Serum syndecan-1 concentration in hospitalized patients with heart failure may predict readmission-free survival

Syndecan-1 is found in the endothelial glycocalyx and is released into the bloodstream during stressed conditions, including severe diseases such as acute kidney injury, chronic kidney disease, and cardiovascular disease. This study investigated the prognostic value of serum syndecan-1 concentration...

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Published inPloS one Vol. 16; no. 12; p. e0260350
Main Authors Kitagawa, Yuichiro, Kawamura, Itta, Suzuki, Keiko, Okada, Hideshi, Ishihara, Takuma, Tomita, Hiroyuki, Suzuki, Kodai, Takada, Chihiro, Sampei, So, Kano, Soichiro, Kondo, Kohei, Asano, Hirotaka, Wakayama, Yugo, Kamidani, Ryo, Kawasaki, Yuki, Fukuda, Hirotsugu, Nishio, Ayane, Miyake, Takahito, Fukuta, Tetsuya, Yasuda, Ryu, Oiwa, Hideaki, Kakino, Yoshinori, Miyazaki, Nagisa, Watanabe, Takatomo, Yoshida, Takahiro, Doi, Tomoaki, Suzuki, Akio, Yoshida, Shozo, Matsuo, Hitoshi, Ogura, Shinji
Format Journal Article
LanguageEnglish
Published United States Public Library of Science 08.12.2021
Public Library of Science (PLoS)
Subjects
Aged
Aged, 80 and over
Antibiotics
Atrial natriuretic peptide
Biology and Life Sciences
Biomarkers - blood
Blood
Cardiovascular diseases
Care and treatment
Cholesterol
Congestive heart failure
Creatinine
Echocardiography
Ejection fraction
Emergency medical care
Endothelium
Enzymes
Female
Health aspects
Heart failure
Heart Failure - blood
Hemoglobin
Heparan sulfate
Hospital patients
Hospitalization
Hospitals
Humans
Kidney diseases
Kidneys
Kinases
Male
Medical prognosis
Medicine
Medicine and Health Sciences
Patient outcomes
Patient Readmission - statistics & numerical data
Patients
Peptides
Permeability
Pharmacy
Pleural effusion
Prognosis
Proteins
Regression analysis
Survival
Survival Analysis
Syndecan
Syndecan-1 - blood
Time dependence
Treatment Outcome
University graduates
Japan
Online AccessGet full text

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Abstract Syndecan-1 is found in the endothelial glycocalyx and is released into the bloodstream during stressed conditions, including severe diseases such as acute kidney injury, chronic kidney disease, and cardiovascular disease. This study investigated the prognostic value of serum syndecan-1 concentration in patients with heart failure upon admission. Serum syndecan-1 concentration was analyzed in 152 patients who were hospitalized for worsening heart failure from September 2017 to June 2018. The primary outcome of the study was readmission-free survival, defined as the time from the first admission to readmission for worsened heart failure or death from any cause, which was assessed at 30 months after discharge from the hospital. The secondary outcome of the study was survival time. Blood samples and echocardiogram data were analyzed. Univariate and multivariable time-dependent Cox regression analyses adjusted for age, creatinine levels, and use of antibiotics were conducted. The serum syndecan-1 concentration was significantly associated with readmission-free survival. Subsequently, the syndecan-1 concentration may have gradually decreased with treatment. The administration of human atrial natriuretic peptide and antibiotics may have modified the relationship between readmission-free survival and serum syndecan-1 concentration (p = 0.01 and 0.008, respectively). Serum syndecan-1 concentrations, which may indicate injury to the endothelial glycocalyx, predict readmission-free survival in patients with heart failure.
