Different adjuvanted pediatric HIV envelope vaccines induced distinct plasma antibody responses despite similar B cell receptor repertoires in infant rhesus macaques
Different HIV vaccine regimens elicit distinct plasma antibody responses in both human and nonhuman primate models. Previous studies in human and non-human primate infants showed that adjuvants influenced the quality of plasma antibody responses induced by pediatric HIV envelope vaccine regimens. We...
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Published in | PloS one Vol. 16; no. 12; p. e0256885 |
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Main Authors | , , , , , , , , , , , , , , , , , , , , , |
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Language | English |
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Public Library of Science
31.12.2021
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Abstract | Different HIV vaccine regimens elicit distinct plasma antibody responses in both human and nonhuman primate models. Previous studies in human and non-human primate infants showed that adjuvants influenced the quality of plasma antibody responses induced by pediatric HIV envelope vaccine regimens. We recently reported that use of the 3M052-SE adjuvant and longer intervals between vaccinations are associated with higher magnitude of antibody responses in infant rhesus macaques. However, the impact of different adjuvants in HIV vaccine regimens on the developing infant B cell receptor (BCR) repertoire has not been studied. This study evaluated whether pediatric HIV envelope vaccine regimens with different adjuvants induced distinct antigen-specific memory B cell repertoires and whether specific immunoglobulin (Ig) immunogenetic characteristics are associated with higher magnitude of plasma antibody responses in vaccinated infant rhesus macaques. We utilized archived preclinical pediatric HIV vaccine studies PBMCs and tissue samples from 19 infant rhesus macaques immunized either with (i) HIV Env protein with a squalene adjuvant, (ii) MVA-HIV and Env protein co-administered using a 3-week interval, (iii) MVA-HIV prime/ protein boost with an extended 6-week interval between immunizations, or (iv) with HIV Env administered with 3M-052-SE adjuvant. Frequencies of vaccine-elicited HIV Env-specific memory B cells from PBMCs and tissues were similar across vaccination groups (frequency range of 0.06-1.72%). There was no association between vaccine-elicited antigen-specific memory B cell frequencies and plasma antibody titer or avidity. Moreover, the epitope specificity and Ig immunogenetic features of vaccine-elicited monoclonal antibodies did not differ between the different vaccine regimens. These data suggest that pediatric HIV envelope vaccine candidates with different adjuvants that previously induced higher magnitude and quality of plasma antibody responses in infant rhesus macaques were not driven by distinct antigen-specific memory BCR repertoires. |
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AbstractList | Different HIV vaccine regimens elicit distinct plasma antibody responses in both human and nonhuman primate models. Previous studies in human and non-human primate infants showed that adjuvants influenced the quality of plasma antibody responses induced by pediatric HIV envelope vaccine regimens. We recently reported that use of the 3M052-SE adjuvant and longer intervals between vaccinations are associated with higher magnitude of antibody responses in infant rhesus macaques. However, the impact of different adjuvants in HIV vaccine regimens on the developing infant B cell receptor (BCR) repertoire has not been studied. This study evaluated whether pediatric HIV envelope vaccine regimens with different adjuvants induced distinct antigen-specific memory B cell repertoires and whether specific immunoglobulin (Ig) immunogenetic characteristics are associated with higher magnitude of plasma antibody