Parkinson's Disease in Saudi Patients: A Genetic Study

• Published in: PloS one Vol. 10; no. 8; p. e0135950
• Main Authors: Al-Mubarak, Bashayer R, Bohlega, Saeed A, Alkhairallah, Thamer S, Magrashi, Amna I, AlTurki, Maha I, Khalil, Dania S, AlAbdulaziz, Basma S, Abou Al-Shaar, Hussam, Mustafa, Abeer E, Alyemni, Eman A, Alsaffar, Bashayer A, Tahir, Asma I, Al Tassan, Nada A
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 14.08.2015; Public Library of Science (PLoS)
• Subjects: Adolescent; Adult; Analysis; Basal ganglia; Brain diseases; Brain research; Case-Control Studies; Central nervous system diseases; Child; Child, Preschool; Dopamine receptors; Dosage; Etiology; Family medical history; Female; Gene dosage; Gene expression; Gene sequencing; Genes; Genetics; Genomes; Humans; Infant; LRRK2 protein; Male; Medical research; Mesencephalon; Middle Aged; Molecular chains; Molecular modelling; Movement disorders; Mutation; Neurodegenerative diseases; Neurology; Neurosciences; Oxidative stress; PARK7 protein; Parkin protein; Parkinson Disease - genetics; Parkinson's disease; Patients; Populations; Proteins; PTEN-induced putative kinase; Saudi Arabia; Screening; Saudi Arabia; United States > US; Riyadh Saudi Arabia

Parkinson's disease (PD) is one of the major causes of parkinsonism syndrome. Its characteristic motor symptoms are attributable to dopaminergic neurons loss in the midbrain. Genetic advances have highlighted underlying molecular mechanisms and provided clues to potential therapies. However, mo...