Espresso Coffee Consumption and Risk of Coronary Heart Disease in a Large Italian Cohort

The relationship between coffee consumption and coronary heart disease (CHD) has been investigated in several studies with discrepant results. We examined the association between Italian-style (espresso and mocha) coffee consumption and CHD risk. We investigated 12,800 men and 30,449 women without h...

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Published inPloS one Vol. 10; no. 5; p. e0126550
Main Authors Grioni, Sara, Agnoli, Claudia, Sieri, Sabina, Pala, Valeria, Ricceri, Fulvio, Masala, Giovanna, Saieva, Calogero, Panico, Salvatore, Mattiello, Amalia, Chiodini, Paolo, Tumino, Rosario, Frasca, Graziella, Iacoviello, Licia, de Curtis, Amalia, Vineis, Paolo, Krogh, Vittorio
Format Journal Article
LanguageEnglish
Published United States Public Library of Science 06.05.2015
Public Library of Science (PLoS)
Subjects
Adult
Aged
Caffeine
Cancer
Cardiovascular disease
Cardiovascular diseases
Cholesterol
Coffee
Coffee (Beverage)
Coffee - adverse effects
Cohort Studies
Consumption
Coronary artery disease
Coronary Disease - chemically induced
Coronary Disease - epidemiology
Coronary heart disease
Cups
Diet
Disease prevention
Drinking
Epidemiology
Female
Health aspects
Health care
Health risk assessment
Health risks
Heart
Heart attacks
Heart diseases
High density lipoprotein
Homocysteine
Humans
Italy - epidemiology
Laboratories
Life Style
Lipids
Lipids - blood
Lipoproteins (high density)
Lipoproteins (low density)
Low density lipoprotein
Male
Medical research
Mens health
Middle Aged
Nutrition
Prospective Studies
Public health
Risk
Risk factors
Studies
Surveys and Questionnaires
Triglycerides
Variance analysis
Womens health
Italy
Online AccessGet full text

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Abstract The relationship between coffee consumption and coronary heart disease (CHD) has been investigated in several studies with discrepant results. We examined the association between Italian-style (espresso and mocha) coffee consumption and CHD risk. We investigated 12,800 men and 30,449 women without history of cardiovascular disease recruited to the EPICOR prospective cohort study. Coffee consumption was assessed at baseline. In a random sub-cohort of 1472 subjects, plasma triglycerides, and total, LDL and HDL cholesterol were determined to investigate the effect of coffee consumption on plasma lipids. After a mean follow up of 10.9 years, 804 cases of CHD (500 acute events, 56 fatal events and 248 revascularizations, all first events) were identified. Multivariable adjusted hazard ratios for CHD were: 1.18 (95% CI 0.87-1.60) for drinking 1-2 cups/day, 1.37 (95% CI 1.03-1.82) for >2-4 cups/day and 1.52 (95% CI 1.11-2.07) for over 4 cups/day (P trend <0.001) compared to reference (<1 cup/day). Plasma triglycerides, and total, LDL and HDL cholesterol did not vary significantly (ANOVA) with coffee consumption. Consumption of over 2 cups/day of Italian-style coffee is associated with increased CHD risk, but coffee consumption was not associated with plasma lipid changes, so the adverse effect of consumption appears unrelated to lipid profile.
AbstractList Background The relationship between coffee consumption and coronary heart disease (CHD) has been investigated in several studies with discrepant results. We examined the association between Italian-style (espresso and mocha) coffee consumption and CHD risk. Methods We investigated 12,800 men and 30,449 women without history of cardiovascular disease recruited to the EPICOR prospective cohort study. Coffee consumption was assessed at baseline. In a random sub-cohort of 1472 subjects, plasma triglycerides, and total, LDL and HDL cholesterol were determined to investigate the effect of coffee consumption on plasma lipids. Results After a mean follow up of 10.9 years, 804 cases of CHD (500 acute events, 56 fatal events and 248 revascularizations, all first events) were identified. Multivariable adjusted hazard ratios for CHD were: 1.18 (95% CI 0.87–1.60) for drinking 1–2 cups/day, 1.37 (95% CI 1.03–1.82) for >2–4 cups/day and 1.52 (95% CI 1.11–2.07) for over 4 cups/day (P trend <0.001) compared to reference (<1 cup/day). Plasma triglycerides, and total, LDL and HDL cholesterol did not vary significantly (ANOVA) with coffee consumption. Conclusion Consumption of over 2 cups/day of Italian-style coffee is associated with increased CHD risk, but coffee consumption was not associated with plasma lipid changes, so the adverse effect of consumption appears unrelated to lipid profile.
