Lack of an Association between CYP11B2 C-344T Gene Polymorphism and Ischemic Stroke: A Meta-Analysis of 7,710 Subjects

• Published in: PloS one Vol. 8; no. 8; p. e68842
• Main Authors: Pi, Yan, Zhang, Li-li, Chang, Kai, Guo, Lu, Liu, Yun, Li, Bing-hu, Cao, Xiao-jie, Liao, Shao-qiong, Gao, Chang-yue, Li, Jing-cheng
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 08.08.2013; Public Library of Science (PLoS)
• Subjects: Adult; Aged; Aldosterone; Aldosterone synthase; Analysis; Binding sites; Biology; Cardiovascular disease; Confidence intervals; Cytochrome P-450; Cytochrome P-450 CYP11B2 - genetics; Epidemiology; Ethnicity; Female; Gene polymorphism; Genes; Genetic aspects; Genetic Association Studies; Genetic polymorphisms; Genetic Predisposition to Disease; Glucocorticoids; Health risks; Heterogeneity; Hospitals; Humans; Hypertension; Ischemia; Male; Medical ethics; Medicine; Meta-analysis; Middle Aged; Minority & ethnic groups; Models, Genetic; Neurology; Polymorphism; Polymorphism, Single Nucleotide; Population; Quality; Regression analysis; Risk analysis; Risk factors; Statistical analysis; Stroke; Stroke - genetics; Studies; Surgery; Systematic review; Thrombosis; China

The association between aldosterone synthase (CYP11B2) C-344T gene polymorphism and ischemic stroke remains controversial and ambiguous. To better explain the association between CYP11B2 polymorphism and ischemic stroke risk, a meta-analysis was performed. Based on comprehensive searches of Medline,...