Epstein–Barr virus-induced gene 3 commits human mesenchymal stem cells to differentiate into chondrocytes via endoplasmic reticulum stress sensor

• Published in: PloS one Vol. 17; no. 12; p. e0279584
• Main Authors: Zhang, Tong, Yamagata, Kaoru, Iwata, Shigeru, Sonomoto, Koshiro, Trimova, Gulzhan, Nguyen, Anh Phuong, Hao, He, Shan, Yu, Nguyen, Mai-Phuong, Nakayamada, Shingo, Tanaka, Yoshiya
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 22.12.2022; Public Library of Science (PLoS)
• Subjects: Accumulation; Analysis; Antibodies; Arthritis; Biology and Life Sciences; Bone marrow; Cartilage; Cell cycle; Cell differentiation; Cell Differentiation - genetics; Chondrocytes; Chondrocytes - cytology; Chondrogenesis; Chondrogenesis - genetics; Control; Cytokines; Differentiation; EBI3 protein; Endoplasmic reticulum; Endoplasmic Reticulum Stress - genetics; Endoribonucleases - genetics; Endoribonucleases - metabolism; Epstein-Barr virus; Health aspects; Humans; Identification and classification; IL-1β; Inositol; Inositols; Interleukin 27; Interleukins; Interleukins - genetics; Interleukins - physiology; Kinases; Medicine and Health Sciences; Mesenchymal stem cells; Mesenchymal Stem Cells - cytology; Minor Histocompatibility Antigens - genetics; Minor Histocompatibility Antigens - physiology; Phenylbutyric acid; Prevention; Protein Serine-Threonine Kinases - genetics; Protein Serine-Threonine Kinases - metabolism; Proteins; Research and Analysis Methods; Rheumatoid arthritis; Risk factors; Sensors; Stem cells; Stress; Stress (Physiology); Tumor necrosis factor-α; Viruses; Japan; United States > US; Chicago Illinois

Mesenchymal stem cells (MSC) can differentiate into chondrocytes. Epstein–Barr virus-induced gene 3 (EBI3) is differentially expressed during chondrogenic differentiation and can be produced by MSC. EBI3 is also a subunit of interleukin (IL)-27 and IL-35, and it accumulates in the endoplasmic reticu...