responses in vaccinated infant rhesus macaques. We utilized archived preclinical pediatric HIV vaccine studies PBMCs and tissue samples from 19 infant rhesus macaques immunized either with (i) HIV Env protein with a squalene adjuvant, (ii) MVA-HIV and Env protein co-administered using a 3-week interval, (iii) MVA-HIV prime/ protein boost with an extended 6-week interval between immunizations, or (iv) with HIV Env administered with 3M-052-SE adjuvant. Frequencies of vaccine-elicited HIV Env-specific memory B cells from PBMCs and tissues were similar across vaccination groups (frequency range of 0.06–1.72%). There was no association between vaccine-elicited antigen-specific memory B cell frequencies and plasma antibody titer or avidity. Moreover, the epitope specificity and Ig immunogenetic features of vaccine-elicited monoclonal antibodies did not differ between the different vaccine regimens. These data suggest that pediatric HIV envelope vaccine candidates with different adjuvants that previously induced higher magnitude and quality of plasma antibody responses in infant rhesus macaques were not driven by distinct antigen-specific memory BCR repertoires. |
Audience | Academic |
Author | Berendam, Stella J Hudgens, Michael Itell, Hannah L Permar, Sallie R Luo, Kan Heimsath, Holly Li, Shuk Hang De Paris, Kristina Tomai, Mark A Van Rompay, Koen K A Cronin, Kenneth Fouda, Genevieve G Curtis, 2nd, Alan D Morgan-Asiedu, Papa K Alam, S Munir Phillips, Bonnie Moody, M Anthony Wiehe, Kevin Eudailey, Joshua A Mangan, Riley J Fox, Christopher B Kunz, Erika |
AuthorAffiliation | 2 Department of Microbiology and Immunology, Children’s Research Institute and Center for AIDS Research, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America 3 Department of Pediatrics, Weill Cornell College of Medicine, New York City, New York, United States of America 6 3M Center, 3 M Drug Delivery Systems, St. Paul, Minnesota, United States of America 4 Infectious Disease Research Institute (IDRI), Seattle, Washington State, United States of America 5 Department of Global Health, University of Washington, Seattle, Washington State, United States of America 7 Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America Stanford University School of Medicine, UNITED STATES 8 California National Primate Research Center, University of California at Davis, Davis, California, United States of America 1 Duke Human Vaccine Institute, Duke University Medical Center, Du |
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CitedBy_id | crossref_primary_10_1038_s41596_023_00930_8 |
Cites_doi | 10.1016/j.immuni.2020.12.018 10.1056/NEJMoa1113425 10.1086/319863 10.1086/314985 10.1097/00126334-200502010-00002 10.1056/NEJMoa0908492 10.1093/infdis/jiu444 10.1097/01.aids.0000237363.33994.45 10.1371/journal.pmed.1001608 10.7326/0003-4819-114-2-119 10.1128/JVI.01051-18 10.1016/j.cell.2019.04.012 10.1111/imm.12845 10.1038/cti.2016.42 10.3389/fimmu.2017.01407 10.4049/jimmunol.1600497 10.1016/j.vaccine.2017.09.054 10.1128/JVI.77.1.179-190.2003 10.1128/CVI.00231-17 10.1172/jci.insight.91020 10.1086/498163 10.12688/f1000research.2-103.v1 10.1016/j.immuni.2014.11.014 10.1097/QAD.0000000000000143 10.1016/j.cell.2016.05.055 10.1038/nm.3565 10.1016/S1473-3099(12)70088-9 10.4049/jimmunol.1800342 10.1038/nbt.3187 10.3851/IMP2437 10.1016/j.jviromet.2009.02.014 10.1097/QAI.0b013e31827f1c2d 10.1542/pir.35.7.268 10.1097/01.qai.0000435600.65845.31 10.4049/jimmunol.1901256 |
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Copyright | COPYRIGHT 2021 Public Library of Science 2021 Berendam et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2021 Berendam et al 2021 Berendam et al |
