APOBEC3G Variants and Protection against HIV-1 Infection in Burkina Faso

• Published in: PloS one Vol. 11; no. 1; p. e0146386
• Main Authors: Compaore, Tegwinde Rebeca, Soubeiga, Serge Theophile, Ouattara, Abdoul Karim, Obiri-Yeboah, Dorcas, Tchelougou, Damehan, Maiga, Mamoudou, Assih, Maleki, Bisseye, Cyrille, Bakouan, Didier, Compaore, Issaka Pierre, Dembele, Augustine, Martinson, Jeremy, Simpore, Jacques
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 07.01.2016; Public Library of Science (PLoS)
• Subjects: Acquired immune deficiency syndrome; Adolescent; Adult; AIDS; Alleles; Analysis; APOBEC-3G Deaminase; Burkina Faso; Care and treatment; Case-Control Studies; Child; Child, Preschool; Cytidine Deaminase - genetics; Deoxyribonucleic acid; Diagnosis; Disease Progression; Disease Resistance - genetics; DNA; Female; Gene Expression; Gene Frequency; Genetic diversity; Genetic variance; Genomes; Genotypes; Genotyping; Haplotypes; Health risks; HIV; HIV infections; HIV Infections - diagnosis; HIV Infections - genetics; HIV Infections - immunology; HIV Infections - pathology; HIV Infections - virology; HIV-1 - physiology; Human immunodeficiency virus; Humans; Infant; Infant, Newborn; Infections; Infectious diseases; Laboratories; Linkage Disequilibrium; Male; Middle Aged; Minority & ethnic groups; Models, Genetic; Odds Ratio; Phylogeny; Polymorphism, Single Nucleotide; Protein Isoforms - genetics; Proteins; Risk; Risk factors; Sexually transmitted diseases; Single nucleotide polymorphisms; Single-nucleotide polymorphism; Statistical analysis; STD; Studies; Viral infections; Virology; Burkina Faso; United States > US

Studies on host factors, particularly the APOBEC3G gene, have previously found an association with AIDS progression in some populations and against some HIV-1 strains but not others. Our study had two main objectives: firstly, to screen a population from Burkina Faso for three variants of APOBEC3G p...