Lack of an Association between CYP11B2 C-344T Gene Polymorphism and Ischemic Stroke: A Meta-Analysis of 7,710 Subjects

The association between aldosterone synthase (CYP11B2) C-344T gene polymorphism and ischemic stroke remains controversial and ambiguous. To better explain the association between CYP11B2 polymorphism and ischemic stroke risk, a meta-analysis was performed. Based on comprehensive searches of Medline,...

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Published inPloS one Vol. 8; no. 8; p. e68842
Main Authors Pi, Yan, Zhang, Li-li, Chang, Kai, Guo, Lu, Liu, Yun, Li, Bing-hu, Cao, Xiao-jie, Liao, Shao-qiong, Gao, Chang-yue, Li, Jing-cheng
Format Journal Article
LanguageEnglish
Published United States Public Library of Science 08.08.2013
Public Library of Science (PLoS)
Subjects
Adult
Aged
Aldosterone
Aldosterone synthase
Analysis
Binding sites
Biology
Cardiovascular disease
Confidence intervals
Cytochrome P-450
Cytochrome P-450 CYP11B2 - genetics
Epidemiology
Ethnicity
Female
Gene polymorphism
Genes
Genetic aspects
Genetic Association Studies
Genetic polymorphisms
Genetic Predisposition to Disease
Glucocorticoids
Health risks
Heterogeneity
Hospitals
Humans
Hypertension
Ischemia
Male
Medical ethics
Medicine
Meta-analysis
Middle Aged
Minority & ethnic groups
Models, Genetic
Neurology
Polymorphism
Polymorphism, Single Nucleotide
Population
Quality
Regression analysis
Risk analysis
Risk factors
Statistical analysis
Stroke
Stroke - genetics
Studies
Surgery
Systematic review
Thrombosis
China
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Abstract The association between aldosterone synthase (CYP11B2) C-344T gene polymorphism and ischemic stroke remains controversial and ambiguous. To better explain the association between CYP11B2 polymorphism and ischemic stroke risk, a meta-analysis was performed. Based on comprehensive searches of Medline, Embase, Web of Science, CNKI and CBM databases, we identified and abstracted outcome data from all articles to evaluate the association between CYP11B2 polymorphism and ischemic stroke. The pooled odds ratios (ORs) with 95% confidence intervals (CIs) were performed in all genetic models. Fixed or random effects model was separately used depending on the heterogeneity between studies. Publication bias was tested by Begg's funnel plot and Egger's regression test. A total of 12 studies including 3,620 ischemic stroke cases and 4,090 controls were identified. There was no statistical evidence of association between CYP11B2 C-344T polymorphism and ischemic stroke in all genetic models (allelic model: OR = 1.19, 95% CI = 0.95-1.49; additive model: OR = 1.43, 95% CI = 0.91-2.27; dominant model: OR = 1.30, 95% CI = 0.89-1.89; and recessive model: OR = 1.24, 95% CI = 0.96-1.60). On subgroup analysis by ethnicity, similarly results were found in both Asians and non-Asians. For Asians, the combined ORs and 95% CIs were (allelic model: OR = 1.07, 95% CI = 0.87-1.32; additive model: OR = 1.15, 95% CI = 0.77-1.71; dominant model: OR = 1.13, 95% CI = 0.92-1.38; and recessive model: OR = 1.09, 95% CI = 0.84-1.40). For none-Asians, the combined ORs and 95% CIs were (allelic model: OR = 1.58, 95% CI = 0.90-2.76; additive model: OR = 2.37, 95% CI = 0.79-7.05; dominant model: OR = 1.79, 95% CI = 0.77-4.19; and recessive model: OR = 1.80, 95% CI = 0.96-3.36). The present meta-analysis suggested that CYP11B2 C-344T polymorphism was unlikely contribute to ischemic stroke susceptibility.