AbstractList Syndecan-1 is found in the endothelial glycocalyx and is released into the bloodstream during stressed conditions, including severe diseases such as acute kidney injury, chronic kidney disease, and cardiovascular disease. This study investigated the prognostic value of serum syndecan-1 concentration in patients with heart failure upon admission. Serum syndecan-1 concentration was analyzed in 152 patients who were hospitalized for worsening heart failure from September 2017 to June 2018. The primary outcome of the study was readmission-free survival, defined as the time from the first admission to readmission for worsened heart failure or death from any cause, which was assessed at 30 months after discharge from the hospital. The secondary outcome of the study was survival time. Blood samples and echocardiogram data were analyzed. Univariate and multivariable time-dependent Cox regression analyses adjusted for age, creatinine levels, and use of antibiotics were conducted. The serum syndecan-1 concentration was significantly associated with readmission-free survival. Subsequently, the syndecan-1 concentration may have gradually decreased with treatment. The administration of human atrial natriuretic peptide and antibiotics may have modified the relationship between readmission-free survival and serum syndecan-1 concentration (p = 0.01 and 0.008, respectively). Serum syndecan-1 concentrations, which may indicate injury to the endothelial glycocalyx, predict readmission-free survival in patients with heart failure.
Syndecan-1 is found in the endothelial glycocalyx and is released into the bloodstream during stressed conditions, including severe diseases such as acute kidney injury, chronic kidney disease, and cardiovascular disease. This study investigated the prognostic value of serum syndecan-1 concentration in patients with heart failure upon admission. Serum syndecan-1 concentration was analyzed in 152 patients who were hospitalized for worsening heart failure from September 2017 to June 2018. The primary outcome of the study was readmission-free survival, defined as the time from the first admission to readmission for worsened heart failure or death from any cause, which was assessed at 30 months after discharge from the hospital. The secondary outcome of the study was survival time. Blood samples and echocardiogram data were analyzed. Univariate and multivariable time-dependent Cox regression analyses adjusted for age, creatinine levels, and use of antibiotics were conducted. The serum syndecan-1 concentration was significantly associated with readmission-free survival. Subsequently, the syndecan-1 concentration may have gradually decreased with treatment. The administration of human atrial natriuretic peptide and antibiotics may have modified the relationship between readmission-free survival and serum syndecan-1 concentration (p = 0.01 and 0.008, respectively). Serum syndecan-1 concentrations, which may indicate injury to the endothelial glycocalyx, predict readmission-free survival in patients with heart failure.Syndecan-1 is found in the endothelial glycocalyx and is released into the bloodstream during stressed conditions, including severe diseases such as acute kidney injury, chronic kidney disease, and cardiovascular disease. This study investigated the prognostic value of serum syndecan-1 concentration in patients with heart failure upon admission. Serum syndecan-1 concentration was analyzed in 152 patients who were hospitalized for worsening heart failure from September 2017 to June 2018. The primary outcome of the study was readmission-free survival, defined as the time from the first admission to readmission for worsened heart failure or death from any cause, which was assessed at 30 months after discharge from the hospital. The secondary outcome of the study was survival time. Blood samples and echocardiogram data were analyzed. Univariate and multivariable time-dependent Cox regression analyses adjusted for age, creatinine levels, and use of antibiotics were conducted. The serum syndecan-1 concentration was significantly associated with readmission-free survival. Subsequently, the syndecan-1 concentration may have gradually decreased with treatment. The administration of human atrial natriuretic peptide and antibiotics may have modified the relationship between readmission-free survival and serum syndecan-1 concentration (p = 0.01 and 0.008, respectively). Serum syndecan-1 concentrations, which may indicate injury to the endothelial glycocalyx, predict readmission-free survival in patients with heart failure.
