Early detection of neutralizing antibodies against SARS-CoV-2 in COVID-19 patients in Thailand

• Published in: PloS one Vol. 16; no. 2; p. e0246864
• Main Authors: Putcharoen, Opass, Wacharapluesadee, Supaporn, Chia, Wan Ni, Paitoonpong, Leilani, Tan, Chee Wah, Suwanpimolkul, Gompol, Jantarabenjakul, Watsamon, Ruchisrisarod, Chanida, Wanthong, Phanni, Sophonphan, Jiratchaya, Chariyavilaskul, Pajaree, Wang, Lin-Fa, Hemachudha, Thiravat
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 12.02.2021; Public Library of Science (PLoS)
• Subjects: Adult; Antibodies; Antibodies, Neutralizing - analysis; Antibodies, Neutralizing - isolation & purification; Antibodies, Viral - isolation & purification; Asymptomatic infection; Biology and life sciences; Contact tracing; Coronaviruses; Cough; COVID-19; COVID-19 - diagnosis; COVID-19 - immunology; COVID-19 Nucleic Acid Testing; COVID-19 Serological Testing - methods; Editing; Electronic mail; Female; Fever; HIV; Hospitals; Human immunodeficiency virus; Humans; Humoral immunity; Immune response; Immune system; Infections; Infectious diseases; Male; Measurement; Medicine; Medicine and health sciences; Metropolitan areas; Middle Aged; Myalgia; Neutralization Tests - methods; Nose; Olfaction; Pandemics; Patients; Pediatrics; Pharmacogenomics; Pharmacokinetics; Pharmacology; Pneumonia; Polymerase chain reaction; Public health; Research and Analysis Methods; SARS-CoV-2 - physiology; Sensitivity and Specificity; Serologic Tests; Serology; Severe acute respiratory syndrome; Severe acute respiratory syndrome coronavirus 2; Signs and symptoms; Smell; Spike Glycoprotein, Coronavirus - chemistry; Thailand; Training; Vaccines; Viral antibodies; Viral diseases; Viral infections; Viruses; Young Adult; Zoonoses; Thailand; Singapore; United States > US; Bangkok Thailand

The presence of neutralizing antibodies (NAbs) is an indicator of protective immunity for most viral infections. A newly developed surrogate viral neutralization assay (sVNT) offers the ability to detect total receptor binding domain-targeting NAbs in an isotype-independent manner, increasing the te...