Abnormalities of Frontal-Parietal Resting-State Functional Connectivity Are Related to Disease Activity in Patients with Systemic Lupus Erythematosus

• Published in: PloS one Vol. 8; no. 9; p. e74530
• Main Authors: Hou, Jingming, Lin, Yun, Zhang, Wei, Song, Lingheng, Wu, Wenjing, Wang, Jian, Zhou, Daiquan, Zou, Qinghua, Fang, Yongfei, He, Mei, Li, Haitao
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 12.09.2013; Public Library of Science (PLoS)
• Subjects: Abnormalities; Activation; Adult; Anti-DNA antibodies; Autoimmune diseases; Bioindicators; Biomarkers; Care and treatment; Case-Control Studies; Cerebrum; Chronic conditions; Cognition; Cognitive ability; Cognitive disorders; Connectivity; Connectome; Correlation; Correlation analysis; Frontal Lobe - physiopathology; Functional magnetic resonance imaging; Headache; Hospitals; Humans; Information processing; Localization; Lupus; Lupus Erythematosus, Systemic - physiopathology; Magnetic resonance; Magnetic Resonance Imaging; Medical imaging; Medical research; Memory; Mental depression; Mental disorders; Natural language processing; Neural networks; Neuroimaging; Neurology; Neuropsychological Tests; NMR; Nuclear magnetic resonance; Parietal Lobe - physiopathology; Patients; Rheumatology; Schizophrenia; Studies; Syncope; Systemic lupus erythematosus; Visual perception; China

Cerebral involvement is common in patients with systemic Lupus erythematosus (SLE) and is characterized by multiple clinical presentations, including cognitive disorders, headaches, and syncope. Several neuroimaging studies have demonstrated cerebral dysfunction during different tasks among SLE pati...