AbstractList Background The association between aldosterone synthase (CYP11B2) C-344T gene polymorphism and ischemic stroke remains controversial and ambiguous. To better explain the association between CYP11B2 polymorphism and ischemic stroke risk, a meta-analysis was performed. Methods Based on comprehensive searches of Medline, Embase, Web of Science, CNKI and CBM databases, we identified and abstracted outcome data from all articles to evaluate the association between CYP11B2 polymorphism and ischemic stroke. The pooled odds ratios (ORs) with 95% confidence intervals (CIs) were performed in all genetic models. Fixed or random effects model was separately used depending on the heterogeneity between studies. Publication bias was tested by Begg's funnel plot and Egger's regression test. Results A total of 12 studies including 3,620 ischemic stroke cases and 4,090 controls were identified. There was no statistical evidence of association between CYP11B2 C-344T polymorphism and ischemic stroke in all genetic models (allelic model: OR = 1.19, 95% CI = 0.95-1.49; additive model: OR = 1.43, 95% CI = 0.91-2.27; dominant model: OR = 1.30, 95% CI = 0.89-1.89; and recessive model: OR = 1.24, 95% CI = 0.96-1.60). On subgroup analysis by ethnicity, similarly results were found in both Asians and non-Asians. For Asians, the combined ORs and 95% CIs were (allelic model: OR = 1.07, 95% CI = 0.87-1.32; additive model: OR = 1.15, 95% CI = 0.77-1.71; dominant model: OR = 1.13, 95% CI = 0.92-1.38; and recessive model: OR = 1.09, 95% CI = 0.84-1.40). For none-Asians, the combined ORs and 95% CIs were (allelic model: OR = 1.58, 95% CI = 0.90-2.76; additive model: OR = 2.37, 95% CI = 0.79-7.05; dominant model: OR = 1.79, 95% CI = 0.77-4.19; and recessive model: OR = 1.80, 95% CI = 0.96-3.36). Conclusion The present meta-analysis suggested that CYP11B2 C-344T polymorphism was unlikely contribute to ischemic stroke susceptibility.
The association between aldosterone synthase (CYP11B2) C-344T gene polymorphism and ischemic stroke remains controversial and ambiguous. To better explain the association between CYP11B2 polymorphism and ischemic stroke risk, a meta-analysis was performed.BACKGROUNDThe association between aldosterone synthase (CYP11B2) C-344T gene polymorphism and ischemic stroke remains controversial and ambiguous. To better explain the association between CYP11B2 polymorphism and ischemic stroke risk, a meta-analysis was performed.Based on comprehensive searches of Medline, Embase, Web of Science, CNKI and CBM databases, we identified and abstracted outcome data from all articles to evaluate the association between CYP11B2 polymorphism and ischemic stroke. The pooled odds ratios (ORs) with 95% confidence intervals (CIs) were performed in all genetic models. Fixed or random effects model was separately used depending on the heterogeneity between studies. Publication bias was tested by Begg's funnel plot and Egger's regression test.METHODSBased on comprehensive searches of Medline, Embase, Web of Science, CNKI and CBM databases, we identified and abstracted outcome data from all articles to evaluate the association between CYP11B2 polymorphism and ischemic stroke. The pooled odds ratios (ORs) with 95% confidence intervals (CIs) were performed in all genetic models. Fixed or random effects model was separately used depending on the heterogeneity between studies. Publication bias was tested by Begg's funnel plot and Egger's regression test.A total of 12 studies including 3,620 ischemic stroke cases and 4,090 controls were identified. There was no statistical evidence of association between CYP11B2 C-344T polymorphism and ischemic stroke in all genetic models (allelic model: OR = 1.19, 95% CI = 0.95-1.49; additive model: OR = 1.43, 95% CI = 0.91-2.27; dominant model: