Ozone effects on blood biomarkers of systemic inflammation, oxidative stress, endothelial function, and thrombosis: The Multicenter Ozone Study in oldEr Subjects (MOSES)

• Published in: PloS one Vol. 14; no. 9; p. e0222601
• Main Authors: Balmes, John R., Arjomandi, Mehrdad, Bromberg, Philip A., Costantini, Maria G., Dagincourt, Nicholas, Hazucha, Milan J., Hollenbeck-Pringle, Danielle, Rich, David Q., Stark, Paul, Frampton, Mark W.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 25.09.2019; Public Library of Science (PLoS)
• Subjects: Adults; Aged; Air Pollutants - adverse effects; Air pollution; Asthma; Atherosclerosis; Biological markers; Biology and Life Sciences; Biomarkers; Biomarkers - blood; Blood; C-reactive protein; C-Reactive Protein - analysis; Cardiovascular disease; Cardiovascular diseases; Care and treatment; Confidence intervals; Cross-Over Studies; Disease susceptibility; Dose-Response Relationship, Drug; Double-Blind Method; Earth Sciences; Ecology and Environmental Sciences; Elderly; Endothelin; Endothelin 1; Endothelins; Endothelium; Endothelium, Vascular - drug effects; Environmental health; Epidemiology; Exposure; Factor VII; Female; Genes; Genetic research; Glutathione; Glutathione transferase; GSTM1 protein; Health aspects; Health care; Health sciences; Humans; Inflammation; Inflammation - blood; Inflammation - chemically induced; Inhalation Exposure - adverse effects; Male; Medicine; Medicine and Health Sciences; Microparticles; Middle Aged; Monocytes; Morbidity; Mortality; Nitrotyrosine; Older people; Outdoor air quality; Oxidative stress; Oxidative Stress - drug effects; Ozone; Ozone - adverse effects; Ozone concentration; Ozone effects; Patient outcomes; Physical Sciences; Platelet Activation - drug effects; Pollutants; Pollution; Pollution effects; Pollution monitoring; Public health; Regression analysis; Regression models; Risk factors; Statistical analysis; Studies; Thromboembolism; Thrombosis; Thrombosis - chemically induced; Tissue factor; Young adults; United States > US; San Francisco California; California

The evidence that exposure to ozone air pollution causes acute cardiovascular effects is mixed. We postulated that exposure to ambient levels of ozone would increase blood markers of systemic inflammation, prothrombotic state, oxidative stress, and vascular dysfunction in healthy older subjects, and...