Audience Academic
Author Wakayama, Yugo
Miyazaki, Nagisa
Matsuo, Hitoshi
Suzuki, Keiko
Okada, Hideshi
Watanabe, Takatomo
Miyake, Takahito
Takada, Chihiro
Kano, Soichiro
Tomita, Hiroyuki
Oiwa, Hideaki
Fukuda, Hirotsugu
Kitagawa, Yuichiro
Suzuki, Akio
Fukuta, Tetsuya
Doi, Tomoaki
Kondo, Kohei
Kakino, Yoshinori
Ogura, Shinji
Ishihara, Takuma
Asano, Hirotaka
Kawamura, Itta
Suzuki, Kodai
Sampei, So
Kawasaki, Yuki
Yoshida, Takahiro
Yasuda, Ryu
Yoshida, Shozo
Nishio, Ayane
Kamidani, Ryo
AuthorAffiliation 7 Department of Internal Medicine, Asahi University School of Dentistry, Mizuho, Japan
Scuola Superiore Sant’Anna, ITALY
2 Gifu Heart Center, Gifu, Japan
5 Department of Tumor Pathology, Gifu University Graduate School of Medicine, Gifu, Japan
6 Department of Abuse Prevention Emergency Medicine, Gifu University Graduate School of Medicine, Gifu, Japan
3 Department of Pharmacy, Gifu University Hospital, Gifu, Japan
4 Innovative and Clinical Research Promotion Center, Gifu University Hospital, Gifu, Japan
8 Department of Clinical Laboratory, Gifu University Hospital, Gifu, Japan
1 Department of Emergency and Disaster Medicine, Gifu University Graduate School of Medicine, Gifu, Japan
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/34879094$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1186/s13054-015-0741-z
10.1161/HYPERTENSIONAHA.109.137885
10.1152/ajpheart.00602.2015
10.1100/tsw.2010.88
10.1097/CRD.0b013e3182769073
10.1186/s13054-015-0918-5
10.1161/01.CIR.0000144310.04433.BE
10.1056/NEJMcibr1007320
10.1186/s13054-017-1841-8
10.1073/pnas.92.24.11190
10.1056/NEJMoa020233
10.1161/CIRCHEARTFAILURE.113.000846
10.1016/j.pcad.2012.05.004
10.1136/bmj.2.5402.177
10.1093/bja/aer515
10.1186/cc11239
10.1097/00000542-200405000-00025
10.1146/annurev-cellbio-100109-104126
10.1056/NEJMoa0708789
10.1034/j.1399-6576.2002.460207.x
10.1039/c2mb25021g
10.1016/j.jcrc.2016.06.027
10.1007/s00395-010-0118-z
10.1016/j.ceb.2009.05.002
10.1016/S0735-1097(98)00407-0
10.4269/ajtmh.14-0232
10.1111/j.1742-4658.2010.07798.x
10.1253/circj.CJ-18-0523
10.1016/S0140-6736(14)62000-6
10.1007/s00424-007-0212-8
10.1038/s41598-018-35976-2
10.1038/s41598-021-88303-7
10.1152/japplphysiol.91013.2008
10.3109/1354750X.2011.587893
10.1146/annurev.publhealth.20.1.145
10.1016/j.chest.2018.03.003
10.1002/path.3964
10.1620/tjem.250.233
10.1016/S0735-1097(01)01663-1
10.1016/j.matbio.2011.10.001
10.1093/eurheartj/ehw128
10.1152/ajpheart.01160.2005
10.1016/j.atherosclerosis.2014.03.016
10.1161/CIRCULATIONAHA.106.684852
10.1016/S0735-1097(00)00912-8
10.1152/ajpheart.00104.2018
10.1007/s13539-014-0135-0
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References P Verdecchia (pone.0260350.ref049) 2001; 38
Y Ando (pone.0260350.ref029) 2018; 8
K Maeda (pone.0260350.ref007) 2000; 36
YH Teng (pone.0260350.ref043) 2012; 31
M Rehm (pone.0260350.ref013) 2004; 100
JH Luft (pone.0260350.ref011) 1966; 25
K Oda (pone.0260350.ref033) 2019; 8
JR Couchman (pone.0260350.ref039) 2010; 26
AP Kalogeropoulos (pone.0260350.ref003) 2012; 55
Y Huo (pone.0260350.ref047) 2009; 107
E Chang (pone.0260350.ref048) 1995; 92
MA Puskarich (pone.0260350.ref028) 2016; 36
DP Leong (pone.0260350.ref046) 2015; 386
AB Liborio (pone.0260350.ref034) 2015; 92
K Suzuki (pone.0260350.ref036) 2021; 11
PP Rickham (pone.0260350.ref038) 1964; 2