OR = 1.30, 95% CI = 0.89-1.89; and recessive model: OR = 1.24, 95% CI = 0.96-1.60). On subgroup analysis by ethnicity, similarly results were found in both Asians and non-Asians. For Asians, the combined ORs and 95% CIs were (allelic model: OR = 1.07, 95% CI = 0.87-1.32; additive model: OR = 1.15, 95% CI = 0.77-1.71; dominant model: OR = 1.13, 95% CI = 0.92-1.38; and recessive model: OR = 1.09, 95% CI = 0.84-1.40). For none-Asians, the combined ORs and 95% CIs were (allelic model: OR = 1.58, 95% CI = 0.90-2.76; additive model: OR = 2.37, 95% CI = 0.79-7.05; dominant model: OR = 1.79, 95% CI = 0.77-4.19; and recessive model: OR = 1.80, 95% CI = 0.96-3.36).RESULTSA total of 12 studies including 3,620 ischemic stroke cases and 4,090 controls were identified. There was no statistical evidence of association between CYP11B2 C-344T polymorphism and ischemic stroke in all genetic models (allelic model: OR = 1.19, 95% CI = 0.95-1.49; additive model: OR = 1.43, 95% CI = 0.91-2.27; dominant model: OR = 1.30, 95% CI = 0.89-1.89; and recessive model: OR = 1.24, 95% CI = 0.96-1.60). On subgroup analysis by ethnicity, similarly results were found in both Asians and non-Asians. For Asians, the combined ORs and 95% CIs were (allelic model: OR = 1.07, 95% CI = 0.87-1.32; additive model: OR = 1.15, 95% CI = 0.77-1.71; dominant model: OR = 1.13, 95% CI = 0.92-1.38; and recessive model: OR = 1.09, 95% CI = 0.84-1.40). For none-Asians, the combined ORs and 95% CIs were (allelic model: OR = 1.58, 95% CI = 0.90-2.76; additive model: OR = 2.37, 95% CI = 0.79-7.05; dominant model: OR = 1.79, 95% CI = 0.77-4.19; and recessive model: OR = 1.80, 95% CI = 0.96-3.36).The present meta-analysis suggested that CYP11B2 C-344T polymorphism was unlikely contribute to ischemic stroke susceptibility.CONCLUSIONThe present meta-analysis suggested that CYP11B2 C-344T polymorphism was unlikely contribute to ischemic stroke susceptibility.
The association between aldosterone synthase (CYP11B2) C-344T gene polymorphism and ischemic stroke remains controversial and ambiguous. To better explain the association between CYP11B2 polymorphism and ischemic stroke risk, a meta-analysis was performed. Based on comprehensive searches of Medline, Embase, Web of Science, CNKI and CBM databases, we identified and abstracted outcome data from all articles to evaluate the association between CYP11B2 polymorphism and ischemic stroke. The pooled odds ratios (ORs) with 95% confidence intervals (CIs) were performed in all genetic models. Fixed or random effects model was separately used depending on the heterogeneity between studies. Publication bias was tested by Begg's funnel plot and Egger's regression test. A total of 12 studies including 3,620 ischemic stroke cases and 4,090 controls were identified. There was no statistical evidence of association between CYP11B2 C-344T polymorphism and ischemic stroke in all genetic models (allelic model: OR = 1.19, 95% CI = 0.95-1.49; additive model: OR = 1.43, 95% CI = 0.91-2.27; dominant model: OR = 1.30, 95% CI = 0.89-1.89; and recessive model: OR = 1.24, 95% CI = 0.96-1.60). On subgroup analysis by ethnicity, similarly results were found in both Asians and non-Asians. For Asians, the combined ORs and 95% CIs were (allelic model: OR = 1.07, 95% CI = 0.87-1.32; additive model: OR = 1.15, 95% CI = 0.77-1.71; dominant model: OR = 1.13, 95% CI = 0.92-1.38; and recessive model: OR = 1.09, 95% CI = 0.84-1.40). For none-Asians, the combined ORs and 95% CIs were (allelic model: OR = 1.58, 95% CI = 0.90-2.76; additive model: OR = 2.37, 95% CI = 0.79-7.05; dominant model: OR = 1.79, 95% CI = 0.77-4.19; and recessive model: OR = 1.80, 95% CI = 0.96-3.36). The present meta-analysis suggested that CYP11B2 C-344T polymorphism was unlikely contribute to ischemic stroke susceptibility.
