Pericardial- Rather than Intramyocardial Fat Is Independently Associated with Left Ventricular Systolic Heart Function in Metabolically Healthy Humans

• Published in: PloS one Vol. 11; no. 3; p. e0151301
• Main Authors: Wolf, Peter, Winhofer, Yvonne, Smajis, Sabina, Jankovic, Draženka, Anderwald, Christian-Heinz, Trattnig, Siegfried, Luger, Anton, Krebs, Michael, Krššák, Martin
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 11.03.2016; Public Library of Science (PLoS)
• Subjects: Adiposity; Adult; Anthropometry; Biology and Life Sciences; Body mass; Body Mass Index; Cardiology; Care and treatment; Complications and side effects; Correlation; Correlation analysis; Correlation coefficient; Correlation coefficients; Diabetes; Diagnosis; Endocrinology; Energy metabolism; Feasibility studies; Female; Gastrointestinal surgery; Glucose metabolism; Heart - diagnostic imaging; Heart diseases; Heart failure; Heart function; Heart Rate; Humans; Insulin resistance; Internal medicine; Linear Models; Lipid Metabolism; Lipids; Liver diseases; Magnetic resonance; Magnetic Resonance Imaging; Magnetic resonance spectroscopy; Male; Medicine; Medicine and Health Sciences; Metabolic diseases; Metabolic disorders; Metabolism; Multiple regression analysis; Myocardium - metabolism; Obesity; Paracrine signalling; Pericardium - metabolism; Regression analysis; Regression models; Risk factors; Spectroscopy; Stroke; Stroke Volume; Ventricle; Ventricular Function, Left - physiology; Young Adult; Austria

Obesity is a major risk factor to develop heart failure, in part due to possible lipotoxic effects of increased intramyocardial (MYCL) and/or local or paracrine effects of pericardial (PERI) lipid accumulation. Recent evidence suggests that MYCL is highly dynamic and might rather be a surrogate mark...