Carriage of stx2a Differentiates Clinical and Bovine-Biased Strains of Escherichia coli O157

• Published in: PloS one Vol. 7; no. 12; p. e51572
• Main Authors: Shringi, Smriti, Schmidt, Carrie, Katherine, Kaya, Brayton, Kelly A., Hancock, Dale D., Besser, Thomas E.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 11.12.2012; Public Library of Science (PLoS)
• Subjects: Animals; Bacteriophages - genetics; Bacteriophages - metabolism; Beef cattle; Biology; Bovidae; Cattle; Chromosome rearrangements; Clinical isolates; Cytotoxicity; Disease; E coli; Epidemics; Escherichia coli; Escherichia coli Infections - genetics; Escherichia coli O157 - genetics; Escherichia coli O157 - pathogenicity; Gene mapping; Genes; Genetic aspects; Genomes; Genomics; Genotypes; Humans; Insertion; Mortality; Multiplexing; Pathology; Phages; Shiga toxin; Shiga Toxin - genetics; Shiga Toxin - metabolism; Shiga Toxin 2 - genetics; Shiga Toxin 2 - metabolism; Strains (organisms); Toxins; Veterinary Science; Virulence; Virulence - genetics; Virulence factors; United States > US

Shiga toxin (Stx) are cardinal virulence factors of enterohemorrhagic E. coli O157:H7 (EHEC O157). The gene content and genomic insertion sites of Stx-associated bacteriophages differentiate clinical genotypes of EHEC O157 (CG, typical of clinical isolates) from bovine-biased genotypes (BBG, rarely...