Unraveling the molecular pathobiology of vocal fold systemic dehydration using an in vivo rabbit model

• Published in: PloS one Vol. 15; no. 7; p. e0236348
• Main Authors: Cannes do Nascimento, Naila, dos Santos, Andrea P., Sivasankar, M. Preeti, Cox, Abigail
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 31.07.2020; Public Library of Science (PLoS)
• Subjects: Animals; Biology; Biology and Life Sciences; Biomechanical Phenomena; Biomechanics; Cell adhesion; Cell adhesion & migration; Cell Adhesion - genetics; Cell proliferation; Cell Proliferation - genetics; Dehydration; Dehydration (Physiology); Dehydration - genetics; Dehydration - metabolism; Dehydration - pathology; Disease Models, Animal; Epithelial cells; Epithelial Cells - metabolism; Epithelial Cells - pathology; Experiments; Food; Gene expression; Gene Expression Regulation - genetics; Genes; Genetic aspects; Genotypes; Human subjects; Humans; Hydration; In vivo methods and tests; Intercellular Junctions - genetics; Interleukin 1; Laboratory animals; Lamina propria; Laryngeal Muscles - metabolism; Laryngeal Muscles - pathology; Medicine and Health Sciences; Mucous Membrane - metabolism; Mucous Membrane - pathology; Muscles; Observations; Proteins; Rabbits; Research and Analysis Methods; Ribonucleic acid; RNA; Studies; Vibration; Viscoelasticity; Vocal cords; Vocal Cords - metabolism; Vocal Cords - pathology; Vocal organs; Voice; Voice Disorders - genetics; Voice Disorders - pathology; United States; Indiana; United States > US

Vocal folds are a viscoelastic multilayered structure responsible for voice production. Vocal fold epithelial damage may weaken the protection of deeper layers of lamina propria and thyroarytenoid muscle and impair voice production. Systemic dehydration can adversely affect vocal function by creatin...