SM Joseph (pone.0260350.ref002) 2009; 36
BF Becker (pone.0260350.ref012) 2010; 105
H Okada (pone.0260350.ref020) 2017; 21
D Roy (pone.0260350.ref051) 2008; 358
JS Padberg (pone.0260350.ref035) 2014; 234
T Manon-Jensen (pone.0260350.ref041) 2010; 277
P Paulus (pone.0260350.ref024) 2011; 16
M Henrich (pone.0260350.ref019) 2010; 10
AW Haider (pone.0260350.ref050) 1998; 32
SR Motiwala (pone.0260350.ref004) 2013; 21
VT Mitic (pone.0260350.ref031) 2020; 250
A Burke-Gaffney (pone.0260350.ref037) 2012; 16
P Bettencourt (pone.0260350.ref006) 2004; 110
S Mangini (pone.0260350.ref001) 2013; 11
AS Maisel (pone.0260350.ref005) 2002; 347
K Lambaerts (pone.0260350.ref040) 2009; 21
Y Nakada (pone.0260350.ref008) 2016; 310
AH Salmon (pone.0260350.ref025) 2012; 226
X Zhang (pone.0260350.ref021) 2006; 291
L Li (pone.0260350.ref023) 2012; 8
C Chelazzi (pone.0260350.ref018) 2015; 19
J Tromp (pone.0260350.ref030) 2014; 7
MW Schellings (pone.0260350.ref042) 2010; 55
DR Machin (pone.0260350.ref032) 2018; 315
P Ponikowski (pone.0260350.ref010) 2016; 37
S Reitsma (pone.0260350.ref017) 2007; 454
TE Woodcock (pone.0260350.ref014) 2012; 108
AC Frati-Munari (pone.0260350.ref015) 2013; 83
S Berg (pone.0260350.ref022) 2002; 46
SD Anker (pone.0260350.ref045) 2014; 5
LD Fisher (pone.0260350.ref052) 1999; 20
R Inagawa (pone.0260350.ref044) 2018; 154
WL Lee (pone.0260350.ref016) 2010; 363
SR Ostrowski (pone.0260350.ref027) 2015; 19
M Rehm (pone.0260350.ref026) 2007; 116
Y Nakada (pone.0260350.ref009) 2019; 83
References_xml – volume: 19
  start-page: 26
  year: 2015
  ident: pone.0260350.ref018
  article-title: Glycocalyx and sepsis-induced alterations in vascular permeability
  publication-title: Crit Care
  doi: 10.1186/s13054-015-0741-z
– volume: 55
  start-page: 249
  issue: 2
  year: 2010
  ident: pone.0260350.ref042
  article-title: Syndecan-1 amplifies angiotensin II-induced cardiac fibrosis
  publication-title: Hypertension
  doi: 10.1161/HYPERTENSIONAHA.109.137885
– volume: 310
  start-page: H813
  issue: 7
  year: 2016
  ident: pone.0260350.ref008
  article-title: Sex differences in clinical characteristics and long-term outcome in acute decompensated heart failure patients with preserved and reduced ejection fraction
  publication-title: Am J Physiol Heart Circ Physiol
  doi: 10.1152/ajpheart.00602.2015
– volume: 10
  start-page: 917
  year: 2010
  ident: pone.0260350.ref019
  article-title: Sepsis-induced degradation of endothelial glycocalix
  publication-title: ScientificWorldJournal
  doi: 10.1100/tsw.2010.88
– volume: 21
  start-page: 127
  issue: 3
  year: 2013
  ident: pone.0260350.ref004
  article-title: Using biomarkers to "guide" heart failure management: current perspectives and future directions
  publication-title: Cardiol Rev
  doi: 10.1097/CRD.0b013e3182769073
– volume: 19
  start-page: 191
  year: 2015
  ident: pone.0260350.ref027
  article-title: Association between biomarkers of endothelial injury and hypocoagulability in patients with severe sepsis: a prospective study
  publication-title: Crit Care
  doi: 10.1186/s13054-015-0918-5
– volume: 110
  start-page: 2168
  issue: 15
  year: 2004
  ident: pone.0260350.ref006
  article-title: N-terminal-pro-brain natriuretic peptide predicts outcome after hospital discharge in heart failure patients
  publication-title: Circulation
