The classical pink-eyed dilution mutation affects angiogenic responsiveness

• Published in: PloS one Vol. 7; no. 5; p. e35237
• Main Authors: Rogers, Michael S, Boyartchuk, Victor, Rohan, Richard M, Birsner, Amy E, Dietrich, William F, D'Amato, Robert J
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 15.05.2012; Public Library of Science (PLoS)
• Subjects: Alleles; Angiogenesis; Animal models; Animals; Biology; Blood vessels; Breeding; Cancer; Chromosome 7; Cornea; Dilution; Disease susceptibility; Dopamine; Eye Color - genetics; Fibroblast growth factor 2; Fibroblast growth factors; Gene mapping; Genes; Genetic aspects; Genetic diversity; Genetic polymorphisms; Genomes; Genomics; Haplotypes; Heart; House mouse; Hypoxia; Ischemia; Laboratory animals; Laboratory tests; Mapping; Medical schools; Medicine; Melanoma; Mice; Mice, Inbred C57BL; Mutation; Neovascularization; Neovascularization, Physiologic - genetics; Nucleotide sequence; Permeability; Polymorphism; Polymorphism, Genetic; Proteins; Quantitative trait loci; Rodents; Smooth muscle; Stability; Vascular endothelial growth factor; Vascularization; United States > US; Massachusetts

Angiogenesis is the process by which new blood vessels are formed from existing vessels. Mammalian populations, including humans and mice, harbor genetic variations that alter angiogenesis. Angiogenesis-regulating gene variants can result in increased susceptibility to multiple angiogenesis-dependen...