Relationship between Immune Parameters and Organ Involvement in Children with Henoch-Schonlein Purpura

• Published in: PloS one Vol. 9; no. 12; p. e115261
• Main Authors: Pan, Yan-xiang, Ye, Qing, Shao, Wen-xia, Shang, Shi-qiang, Mao, Jian-hua, Zhang, Ting, Shen, Hong-qiang, Zhao, Ning
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 16.12.2014; Public Library of Science (PLoS)
• Subjects: Antigens; B cells; Biology and Life Sciences; Blood; Blood Cell Count; Blood cells; C-Reactive Protein - metabolism; Child; Children; Complement C3 - metabolism; Complement C4 - metabolism; Connective tissue diseases; Connective tissues; Cytokines; Cytokines - blood; Digestive tract; Erythrocytes; Flow cytometry; Gastrointestinal tract; Heat shock proteins; Helper cells; Hospitals; Humans; Hypersensitivity; Immune response; Immunoglobulin A; Immunoglobulin A - urine; Immunoglobulin E; Immunoglobulin E - blood; Immunoglobulins; Immunoglobulins - immunology; Kidneys; Laboratories; Leukocytes; Lymphocytes; Lymphocytes T; Medicine; Medicine and Health Sciences; Membrane permeability; Nephrology; Pathogenesis; Patients; Permeability; Prospective Studies; Proteins; Proteinuria; Purpura; Purpura, Schoenlein-Henoch - immunology; Purpura, Schoenlein-Henoch - physiopathology; Rodents; Schonlein-Henoch purpura; Statistics, Nonparametric; T-Lymphocytes, Helper-Inducer - immunology; Tumor necrosis factor-TNF; Urinalysis; Urine

Henoch-Schonlein purpura (HSP) is the most common type of connective tissue diseases which increasingly occurs in children in recent years and its pathogenesis remains unclear. In order to explore the immune parameters and underlying pathogenesis mechanism of children with HSP, the study involved 12...