  doi: 10.1161/01.CIR.0000144310.04433.BE
– volume: 363
  start-page: 689
  issue: 7
  year: 2010
  ident: pone.0260350.ref016
  article-title: Sepsis and endothelial permeability
  publication-title: N Engl J Med
  doi: 10.1056/NEJMcibr1007320
– volume: 21
  start-page: 261
  issue: 1
  year: 2017
  ident: pone.0260350.ref020
  article-title: Three-dimensional ultrastructure of capillary endothelial glycocalyx under normal and experimental endotoxemic conditions
  publication-title: Crit Care
  doi: 10.1186/s13054-017-1841-8
– volume: 25
  start-page: 1773
  issue: 6
  year: 1966
  ident: pone.0260350.ref011
  article-title: Fine structures of capillary and endocapillary layer as revealed by ruthenium red
  publication-title: Fed Proc
– volume: 92
  start-page: 11190
  issue: 24
  year: 1995
  ident: pone.0260350.ref048
  article-title: Telomere length and replicative aging in human vascular tissues
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.92.24.11190
– volume: 347
  start-page: 161
  issue: 3
  year: 2002
  ident: pone.0260350.ref005
  article-title: Rapid measurement of B-type natriuretic peptide in the emergency diagnosis of heart failure
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa020233
– volume: 7
  start-page: 457
  issue: 3
  year: 2014
  ident: pone.0260350.ref030
  article-title: Fibrosis marker syndecan-1 and outcome in patients with heart failure with reduced and preserved ejection fraction
  publication-title: Circ Heart Fail
  doi: 10.1161/CIRCHEARTFAILURE.113.000846
– volume: 55
  start-page: 3
  issue: 1
  year: 2012
  ident: pone.0260350.ref003
  article-title: Clinical adoption of prognostic biomarkers: the case for heart failure
  publication-title: Prog Cardiovasc Dis
  doi: 10.1016/j.pcad.2012.05.004
– volume: 2
  start-page: 177
  issue: 5402
  year: 1964
  ident: pone.0260350.ref038
  article-title: Human Experimentation. Code of Ethics of the World Medical Association. Declaration of Helsinki
  publication-title: Br Med J
  doi: 10.1136/bmj.2.5402.177
– volume: 108
  start-page: 384
  issue: 3
  year: 2012
  ident: pone.0260350.ref014
  article-title: Revised Starling equation and the glycocalyx model of transvascular fluid exchange: an improved paradigm for prescribing intravenous fluid therapy
  publication-title: Br J Anaesth
  doi: 10.1093/bja/aer515
– volume: 16
  start-page: 121
  issue: 2
  year: 2012
  ident: pone.0260350.ref037
  article-title: Lest we forget the endothelial glycocalyx in sepsis
  publication-title: Crit Care
  doi: 10.1186/cc11239
– volume: 36
  start-page: 510
  issue: 6
  year: 2009
  ident: pone.0260350.ref002
  article-title: Acute decompensated heart failure: contemporary medical management
  publication-title: Tex Heart Inst J
– volume: 100
  start-page: 1211
  issue: 5
  year: 2004
  ident: pone.0260350.ref013
  article-title: Endothelial glycocalyx as an additional barrier determining extravasation of 6% hydroxyethyl starch or 5% albumin solutions in the coronary vascular bed
  publication-title: Anesthesiology
  doi: 10.1097/00000542-200405000-00025
– volume: 26
  start-page: 89
  year: 2010
  ident: pone.0260350.ref039
  article-title: Transmembrane signaling proteoglycans
  publication-title: Annu Rev Cell Dev Biol
  doi: 10.1146/annurev-cellbio-100109-104126
– volume: 358
  start-page: 2667
