Effects of theophylline on ADCY5 activation—From cellular studies to improved therapeutic options for ADCY5-related dyskinesia patients

• Published in: PloS one Vol. 18; no. 3; p. e0282593
• Main Authors: Tänzler, Dirk, Kipping, Marc, Lederer, Marcell, Günther, Wiebke F., Arlt, Christian, Hüttelmaier, Stefan, Merkenschlager, Andreas, Sinz, Andrea
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 03.03.2023; Public Library of Science (PLoS)
• Subjects: Adenosine triphosphate; Adenylate cyclase; Amino acids; Biology and Life Sciences; Bronchodilator Agents; Caffeine; Care and treatment; Catalytic activity; Cell lines; Child, Preschool; Comparative analysis; Cyclic adenylic acid; Cyclic AMP; Diuretics; Dyskinesia; Dyskinesias; Enzymes; Health aspects; Humans; Instrument industry; Medical research; Medicine and Health Sciences; Medicine, Experimental; Movement disorders; Mutants; Mutation; Patient outcomes; Phosphodiesterase Inhibitors; Physical Sciences; Psychomotor Agitation; Signs and symptoms; Theophylline; Vasodilator Agents; Germany; United States

We show the effects of the three purine derivatives, caffeine, theophylline, and istradefylline, on cAMP production by adenylyl cyclase 5 (ADCY5)-overexpressing cell lines. A comparison of cAMP levels was performed for ADCY5 wild-type and R418W mutant cells. ADCY5-catalyzed cAMP production was reduc...