Different adjuvanted pediatric HIV envelope vaccines induced distinct plasma antibody responses despite similar B cell receptor repertoires in infant rhesus macaques

• Published in: PloS one Vol. 16; no. 12; p. e0256885
• Main Authors: Berendam, Stella J, Morgan-Asiedu, Papa K, Mangan, Riley J, Li, Shuk Hang, Heimsath, Holly, Luo, Kan, Curtis, 2nd, Alan D, Eudailey, Joshua A, Fox, Christopher B, Tomai, Mark A, Phillips, Bonnie, Itell, Hannah L, Kunz, Erika, Hudgens, Michael, Cronin, Kenneth, Wiehe, Kevin, Alam, S Munir, Van Rompay, Koen K A, De Paris, Kristina, Permar, Sallie R, Moody, M Anthony, Fouda, Genevieve G
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 31.12.2021; Public Library of Science (PLoS)
• Subjects: Acquired immune deficiency syndrome; Adjuvants; Adjuvants, Immunologic - pharmacology; AIDS; AIDS vaccines; AIDS Vaccines - blood; AIDS Vaccines - immunology; Analysis; Animals; Antibodies; Antibody Formation - drug effects; Antibody Formation - immunology; Antigens; Avidity; B cells; B-cell receptor; Babies; Biology and life sciences; Care and treatment; Child; Complementarity Determining Regions; Demographic aspects; Diagnosis; env Gene Products, Human Immunodeficiency Virus - immunology; Epitopes; Epitopes - immunology; Frequency ranges; Health aspects; HIV; HIV infection; Human immunodeficiency virus; Humans; Immunization; Immunogenetics; Immunoglobulin Heavy Chains - metabolism; Immunoglobulins; Immunologic Memory - drug effects; Immunological memory; Immunology; Infants; Laboratory animals; Lymphocytes B; Macaca mulatta; Medicine; Medicine and health sciences; Memory cells; Monoclonal antibodies; Patient outcomes; Pediatrics; Plasma; Primates; Proteins; Receptors; Receptors, Antigen, B-Cell - metabolism; Research and Analysis Methods; Somatic Hypermutation, Immunoglobulin; Squalene; Toll-Like Receptors - agonists; Toll-Like Receptors - metabolism; Vaccines; Viral envelope proteins; United States; North Carolina; New York; California; United States > US; New York City New York

Different HIV vaccine regimens elicit distinct plasma antibody responses in both human and nonhuman primate models. Previous studies in human and non-human primate infants showed that adjuvants influenced the quality of plasma antibody responses induced by pediatric HIV envelope vaccine regimens. We...