfdTcsZG-Mi1xtolociai2FpmNAsy4sji-L8iqj98_Yzd8Ww9075La1YmmvYrtlsqDzFbJ0ZM_pV8iyVRklfWXrWr--S77jJUygg-JyPiqAwBflqKRFRofTSTGC-5ntySrTgh5VfXs1dWnNQjqluG1MwWalO5M5dnhQ86mmQ3juyOZQ5fQEAKnMU9p3TrQ06pwOsBrFRU7ht3fYc7YYh5coTdgU7eVf5oAGWMLpEPCWzjEgsKSDquBseY-cXgtN75PFHKi0SqjIwJoHfy-MlOvDHMFklmbCzVgopej6HeLVBIyVLamOnT0uY3NOyMG1qugRI9ljS_YOcZpZ46qkyD_gt5A3GlgsCG7-KCbnsdUvceYyHXGlEi09P1Fp5GV4hisV17IL1x2yjpwVV9m1jVqLez7naIV3RYc8MxBYFCRH8TqXs7KM999__A-g4UkL6KUFygpAh5I20wO-CYuNtSDXWpCg2lRreBXloMZKGf9SAjCzlo2rh582w3hTjCTMdTEDGLDXuRtwwTvkQSVKDWbBu8CeTfBc3hKyFurbI_nFZ1OT3fgxUfDw76-1TpZAacWH-8cHj8gtsL1NYyHXXyOL08lMPwb7dpo8MYqEkk_Xrbl-ApLxvSQ
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Genetic+polymorphisms+of+stromal+interaction+molecule+1+associated+with+the+erythrocyte+sedimentation+rate+and+C-reactive+protein+in+HLA-B27+positive+ankylosing+spondylitis+patients&rft.jtitle=PloS+one&rft.au=Wei%2C+James+Cheng-Chung&rft.au=Hung%2C+Kuo-Sheng&rft.au=Hsu%2C+Yu-Wen&rft.au=Wong%2C+Ruey-Hong&rft.date=2012-12-14&rft.issn=1932-6203&rft.eissn=1932-6203&rft.volume=7&rft.issue=12&rft.spage=e49698&rft_id=info:doi/10.1371%2Fjournal.pone.0049698&rft.externalDBID=NO_FULL_TEXT
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1932-6203&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1932-6203&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1932-6203&client=summon