The intestinal virome in children with cystic fibrosis differs from healthy controls

• Published in: PloS one Vol. 15; no. 5; p. e0233557
• Main Authors: Coffey, Michael J, Low, Ivan, Stelzer-Braid, Sacha, Wemheuer, Bernd, Garg, Millie, Thomas, Torsten, Jaffe, Adam, Rawlinson, William D, Ooi, Chee Y
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 22.05.2020; Public Library of Science (PLoS)
• Subjects: Age; Annotations; Antibiotics; Biochemical cycles; Biochemistry; Biodiversity; Biology and Life Sciences; Capsid protein; Children; Children & youth; Childrens health; Complications and side effects; Computer and Information Sciences; Cystic fibrosis; Deoxyribonucleic acid; Development and progression; Digestive system; DNA; DNA sequencing; DNA viruses; Dysbacteriosis; Dysbiosis; Ecology and Environmental Sciences; Enteroviruses; Environmental science; Enzymes; F protein; Faecalibacterium; Fibrosis; Genes; Health aspects; Hospitals; Hydrolases; Inflammation; Intestine; Laboratories; Lysins; Medicine and Health Sciences; Microbiota; Microbiota (Symbiotic organisms); Mutation; Novels; Nutrition research; Pancreas; Pediatric research; People and Places; Peptidoglycans; Phages; Physiological aspects; Proteins; Pyruvate kinase; Pyruvic acid; Relative abundance; Ribonucleic acid; Risk factors; RNA; Single-stranded DNA; Species diversity; Taxonomy; Therapeutic applications; Viral proteins; Virology; Viruses; Womens health; Australia; United Kingdom > UK; New South Wales Australia; Wales

Intestinal bacterial dysbiosis is evident in children with cystic fibrosis (CF) and intestinal viruses may be contributory, given their influence on bacterial species diversity and biochemical cycles. We performed a prospective, case-control study on children with CF and age and gender matched healt...