  issue: 25
  year: 2008
  ident: pone.0260350.ref051
  article-title: Rhythm control versus rate control for atrial fibrillation and heart failure
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa0708789
– volume: 46
  start-page: 166
  issue: 2
  year: 2002
  ident: pone.0260350.ref022
  article-title: Albumin extravasation and tissue washout of hyaluronan after plasma volume expansion with crystalloid or hypooncotic colloid solutions
  publication-title: Acta Anaesthesiol Scand
  doi: 10.1034/j.1399-6576.2002.460207.x
– volume: 8
  start-page: 1613
  issue: 6
  year: 2012
  ident: pone.0260350.ref023
  article-title: Proteoglycan sequence
  publication-title: Mol Biosyst
  doi: 10.1039/c2mb25021g
– volume: 36
  start-page: 125
  year: 2016
  ident: pone.0260350.ref028
  article-title: Plasma syndecan-1 levels identify a cohort of patients with severe sepsis at high risk for intubation after large-volume intravenous fluid resuscitation
  publication-title: J Crit Care
  doi: 10.1016/j.jcrc.2016.06.027
– volume: 105
  start-page: 687
  issue: 6
  year: 2010
  ident: pone.0260350.ref012
  article-title: Endothelial glycocalyx and coronary vascular permeability: the fringe benefit
  publication-title: Basic Res Cardiol
  doi: 10.1007/s00395-010-0118-z
– volume: 21
  start-page: 662
  issue: 5
  year: 2009
  ident: pone.0260350.ref040
  article-title: The signaling mechanisms of syndecan heparan sulfate proteoglycans
  publication-title: Curr Opin Cell Biol
  doi: 10.1016/j.ceb.2009.05.002
– volume: 32
  start-page: 1454
  issue: 5
  year: 1998
  ident: pone.0260350.ref050
  article-title: Increased left ventricular mass and hypertrophy are associated with increased risk for sudden death
  publication-title: J Am Coll Cardiol
  doi: 10.1016/S0735-1097(98)00407-0
– volume: 92
  start-page: 611
  issue: 3
  year: 2015
  ident: pone.0260350.ref034
  article-title: Endothelial glycocalyx damage is associated with leptospirosis acute kidney injury
  publication-title: Am J Trop Med Hyg
  doi: 10.4269/ajtmh.14-0232
– volume: 277
  start-page: 3876
  issue: 19
  year: 2010
  ident: pone.0260350.ref041
  article-title: Proteoglycans in health and disease: the multiple roles of syndecan shedding
  publication-title: FEBS J
  doi: 10.1111/j.1742-4658.2010.07798.x
– volume: 83
  start-page: 395
  issue: 2
  year: 2019
  ident: pone.0260350.ref009
  article-title: Value of Placental Growth Factor as a Predictor of Adverse Events During the Acute Phase of Acute Decompensated Heart Failure
  publication-title: Circ J
  doi: 10.1253/circj.CJ-18-0523
– volume: 386
  start-page: 266
  issue: 9990
  year: 2015
  ident: pone.0260350.ref046
  article-title: Prognostic value of grip strength: findings from the Prospective Urban Rural Epidemiology (PURE) study
  publication-title: Lancet
  doi: 10.1016/S0140-6736(14)62000-6
– volume: 454
  start-page: 345
  issue: 3
  year: 2007
  ident: pone.0260350.ref017
  article-title: The endothelial glycocalyx: composition, functions, and visualization
  publication-title: Pflugers Arch
  doi: 10.1007/s00424-007-0212-8
– volume: 8
  start-page: 17523
  issue: 1
  year: 2018
  ident: pone.0260350.ref029
  article-title: Brain-Specific Ultrastructure of Capillary Endothelial Glycocalyx and Its Possible Contribution for Blood Brain Barrier
