Airway microbiome composition correlates with lung function and arterial stiffness in an age-dependent manner

• Published in: PloS one Vol. 14; no. 11; p. e0225636
• Main Authors: Lee, Shuen Yee, Mac Aogáin, Micheál, Fam, Kai Deng, Chia, Kar Ling, Binte Mohamed Ali, Nur A’tikah, Yap, Margaret M. C., Yap, Eric P. H., Chotirmall, Sanjay H., Lim, Chin Leong
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 26.11.2019; Public Library of Science (PLoS)
• Subjects: Abundance; Adult; Adults; Age; Age Factors; Aged; Aging; Asthma; Biodiversity; Biology and Life Sciences; Chronic illnesses; Chronic obstructive pulmonary disease; Composition; Correlation; Cystic fibrosis; Elderly people; Family; Firmicutes; Firmicutes - genetics; Firmicutes - isolation & purification; Gene sequencing; Genes; Geriatrics; Haemophilus - genetics; Haemophilus - isolation & purification; Healthy Volunteers; Hormone replacement therapy; Humans; Inflammation; Laboratories; Leptotrichia - genetics; Leptotrichia - isolation & purification; Lung - physiology; Lung diseases; Lungs; Medicine; Medicine and Health Sciences; Microbiomes; Microbiota; Microorganisms; Middle Aged; Mortality; Older people; Pathogenesis; Pathogens; People and Places; Phenotypes; Physical Sciences; Proteobacteria; Pulse Wave Analysis; Relative abundance; Respiratory function; Respiratory Function Tests; Respiratory tract; Risk factors; RNA; RNA, Ribosomal, 16S - genetics; RNA, Ribosomal, 16S - metabolism; rRNA 16S; Sputum; Sputum - microbiology; Stiffness; Vascular Stiffness - physiology; Wave velocity; Young Adult; Singapore

To investigate age-associated changes in airway microbiome composition and their relationships with lung function and arterial stiffness among genetically matched young and elderly pairs. Twenty-four genetically linked family pairs comprised of younger (≤40 years) and older (≥60 years) healthy parti...