Background The relationship between coffee consumption and coronary heart disease (CHD) has been investigated in several studies with discrepant results. We examined the association between Italian-style (espresso and mocha) coffee consumption and CHD risk. Methods We investigated 12,800 men and 30,449 women without history of cardiovascular disease recruited to the EPICOR prospective cohort study. Coffee consumption was assessed at baseline. In a random sub-cohort of 1472 subjects, plasma triglycerides, and total, LDL and HDL cholesterol were determined to investigate the effect of coffee consumption on plasma lipids. Results After a mean follow up of 10.9 years, 804 cases of CHD (500 acute events, 56 fatal events and 248 revascularizations, all first events) were identified. Multivariable adjusted hazard ratios for CHD were: 1.18 (95% CI 0.87-1.60) for drinking 1-2 cups/day, 1.37 (95% CI 1.03-1.82) for >2-4 cups/day and 1.52 (95% CI 1.11-2.07) for over 4 cups/day (P trend <0.001) compared to reference (<1 cup/day). Plasma triglycerides, and total, LDL and HDL cholesterol did not vary significantly (ANOVA) with coffee consumption. Conclusion Consumption of over 2 cups/day of Italian-style coffee is associated with increased CHD risk, but coffee consumption was not associated with plasma lipid changes, so the adverse effect of consumption appears unrelated to lipid profile.
The relationship between coffee consumption and coronary heart disease (CHD) has been investigated in several studies with discrepant results. We examined the association between Italian-style (espresso and mocha) coffee consumption and CHD risk.BACKGROUNDThe relationship between coffee consumption and coronary heart disease (CHD) has been investigated in several studies with discrepant results. We examined the association between Italian-style (espresso and mocha) coffee consumption and CHD risk.We investigated 12,800 men and 30,449 women without history of cardiovascular disease recruited to the EPICOR prospective cohort study. Coffee consumption was assessed at baseline. In a random sub-cohort of 1472 subjects, plasma triglycerides, and total, LDL and HDL cholesterol were determined to investigate the effect of coffee consumption on plasma lipids.METHODSWe investigated 12,800 men and 30,449 women without history of cardiovascular disease recruited to the EPICOR prospective cohort study. Coffee consumption was assessed at baseline. In a random sub-cohort of 1472 subjects, plasma triglycerides, and total, LDL and HDL cholesterol were determined to investigate the effect of coffee consumption on plasma lipids.After a mean follow up of 10.9 years, 804 cases of CHD (500 acute events, 56 fatal events and 248 revascularizations, all first events) were identified. Multivariable adjusted hazard ratios for CHD were: 1.18 (95% CI 0.87-1.60) for drinking 1-2 cups/day, 1.37 (95% CI 1.03-1.82) for >2-4 cups/day and 1.52 (95% CI 1.11-2.07) for over 4 cups/day (P trend <0.001) compared to reference (<1 cup/day). Plasma triglycerides, and total, LDL and HDL cholesterol did not vary significantly (ANOVA) with coffee consumption.RESULTSAfter a mean follow up of 10.9 years, 804 cases of CHD (500 acute events, 56 fatal events and 248 revascularizations, all first events) were identified. Multivariable adjusted hazard ratios for CHD were: 1.18 (95% CI 0.87-1.60) for drinking 1-2 cups/day, 1.37 (95% CI 1.03-1.82) for >2-4 cups/day and 1.52 (95% CI 1.11-2.07) for over 4 cups/day (P trend <0.001) compared to reference (<1 cup/day). Plasma triglycerides, and total, LDL and HDL cholesterol did not vary significantly (ANOVA) with coffee consumption.Consumption of over 2 cups/day of Italian-style coffee is associated with increased CHD risk, but coffee consumption was not associated with plasma lipid changes, so the adverse effect of consumption appears unrelated to lipid profile.CONCLUSIONConsumption of over 2 cups/day of Italian-style coffee is associated with increased CHD risk, but coffee consumption was not associated with plasma lipid changes, so the adverse effect of consumption appears unrelated to lipid profile.
The relationship between coffee consumption and coronary heart disease (CHD) has been investigated in several studies with discrepant results. We examined the association between Italian-style (espresso and mocha) coffee consumption and CHD risk. We investigated 12,800 men and 30,449 women without history of cardiovascular disease recruited to the EPICOR prospective cohort study. Coffee consumption was assessed at baseline. In a random sub-cohort of 1472 subjects, plasma triglycerides, and total, LDL and HDL cholesterol were determined to investigate the effect of coffee consumption on plasma lipids. After a mean follow up of 10.9 years, 804 cases of CHD (500 acute events, 56 fatal events and 248 revascularizations, all first events) were identified. Multivariable adjusted hazard ratios for CHD were: 1.18 (95% CI 0.87-1.60) for drinking 1-2 cups/day, 1.37 (95% CI 1.03-1.82) for >2-4 cups/day and 1.52 (95% CI 1.11-2.07) for over 4 cups/day (P trend <0.001) compared to reference (<1 cup/day). Plasma triglycerides, and total, LDL and HDL cholesterol did not vary significantly (ANOVA) with coffee consumption. Consumption of over 2 cups/day of Italian-style coffee is associated with increased CHD risk, but coffee consumption was not associated with plasma lipid changes, so the adverse effect of consumption appears unrelated to lipid profile.
