Increased p66Shc in the Inner Ear of D-Galactose-Induced Aging Mice with Accumulation of Mitochondrial DNA 3873-bp Deletion: p66Shc and mtDNA Damage in the Inner Ear during Aging

• Published in: PloS one Vol. 7; no. 11; p. e50483
• Main Authors: Wu, Lisa, Sun, Yu, Hu, Yu-Juan, Yang, Yang, Yao, Ling-Li, Zhou, Xing-Xing, Wang, Hao, Zhang, Rui, Huang, Xiang, Kong, Wei-Jia
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 27.11.2012; Public Library of Science (PLoS)
• Subjects: Accumulation; Aging; Aging (artificial); Aging - drug effects; Animals; Biology; Chemistry; Clonal deletion; Cochlea; Cytoplasm; D-Galactose; Damage accumulation; Deoxyribonucleic acid; DNA; DNA damage; DNA Damage - drug effects; DNA, Mitochondrial - genetics; DNA, Mitochondrial - metabolism; Ear, Inner - metabolism; Galactose; Galactose - pharmacology; Gene deletion; Impact damage; Inner ear; Kinases; Male; Metabolism; Mice; Mitochondrial DNA; mRNA; Otolaryngology; Oxidation; Oxidative stress; Oxidative Stress - drug effects; RNA; Rodents; Serine; Shc Signaling Adaptor Proteins - genetics; Shc Signaling Adaptor Proteins - metabolism; Src Homology 2 Domain-Containing, Transforming Protein 1; Stria vascularis

Aging has been associated with mitochondrial DNA damage. P66Shc is an age-related adaptor protein that has a substantial impact on mitochondrial metabolism through regulation of the cellular response to oxidative stress. Our study aimed to establish a D-galactose (D-gal)-induced inner ear aging mous...