Increased p66Shc in the Inner Ear of D-Galactose-Induced Aging Mice with Accumulation of Mitochondrial DNA 3873-bp Deletion: p66Shc and mtDNA Damage in the Inner Ear during Aging - Wu, Lisa; Sun, Yu; Hu, Yu-Juan; Yang, Yang; Yao, Ling-Li; Zhou, Xing-Xing; Wang, Hao; Zhang, Rui; Huang, Xiang; Kong, Wei-Jia (PloS one, 2012)
Keywords: Accumulation; Aging; Aging (artificial); Aging - drug effects; Animals; Biology; Chemistry; Clonal deletion; Cochlea; Cytoplasm; D-Galactose; Damage accumulation; Deoxyribonucleic acid; DNA; DNA damage; DNA Damage - drug effects; DNA, Mitochondrial - genetics; DNA, Mitochondrial - metabolism; Ear, Inner - metabolism; Galactose; Galactose - pharmacology; Gene deletion; Impact damage; Inner ear; Kinases; Male; Metabolism; Mice; Mitochondrial DNA; mRNA; Otolaryngology; Oxidation; Oxidative stress; Oxidative Stress - drug effects; RNA; Rodents; Serine; Shc Signaling Adaptor Proteins - genetics; Shc Signaling Adaptor Proteins - metabolism; Src Homology 2 Domain-Containing, Transforming Protein 1; Stria vascularis