Pronounced metabolic changes in adaptation to biofilm growth by Streptococcus pneumoniae

• Published in: PloS one Vol. 9; no. 9; p. e107015
• Main Authors: Allan, Raymond N, Skipp, Paul, Jefferies, Johanna, Clarke, Stuart C, Faust, Saul N, Hall-Stoodley, Luanne, Webb, Jeremy
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 04.09.2014; Public Library of Science (PLoS)
• Subjects: Adaptation; Adaptation, Physiological - genetics; Arginine; Bacterial Adhesion - genetics; Bacterial Proteins - genetics; Bacterial Proteins - metabolism; Biofilms; Biofilms - growth & development; Biology and Life Sciences; Biomedical research; Carbohydrate metabolism; Carbohydrates; Colonization; Comparative analysis; Ear diseases; Environmental conditions; Gene Expression Profiling; Gene Expression Regulation, Bacterial; Genotype; Glycolysis; Growth; Health aspects; Hospitals; Life sciences; Medicine; Metabolic Networks and Pathways - genetics; Metabolic pathways; Metabolism; Molecular Sequence Annotation; Morbidity; Phenotype; Plankton - genetics; Plankton - metabolism; Pneumonia; Protein expression; Proteins; Proteomics; Public health; Pyruvic acid; Research and Analysis Methods; Streptococcus infections; Streptococcus pneumoniae; Streptococcus pneumoniae - genetics; Streptococcus pneumoniae - metabolism; Streptococcus pneumoniae - pathogenicity; Tagging; Transcription; Vaccine development; Vaccines; Virulence; United Kingdom > UK; United States > US; Ohio

Streptococcus pneumoniae accounts for a significant global burden of morbidity and mortality and biofilm development is increasingly recognised as important for colonization and infection. Analysis of protein expression patterns during biofilm development may therefore provide valuable insights to t...