The association between aldosterone synthase (CYP11B2) C-344T gene polymorphism and ischemic stroke remains controversial and ambiguous. To better explain the association between CYP11B2 polymorphism and ischemic stroke risk, a meta-analysis was performed. Based on comprehensive searches of Medline, Embase, Web of Science, CNKI and CBM databases, we identified and abstracted outcome data from all articles to evaluate the association between CYP11B2 polymorphism and ischemic stroke. The pooled odds ratios (ORs) with 95% confidence intervals (CIs) were performed in all genetic models. Fixed or random effects model was separately used depending on the heterogeneity between studies. Publication bias was tested by Begg's funnel plot and Egger's regression test. A total of 12 studies including 3,620 ischemic stroke cases and 4,090 controls were identified. There was no statistical evidence of association between CYP11B2 C-344T polymorphism and ischemic stroke in all genetic models (allelic model: OR = 1.19, 95% CI = 0.95-1.49; additive model: OR = 1.43, 95% CI = 0.91-2.27; dominant model: OR = 1.30, 95% CI = 0.89-1.89; and recessive model: OR = 1.24, 95% CI = 0.96-1.60). On subgroup analysis by ethnicity, similarly results were found in both Asians and non-Asians. For Asians, the combined ORs and 95% CIs were (allelic model: OR = 1.07, 95% CI = 0.87-1.32; additive model: OR = 1.15, 95% CI = 0.77-1.71; dominant model: OR = 1.13, 95% CI = 0.92-1.38; and recessive model: OR = 1.09, 95% CI = 0.84-1.40). For none-Asians, the combined ORs and 95% CIs were (allelic model: OR = 1.58, 95% CI = 0.90-2.76; additive model: OR = 2.37, 95% CI = 0.79-7.05; dominant model: OR = 1.79, 95% CI = 0.77-4.19; and recessive model: OR = 1.80, 95% CI = 0.96-3.36). The present meta-analysis suggested that CYP11B2 C-344T polymorphism was unlikely contribute to ischemic stroke susceptibility.
Background The association between aldosterone synthase (CYP11B2) C-344T gene polymorphism and ischemic stroke remains controversial and ambiguous. To better explain the association between CYP11B2 polymorphism and ischemic stroke risk, a meta-analysis was performed. Methods Based on comprehensive searches of Medline, Embase, Web of Science, CNKI and CBM databases, we identified and abstracted outcome data from all articles to evaluate the association between CYP11B2 polymorphism and ischemic stroke. The pooled odds ratios (ORs) with 95% confidence intervals (CIs) were performed in all genetic models. Fixed or random effects model was separately used depending on the heterogeneity between studies. Publication bias was tested by Begg's funnel plot and Egger's regression test. Results A total of 12 studies including 3,620 ischemic stroke cases and 4,090 controls were identified. There was no statistical evidence of association between CYP11B2 C-344T polymorphism and ischemic stroke in all genetic models (allelic model: OR = 1.19, 95% CI = 0.95–1.49; additive model: OR = 1.43, 95% CI = 0.91–2.27; dominant model: OR = 1.30, 95% CI = 0.89–1.89; and recessive model: OR = 1.24, 95% CI = 0.96–1.60). On subgroup analysis by ethnicity, similarly results were found in both Asians and non-Asians. For Asians, the combined ORs and 95% CIs were (allelic model: OR = 1.07, 95% CI = 0.87–1.32; additive model: OR = 1.15, 95% CI = 0.77–1.71; dominant model: OR = 1.13, 95% CI = 0.92–1.38; and recessive model: OR = 1.09, 95% CI = 0.84–1.40). For none-Asians, the combined ORs and 95% CIs were (allelic model: OR = 1.58, 95% CI = 0.90–2.76; additive model: OR = 2.37, 95% CI = 0.79–7.05; dominant model: OR = 1.79, 95% CI = 0.77–4.19; and recessive model: OR = 1.80, 95% CI = 0.96–3.36). Conclusion The present meta-analysis suggested that CYP11B2 C-344T polymorphism was unlikely contribute to ischemic stroke susceptibility.
