Accurate point-of-care serology tests for COVID-19

• Published in: PloS one Vol. 16; no. 3; p. e0248729
• Main Authors: Schuler, Charles F., Gherasim, Carmen, O’Shea, Kelly, Manthei, David M., Chen, Jesse, Giacherio, Don, Troost, Jonathan P., Baldwin, James L., Baker, James R.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 16.03.2021; Public Library of Science (PLoS)
• Subjects: Adult; Aged; Antibodies; Antibodies, Viral - blood; Biology and Life Sciences; Coronaviruses; COVID-19; COVID-19 - diagnosis; COVID-19 - virology; COVID-19 diagnostic tests; COVID-19 Serological Testing; Data analysis; Diagnosis; Drafting software; Editing; Engineering and Technology; Epidemics; Female; Food allergies; Food hypersensitivity; Funding; Genetic aspects; Humans; Immunoassay; Immunoglobulin G - blood; Immunoglobulin M - blood; Immunology; Infections; Internal medicine; Laboratories; Male; Medical personnel; Medicine; Medicine and Health Sciences; Methodology; Middle Aged; Nanotechnology; Nucleocapsid - immunology; Pandemics; Pathology; Point of care testing; Point-of-Care Systems; Polymerase chain reaction; Reagent Kits, Diagnostic; Research and Analysis Methods; SARS-CoV-2 - immunology; SARS-CoV-2 - isolation & purification; Sensitivity and Specificity; Serodiagnosis; Serology; Severe acute respiratory syndrome; Severe acute respiratory syndrome coronavirus 2; Software; Supervision; United States; Vaccines; Viral diseases; Visualization; Young Adult; United States; Ann Arbor Michigan; United States > US; Michigan

As COVID-19 vaccines become available, screening individuals for prior COVID-19 infection and vaccine response in point-of-care (POC) settings has renewed interest. We prospectively screened at-risk individuals for SARS-CoV-2 spike and nucleocapsid protein antibodies in a POC setting to determine if...