Genetic association analysis of ATP binding cassette protein family reveals a novel association of ABCB1 genetic variants with epilepsy risk, but not with drug-resistance

• Published in: PloS one Vol. 9; no. 2; p. e89253
• Main Authors: Balan, Shabeesh, Bharathan, Sumitha Prameela, Vellichiramal, Neetha Nanoth, Sathyan, Sanish, Joseph, Vijai, Radhakrishnan, Kurupath, Banerjee, Moinak
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 21.02.2014; Public Library of Science (PLoS)
• Subjects: Adolescent; Adult; Alleles; Anticonvulsants; Association analysis; ATP Binding Cassette Transporter, Subfamily B - genetics; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters - genetics; Biology; Biotechnology; Blood-brain barrier; Brain research; Convulsions & seizures; Development and progression; Drug resistance; Drug Resistance - genetics; Drug therapy; Efflux; Epilepsy; Epilepsy - drug therapy; Epilepsy - genetics; Etiology; Female; Gene Frequency; Genetic Association Studies; Genetic diversity; Genetic Predisposition to Disease; Genetic variance; Genetic Variation; Genetics; Genotype; Haplotypes; Hippocampus; Humans; India; Laboratories; Male; Medicine; Meta-analysis; Microbial drug resistance; Multidrug resistance; Neoplasm Proteins - genetics; Population studies; Protein binding; Proteins; Schizophrenia; Sclerosis; Seizures; Seizures (Medicine); Splicing; Studies; Temporal lobe; Young Adult; New York; United States > US; India

Epilepsy constitutes a heterogeneous group of disorders that is characterized by recurrent unprovoked seizures due to widely different etiologies. Multidrug resistance remains a major issue in clinical epileptology, where one third of patients with epilepsy continue to have seizures. Role of efflux...