Audience Academic
Author Pi, Yan
Cao, Xiao-jie
Zhang, Li-li
Li, Jing-cheng
Gao, Chang-yue
Li, Bing-hu
Guo, Lu
Liu, Yun
Chang, Kai
Liao, Shao-qiong
AuthorAffiliation 2 Department of Clinical Laboratory Medicine, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, China
1 Department of Neurology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, China
The Scripps Research Institute, United States of America
AuthorAffiliation_xml – name: 2 Department of Clinical Laboratory Medicine, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, China
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/23950878$$D View this record in MEDLINE/PubMed
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CitedBy_id crossref_primary_10_4103_jpbs_jpbs_313_23
crossref_primary_10_1016_j_gene_2014_11_015
crossref_primary_10_12659_MSM_896904
crossref_primary_10_3390_genes14061184
crossref_primary_10_37489_2588_0527_2020_1_19_25
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Copyright_xml – notice: COPYRIGHT 2013 Public Library of Science
– notice: 2013 Pi et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
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DocumentTitleAlternate CYP11B2 Gene Polymorphism and Ischemic Stroke
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Conceived and designed the experiments: JCL YP LLZ. Performed the experiments: YP LLZ KC JCL. Analyzed the data: YP KC. Contributed reagents/materials/analysis tools: YP LG YL BHL XJC SQL CYG. Wrote the paper: YP LLZ JCL.
Competing Interests: The authors have declared that no competing interests exist.
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Snippet The association between aldosterone synthase (CYP11B2) C-344T gene polymorphism and ischemic stroke remains controversial and ambiguous. To better explain the...
Background The association between aldosterone synthase (CYP11B2) C-344T gene polymorphism and ischemic stroke remains controversial and ambiguous. To better...
BACKGROUND: The association between aldosterone synthase (CYP11B2) C-344T gene polymorphism and ischemic stroke remains controversial and ambiguous. To better...
Background The association between aldosterone synthase (CYP11B2) C-344T gene polymorphism and ischemic stroke remains controversial and ambiguous. To better...
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SubjectTerms Adult
Aged
Aldosterone
Aldosterone synthase
Analysis
Binding sites
Biology
Cardiovascular disease
Confidence intervals
Cytochrome P-450
Cytochrome P-450 CYP11B2 - genetics
Epidemiology
Ethnicity
Female
Gene polymorphism
Genes
Genetic aspects
Genetic Association Studies
Genetic polymorphisms
Genetic Predisposition to Disease
Glucocorticoids
Health risks
Heterogeneity
Hospitals
Humans
Hypertension
Ischemia
Male
Medical ethics
Medicine
Meta-analysis
Middle Aged
Minority & ethnic groups
Models, Genetic
Neurology
Polymorphism
Polymorphism, Single Nucleotide
Population
Quality
Regression analysis
Risk analysis
Risk factors
Statistical analysis
Stroke
Stroke - genetics
Studies
Surgery
Systematic review
Thrombosis
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Title Lack of an Association between CYP11B2 C-344T Gene Polymorphism and Ischemic Stroke: A Meta-Analysis of 7,710 Subjects
URI https://www.ncbi.nlm.nih.gov/pubmed/23950878
https://www.proquest.com/docview/1430254647
https://www.proquest.com/docview/1426019503
https://pubmed.ncbi.nlm.nih.gov/PMC3738569
https://doaj.org/article/120fb58f7a444cc3951a50acb0ee3130
http://dx.doi.org/10.1371/journal.pone.0068842
Volume 8
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