Blockade of Kv1.3 potassium channels inhibits differentiation and granzyme B secretion of human CD8+ T effector memory lymphocytes

• Published in: PloS one Vol. 8; no. 1; p. e54267
• Main Authors: Hu, Lina, Wang, Tongguang, Gocke, Anne R, Nath, Avindra, Zhang, Hao, Margolick, Joseph B, Whartenby, Katharine A, Calabresi, Peter A
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 30.01.2013; Public Library of Science (PLoS)
• Subjects: Antigens; Autoimmune diseases; Binding sites; Biology; CD4 antigen; CD8 antigen; CD8-Positive T-Lymphocytes - cytology; CD8-Positive T-Lymphocytes - drug effects; CD8-Positive T-Lymphocytes - immunology; Cell differentiation; Cell Differentiation - drug effects; Cell Differentiation - genetics; Cell proliferation; Cell Proliferation - drug effects; Cells (biology); Channels; Computer memory; Conversion; Cytotoxicity; Differentiation (biology); Effector cells; Genotype & phenotype; Granzyme B; Granzymes - genetics; Granzymes - immunology; Granzymes - metabolism; Health care; Humans; Immunologic Memory - drug effects; Immunologic Memory - genetics; Immunological memory; Immunology; Kv1.3 Potassium Channel - antagonists & inhibitors; Kv1.3 Potassium Channel - genetics; Kv1.3 Potassium Channel - metabolism; Lymphocyte Activation - immunology; Lymphocytes; Lymphocytes T; Medicine; Memory cells; Multiple sclerosis; Nervous system; Neural stem cells; Neurological disorders; Neurology; Pharmacology; Potassium; Potassium Channel Blockers - pharmacology; Potassium channels; Potassium channels (voltage-gated); Public health; Signal transduction; T cell receptors; T cells; Toxicity; United States > US; Maryland; Baltimore Maryland

Increased expression of the voltage-gated potassium channel Kν1.3 on activated effector memory T cells (T(EM)) is associated with pathology in multiple sclerosis (MS). To date, most studies of Kν1.3 channels in MS have focused on CD4+ T(EM) cells. Much less is known about the functional relevance of...