  publication-title: Sci Rep
  doi: 10.1038/s41598-018-35976-2
– volume: 11
  start-page: 8864
  issue: 1
  year: 2021
  ident: pone.0260350.ref036
  article-title: Serum syndecan-1 reflects organ dysfunction in critically ill patients
  publication-title: Sci Rep
  doi: 10.1038/s41598-021-88303-7
– volume: 107
  start-page: 500
  issue: 2
  year: 2009
  ident: pone.0260350.ref047
  article-title: Effect of compliance and hematocrit on wall shear stress in a model of the entire coronary arterial tree
  publication-title: J Appl Physiol (1985)
  doi: 10.1152/japplphysiol.91013.2008
– volume: 16
  start-page: S11
  issue: Suppl 1
  year: 2011
  ident: pone.0260350.ref024
  article-title: Biomarkers of endothelial dysfunction: can they help us deciphering systemic inflammation and sepsis?
  publication-title: Biomarkers
  doi: 10.3109/1354750X.2011.587893
– volume: 20
  start-page: 145
  year: 1999
  ident: pone.0260350.ref052
  article-title: Time-dependent covariates in the Cox proportional-hazards regression model
  publication-title: Annu Rev Public Health
  doi: 10.1146/annurev.publhealth.20.1.145
– volume: 154
  start-page: 317
  issue: 2
  year: 2018
  ident: pone.0260350.ref044
  article-title: Ultrastructural Alteration of Pulmonary Capillary Endothelial Glycocalyx During Endotoxemia
  publication-title: Chest
  doi: 10.1016/j.chest.2018.03.003
– volume: 226
  start-page: 562
  issue: 4
  year: 2012
  ident: pone.0260350.ref025
  article-title: Endothelial glycocalyx dysfunction in disease: albuminuria and increased microvascular permeability
  publication-title: J Pathol
  doi: 10.1002/path.3964
– volume: 250
  start-page: 233
  issue: 4
  year: 2020
  ident: pone.0260350.ref031
  article-title: Cardiac Remodeling Biomarkers as Potential Circulating Markers of Left Ventricular Hypertrophy in Heart Failure with Preserved Ejection Fraction
  publication-title: Tohoku J Exp Med
  doi: 10.1620/tjem.250.233
– volume: 38
  start-page: 1829
  issue: 7
  year: 2001
  ident: pone.0260350.ref049
  article-title: Left ventricular mass and cardiovascular morbidity in essential hypertension: the MAVI study
  publication-title: J Am Coll Cardiol
  doi: 10.1016/S0735-1097(01)01663-1
– volume: 11
  start-page: 383
  issue: 3
  year: 2013
  ident: pone.0260350.ref001
  article-title: Decompensated heart failure
  publication-title: Einstein (Sao Paulo)
– volume: 31
  start-page: 3
  issue: 1
  year: 2012
  ident: pone.0260350.ref043
  article-title: Molecular functions of syndecan-1 in disease
  publication-title: Matrix Biol
  doi: 10.1016/j.matbio.2011.10.001
– volume: 8
  issue: 9
  year: 2019
  ident: pone.0260350.ref033
  article-title: Factors Enhancing Serum Syndecan-1 Concentrations: A Large-Scale Comprehensive Medical Examination
  publication-title: J Clin Med
– volume: 37
  start-page: 2129
  issue: 27
  year: 2016
  ident: pone.0260350.ref010
  article-title: 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC)Developed with the special contribution of the Heart Failure Association (HFA) of the ESC
  publication-title: Eur Heart J
  doi: 10.1093/eurheartj/ehw128
– volume: 291
  start-page: H2950
  issue: 6
  year: 2006
  ident: pone.0260350.ref021
  article-title: A 1-D model to explore the effects of tissue loading and tissue concentration gradients in the revised Starling principle