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References | ML Robb (pone.0256885.ref014) 2012; 12 L Lin (pone.0256885.ref017) 2015; 33 DC Johnson (pone.0256885.ref018) 2005; 192 GG Fouda (pone.0256885.ref022) 2015; 211 K Wiehe (pone.0256885.ref030) 2014; 41 V Vigdorovich (pone.0256885.ref039) 2016; 5 K Dai (pone.0256885.ref042) 2015; 6 AD Haas (pone.0256885.ref002) 2016; 63 BF Haynes (pone.0256885.ref015) 2012; 366 S Rerks-Ngarm (pone.0256885.ref013) 2009; 361 B Phillips (pone.0256885.ref025) 2017; 24 BC Holbrook (pone.0256885.ref035) 2018; 153 pone.0256885.ref016 L Tenthani (pone.0256885.ref003) 2014; 28 B Phillips (pone.0256885.ref026) 2018; 92 Y Gao (pone.0256885.ref009) 2018; 10 P Kaleebu (pone.0256885.ref020) 2014; 65 BC Holbrook (pone.0256885.ref037) 2016; 197 A Ramesh (pone.0256885.ref032) 2017; 8 TB Kepler (pone.0256885.ref031) 2013; 2 N Vazquez Bernat (pone.0256885.ref034) 2021; 54 EJ McFarland (pone.0256885.ref019) 2006; 20 HN Brochu (pone.0256885.ref040) 2020; 204 NIAID AIDS Vaccine Clinical Trials Network (pone.0256885.ref010) 1991; 114 KM Cirelli (pone.0256885.ref033) 2019; 177 CA Simonich (pone.0256885.ref038) 2016; 166 PF Wright (pone.0256885.ref011) 1999; 180 W Zhang (pone.0256885.ref041) 2019; 202 GK Siberry (pone.0256885.ref008) 2014; 35 AL Drake (pone.0256885.ref006) 2014; 11 RB Belshe (pone.0256885.ref012) 2001; 183 KK Van Rompay (pone.0256885.ref023) 2003; 77 pone.0256885.ref001 pone.0256885.ref005 L Goo (pone.0256885.ref043) 2014; 20 pone.0256885.ref007 KM Stadeli (pone.0256885.ref004) 2015; 18 KK Van Rompay (pone.0256885.ref024) 2005; 38 K Luo (pone.0256885.ref028) 2016; 1 HX Liao (pone.0256885.ref029) 2009; 158 K Kintu (pone.0256885.ref021) 2013; 63 DJ Dowling (pone.0256885.ref027) 2017; 2 BC Holbrook (pone.0256885.ref036) 2017; 35 |
References_xml | – volume: 54 start-page: 355 issue: 2 year: 2021 ident: pone.0256885.ref034 article-title: Rhesus and cynomolgus macaque immunoglobulin heavy-chain genotyping yields comprehensive databases of germline VDJ alleles publication-title: Immunity doi: 10.1016/j.immuni.2020.12.018 contributor: fullname: N Vazquez Bernat – volume: 366 start-page: 1275 issue: 14 year: 2012 ident: pone.0256885.ref015 article-title: Immune-correlates analysis of an HIV-1 vaccine efficacy trial publication-title: N Engl J Med doi: 10.1056/NEJMoa1113425 contributor: fullname: BF Haynes – volume: 183 start-page: 1343 issue: 9 year: 2001 ident: pone.0256885.ref012 article-title: Safety and immunogenicity of a canarypox-vectored human immunodeficiency virus Type 1 vaccine with or without gp120: a phase 2 study in higher- and lower-risk volunteers publication-title: J Infect Dis doi: 10.1086/319863 contributor: fullname: RB Belshe – volume: 63 start-page: 1227 issue: 9 year: 2016 ident: pone.0256885.ref002 article-title: Adherence to Antiretroviral Therapy During and After Pregnancy: Cohort Study on Women Receiving Care in Malawi’s Option B+ Program publication-title: Clin Infect Dis contributor: fullname: AD Haas – volume: 180 start-page: 1080 issue: 4 year: 1999 ident: pone.0256885.ref011 article-title: Immunization with envelope MN rgp120 vaccine in human immunodeficiency virus-infected pregnant women publication-title: J Infect Dis doi: 10.1086/314985 contributor: fullname: PF Wright – volume: 10 issue: 4 year: 2018 ident: pone.0256885.ref009 article-title: Advances in HIV-1 Vaccine Development publication-title: Viruses contributor: fullname: Y Gao – volume: 38 start-page: 124 issue: 2 year: 2005 ident: pone.0256885.ref024 article-title: Attenuated poxvirus-based simian immunodeficiency virus (SIV) vaccines given in infancy partially protect infant and juvenile macaques against repeated oral challenge with virulent SIV publication-title: J Acquir Immune Defic Syndr doi: 10.1097/00126334-200502010-00002 contributor: fullname: KK Van Rompay – volume: 361 start-page: 2209 issue: 23 year: 2009 ident: pone.0256885.ref013 article-title: Vaccination with ALVAC and AIDSVAX to prevent HIV-1 infection in Thailand publication-title: N Engl J Med doi: 10.1056/NEJMoa0908492 contributor: fullname: S Rerks-Ngarm – ident: pone.0256885.ref007 – ident: pone.0256885.ref005 – volume: 211 start-page: 508 issue: 4 year: 2015 ident: pone.0256885.ref022 