The relationship between coffee consumption and coronary heart disease (CHD) has been investigated in several studies with discrepant results. We examined the association between Italian-style (espresso and mocha) coffee consumption and CHD risk. We investigated 12,800 men and 30,449 women without history of cardiovascular disease recruited to the EPICOR prospective cohort study. Coffee consumption was assessed at baseline. In a random sub-cohort of 1472 subjects, plasma triglycerides, and total, LDL and HDL cholesterol were determined to investigate the effect of coffee consumption on plasma lipids. After a mean follow up of 10.9 years, 804 cases of CHD (500 acute events, 56 fatal events and 248 revascularizations, all first events) were identified. Multivariable adjusted hazard ratios for CHD were: 1.18 (95% CI 0.87-1.60) for drinking 1-2 cups/day, 1.37 (95% CI 1.03-1.82) for >2-4 cups/day and 1.52 (95% CI 1.11-2.07) for over 4 cups/day (P trend <0.001) compared to reference (<1 cup/day). Plasma triglycerides, and total, LDL and HDL cholesterol did not vary significantly (ANOVA) with coffee consumption. Consumption of over 2 cups/day of Italian-style coffee is associated with increased CHD risk, but coffee consumption was not associated with plasma lipid changes, so the adverse effect of consumption appears unrelated to lipid profile.
Audience Academic
Author Vineis, Paolo
Agnoli, Claudia
Chiodini, Paolo
Ricceri, Fulvio
Tumino, Rosario
Iacoviello, Licia
Grioni, Sara
de Curtis, Amalia
Mattiello, Amalia
Saieva, Calogero
Pala, Valeria
Sieri, Sabina
Frasca, Graziella
Masala, Giovanna
Panico, Salvatore
Krogh, Vittorio
AuthorAffiliation University College London, UNITED KINGDOM
1 Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
8 Laboratory of Molecular and Nutritional Epidemiology. Department of Epidemiology and Prevention, IRCCS Istituto Neurologico Mediterraneo, Pozzilli, Italy
3 Unit of Cancer Epidemiology, University of Turin and Center for Cancer Prevention, Turin, Italy
2 Human Genetics Foundation, Turin, Italy
6 Department of Medicine and Public Health, Second University of Naples, Naples, Italy
7 Cancer Registry, Department of Prevention, Provincial Health Centre 7, Ragusa, Italy
9 School of Public Health, Imperial College, London, United Kingdom
5 Department of Clinical and Experimental Medicine, University of Naples Federico II, Naples, Italy
4 Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute (ISPO), Florence, Italy
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/25946046$$D View this record in MEDLINE/PubMed
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DocumentTitleAlternate Espresso Coffee Consumption and Risk of Coronary Heart Disease
EISSN 1932-6203
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Conceived and designed the experiments: SG CA VK SS SP. Performed the experiments: LI ADC. Analyzed the data: SG. Contributed reagents/materials/analysis tools: LI ADC. Wrote the paper: SG VK CA SS. Reviewed the manuscript for important intellectual content: VP RT GF FR PV GM CS PC AM.
Competing Interests: The authors have declared that no competing interests exist
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11207153 - Am J Epidemiol. 2001 Feb 15;153(4):353-62
20386010 - Arch Intern Med. 2010 Apr 12;170(7):640-7
20125186 - Eur J Clin Nutr. 2010 May;64(5):483-9
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SSID ssj0053866
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Snippet The relationship between coffee consumption and coronary heart disease (CHD) has been investigated in several studies with discrepant results. We examined the...
Background The relationship between coffee consumption and coronary heart disease (CHD) has been investigated in several studies with discrepant results. We...
Background The relationship between coffee consumption and coronary heart disease (CHD) has been investigated in several studies with discrepant results. We...
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SourceType Open Website
Open Access Repository
Aggregation Database
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Enrichment Source
StartPage e0126550
SubjectTerms Adult
Aged
Caffeine
Cancer
Cardiovascular disease
Cardiovascular diseases
Cholesterol
Coffee
Coffee (Beverage)
Coffee - adverse effects
Cohort Studies
Consumption
Coronary artery disease
Coronary Disease - chemically induced
Coronary Disease - epidemiology
Coronary heart disease
Cups
Diet
Disease prevention
Drinking
Epidemiology
Female
Health aspects
Health care
Health risk assessment
Health risks
Heart
Heart attacks
Heart diseases
High density lipoprotein
Homocysteine
Humans
Italy - epidemiology
Laboratories
Life Style
Lipids
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Title Espresso Coffee Consumption and Risk of Coronary Heart Disease in a Large Italian Cohort
URI https://www.ncbi.nlm.nih.gov/pubmed/25946046
https://www.proquest.com/docview/1679179195
https://www.proquest.com/docview/1680193016
https://pubmed.ncbi.nlm.nih.gov/PMC4422699
https://doaj.org/article/3412c18f477840af851204b508248475
http://dx.doi.org/10.1371/journal.pone.0126550
Volume 10
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