  publication-title: Am J Physiol Heart Circ Physiol
  doi: 10.1152/ajpheart.01160.2005
– volume: 83
  start-page: 303
  issue: 4
  year: 2013
  ident: pone.0260350.ref015
  article-title: Medical significance of endothelial glycocalyx
  publication-title: Arch Cardiol Mex
– volume: 234
  start-page: 335
  issue: 2
  year: 2014
  ident: pone.0260350.ref035
  article-title: Damage of the endothelial glycocalyx in chronic kidney disease
  publication-title: Atherosclerosis
  doi: 10.1016/j.atherosclerosis.2014.03.016
– volume: 116
  start-page: 1896
  issue: 17
  year: 2007
  ident: pone.0260350.ref026
  article-title: Shedding of the endothelial glycocalyx in patients undergoing major vascular surgery with global and regional ischemia
  publication-title: Circulation
  doi: 10.1161/CIRCULATIONAHA.106.684852
– volume: 36
  start-page: 1587
  issue: 5
  year: 2000
  ident: pone.0260350.ref007
  article-title: High levels of plasma brain natriuretic peptide and interleukin-6 after optimized treatment for heart failure are independent risk factors for morbidity and mortality in patients with congestive heart failure
  publication-title: J Am Coll Cardiol
  doi: 10.1016/S0735-1097(00)00912-8
– volume: 315
  start-page: H531
  issue: 3
  year: 2018
  ident: pone.0260350.ref032
  article-title: Advanced age results in a diminished endothelial glycocalyx
  publication-title: Am J Physiol Heart Circ Physiol
  doi: 10.1152/ajpheart.00104.2018
– volume: 5
  start-page: 1
  issue: 1
  year: 2014
  ident: pone.0260350.ref045
  article-title: Muscle wasting disease: a proposal for a new disease classification
  publication-title: J Cachexia Sarcopenia Muscle
  doi: 10.1007/s13539-014-0135-0
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Snippet Syndecan-1 is found in the endothelial glycocalyx and is released into the bloodstream during stressed conditions, including severe diseases such as acute...
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StartPage e0260350
SubjectTerms Aged
Aged, 80 and over
Antibiotics
Atrial natriuretic peptide
Biology and Life Sciences
Biomarkers - blood
Blood
Cardiovascular diseases
Care and treatment
Cholesterol
Congestive heart failure
Creatinine
Echocardiography
Ejection fraction
Emergency medical care
Endothelium
Enzymes
Female
Health aspects
Heart failure
Heart Failure - blood
Hemoglobin
Heparan sulfate
Hospital patients
Hospitalization
Hospitals
Humans
Kidney diseases
Kidneys
Kinases
Male
Medical prognosis
Medicine
Medicine and Health Sciences
Patient outcomes
Patient Readmission - statistics & numerical data
Patients
Peptides
Permeability
Pharmacy
Pleural effusion
Prognosis
Proteins
Regression analysis
Survival
Survival Analysis
Syndecan
Syndecan-1 - blood
Time dependence
Treatment Outcome
University graduates
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Title Serum syndecan-1 concentration in hospitalized patients with heart failure may predict readmission-free survival
URI https://www.ncbi.nlm.nih.gov/pubmed/34879094
https://www.proquest.com/docview/2608084561
https://www.proquest.com/docview/2608452738
https://pubmed.ncbi.nlm.nih.gov/PMC8654157
https://doaj.org/article/66aabae8b21b4adfb1f1c847941f5f88
http://dx.doi.org/10.1371/journal.pone.0260350
Volume 16
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