article-title: Infant HIV type 1 gp120 vaccination elicits robust and durable anti-V1V2 immunoglobulin G responses and only rare envelope-specific immunoglobulin A responses publication-title: J Infect Dis doi: 10.1093/infdis/jiu444 contributor: fullname: GG Fouda – volume: 20 start-page: 1481 issue: 11 year: 2006 ident: pone.0256885.ref019 article-title: HIV-1 vaccine induced immune responses in newborns of HIV-1 infected mothers publication-title: AIDS doi: 10.1097/01.aids.0000237363.33994.45 contributor: fullname: EJ McFarland – volume: 11 year: 2014 ident: pone.0256885.ref006 article-title: Incident HIV during pregnancy and postpartum and risk of mother-to-child HIV transmission: a systematic review and meta-analysis publication-title: PloS Med doi: 10.1371/journal.pmed.1001608 contributor: fullname: AL Drake – volume: 114 start-page: 119 issue: 2 year: 1991 ident: pone.0256885.ref010 article-title: The safety and immunogenicity of a human immunodeficiency virus type 1 (HIV-1) recombinant gp160 candidate vaccine in humans publication-title: Ann Intern Med doi: 10.7326/0003-4819-114-2-119 contributor: fullname: NIAID AIDS Vaccine Clinical Trials Network – volume: 92 issue: 20 year: 2018 ident: pone.0256885.ref026 article-title: Adjuvant-Dependent Enhancement of HIV Env-Specific Antibody Responses in Infant Rhesus Macaques publication-title: J Virol doi: 10.1128/JVI.01051-18 contributor: fullname: B Phillips – volume: 177 start-page: 1153 issue: 5 year: 2019 ident: pone.0256885.ref033 article-title: Slow Delivery Immunization Enhances HIV Neutralizing Antibody and Germinal Center Responses via Modulation of Immunodominance publication-title: Cell doi: 10.1016/j.cell.2019.04.012 contributor: fullname: KM Cirelli – volume: 153 start-page: 357 issue: 3 year: 2018 ident: pone.0256885.ref035 article-title: An R848 adjuvanted influenza vaccine promotes early activation of B cells in the draining lymph nodes of non-human primate neonates publication-title: Immunology doi: 10.1111/imm.12845 contributor: fullname: BC Holbrook – volume: 5 start-page: e93 issue: 7 year: 2016 ident: pone.0256885.ref039 article-title: Repertoire comparison of the B-cell receptor-encoding loci in humans and rhesus macaques by next-generation sequencing publication-title: Clin Transl Immunology doi: 10.1038/cti.2016.42 contributor: fullname: V Vigdorovich – volume: 8 start-page: 1407 year: 2017 ident: pone.0256885.ref032 article-title: Structure and Diversity of the Rhesus Macaque Immunoglobulin Loci through Multiple De Novo Genome Assemblies publication-title: Front Immunol doi: 10.3389/fimmu.2017.01407 contributor: fullname: A Ramesh – ident: pone.0256885.ref016 – volume: 197 start-page: 555 issue: 2 year: 2016 ident: pone.0256885.ref037 article-title: A Novel R848-Conjugated Inactivated Influenza Virus Vaccine Is Efficacious and Safe in a Neonate Nonhuman Primate Model publication-title: J Immunol doi: 10.4049/jimmunol.1600497 contributor: fullname: BC Holbrook – ident: pone.0256885.ref001 – volume: 35 start-page: 6137 issue: 45 year: 2017 ident: pone.0256885.ref036 article-title: Adjuvanting an inactivated influenza vaccine with conjugated R848 improves the level of antibody present at 6months in a nonhuman primate neonate model publication-title: Vaccine doi: 10.1016/j.vaccine.2017.09.054 contributor: fullname: BC Holbrook – volume: 77 start-page: 179 issue: 1 year: 2003 ident: pone.0256885.ref023 article-title: Immunization of newborn rhesus macaques with simian immunodeficiency virus (SIV) vaccines prolongs survival after oral challenge with virulent SIVmac251 publication-title: J Virol doi: 10.1128/JVI.77.1.179-190.2003 contributor: fullname: KK Van Rompay – volume: 24 issue: 10 year: 2017 ident: pone.0256885.ref025 article-title: Impact of Poxvirus Vector Priming, Protein Coadministration, and Vaccine Intervals on HIV gp120 Vaccine-Elicited Antibody Magnitude and Function in Infant Macaques publication-title: Clin Vaccine Immunol doi: 