Characterization of Changes in Gene Expression and Biochemical Pathways at Low Levels of Benzene Exposure

• Published in: PloS one Vol. 9; no. 5; p. e91828
• Main Authors: Thomas, Reuben, Hubbard, Alan E., McHale, Cliona M., Zhang, Luoping, Rappaport, Stephen M., Lan, Qing, Rothman, Nathaniel, Vermeulen, Roel, Guyton, Kathryn Z., Jinot, Jennifer, Sonawane, Babasaheb R., Smith, Martyn T.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.05.2014; Public Library of Science (PLoS)
• Subjects: Acute myeloid leukemia; Air Pollutants, Occupational - adverse effects; B cells; Benzene; Benzene - adverse effects; Biology and Life Sciences; Blood Cell Count; Bone marrow; Cancer; Cluster Analysis; Clustering; Comparative analysis; Diabetes; Epidemiology; Exposure; Female; Gene expression; Gene Expression Profiling; Gene Expression Regulation - drug effects; Genes; Hematology; Humans; Hydrocarbons; Leukemia; Leukemia, Myeloid, Acute - blood; Leukemia, Myeloid, Acute - genetics; Leukemia, Myeloid, Acute - metabolism; Leukocytes (mononuclear); Male; Medical research; Medicine and Health Sciences; Metabolic Networks and Pathways - drug effects; Metabolism; Mutation; Myeloid leukemia; Occupational exposure; Occupational Exposure - adverse effects; Peripheral blood mononuclear cells; Phenols; Physical Sciences; Pollutants; Public health; Risk assessment; Rodents; Signal transduction; Studies; Toxicology; United States > US; Maryland; California

Benzene, a ubiquitous environmental pollutant, causes acute myeloid leukemia (AML). Recently, through transcriptome profiling of peripheral blood mononuclear cells (PBMC), we reported dose-dependent effects of benzene exposure on gene expression and biochemical pathways in 83 workers exposed across...