10.1128/CVI.00231-17 contributor: fullname: B Phillips – volume: 2 start-page: e91020 issue: 6 year: 2017 ident: pone.0256885.ref027 article-title: TLR7/8 adjuvant overcomes newborn hyporesponsiveness to pneumococcal conjugate vaccine at birth publication-title: JCI Insight doi: 10.1172/jci.insight.91020 contributor: fullname: DJ Dowling – volume: 192 start-page: 2129 issue: 12 year: 2005 ident: pone.0256885.ref018 article-title: Safety and immunogenicity of an HIV-1 recombinant canarypox vaccine in newborns and infants of HIV-1-infected women publication-title: J Infect Dis doi: 10.1086/498163 contributor: fullname: DC Johnson – volume: 2 start-page: 103 year: 2013 ident: pone.0256885.ref031 article-title: Reconstructing a B-cell clonal lineage. I. Statistical inference of unobserved ancestors publication-title: F1000Res doi: 10.12688/f1000research.2-103.v1 contributor: fullname: TB Kepler – volume: 6 start-page: e01375 issue: 6 year: 2015 ident: pone.0256885.ref042 article-title: Rhesus Macaque B-Cell Responses to an HIV-1 Trimer Vaccine Revealed by Unbiased Longitudinal Repertoire Analysis publication-title: mBio contributor: fullname: K Dai – volume: 41 start-page: 909 issue: 6 year: 2014 ident: pone.0256885.ref030 article-title: Antibody light-chain-restricted recognition of the site of immune pressure in the RV144 HIV-1 vaccine trial is phylogenetically conserved publication-title: Immunity doi: 10.1016/j.immuni.2014.11.014 contributor: fullname: K Wiehe – volume: 28 start-page: 589 issue: 4 year: 2014 ident: pone.0256885.ref003 article-title: Retention in care under universal antiretroviral therapy for HIV-infected pregnant and breastfeeding women (’Option B+’) in Malawi publication-title: AIDS doi: 10.1097/QAD.0000000000000143 contributor: fullname: L Tenthani – volume: 166 start-page: 77 issue: 1 year: 2016 ident: pone.0256885.ref038 article-title: HIV-1 Neutralizing Antibodies with Limited Hypermutation from an Infant publication-title: Cell doi: 10.1016/j.cell.2016.05.055 contributor: fullname: CA Simonich – volume: 20 start-page: 655 issue: 6 year: 2014 ident: pone.0256885.ref043 article-title: Early development of broadly neutralizing antibodies in HIV-1-infected infants publication-title: Nat Med doi: 10.1038/nm.3565 contributor: fullname: L Goo – volume: 12 start-page: 531 issue: 7 year: 2012 ident: pone.0256885.ref014 article-title: Risk behaviour and time as covariates for efficacy of the HIV vaccine regimen ALVAC-HIV (vCP1521) and AIDSVAX B/E: a post-hoc analysis of the Thai phase 3 efficacy trial RV 144 publication-title: Lancet Infect Dis doi: 10.1016/S1473-3099(12)70088-9 contributor: fullname: ML Robb – volume: 1 start-page: e88522 issue: 20 year: 2016 ident: pone.0256885.ref028 article-title: Tissue memory B cell repertoire analysis after ALVAC/AIDSVAX B/E gp120 immunization of rhesus macaques publication-title: JCI Insight contributor: fullname: K Luo – volume: 202 start-page: 1612 issue: 5 year: 2019 ident: pone.0256885.ref041 article-title: Identification of Variable and Joining Germline Genes and Alleles for Rhesus Macaque from B Cell Receptor Repertoires publication-title: J Immunol doi: 10.4049/jimmunol.1800342 contributor: fullname: W Zhang – volume: 33 start-page: 610 issue: 6 year: 2015 ident: pone.0256885.ref017 article-title: COMPASS identifies T-cell subsets correlated with clinical outcomes publication-title: Nat Biotechnol doi: 10.1038/nbt.3187 contributor: fullname: L Lin – volume: 18 start-page: 115 issue: 1 year: 2015 ident: pone.0256885.ref004 article-title: Rates of emergence of HIV drug resistance in resource-limited settings: a systematic review publication-title: Antivir Ther doi: 10.3851/IMP2437 contributor: fullname: KM Stadeli – volume: 158 start-page: 171 issue: 1–2 year: 2009 ident: pone.0256885.ref029 article-title: High-throughput isolation of immunoglobulin genes from single human B cells and expression as monoclonal antibodies publication-title: J Virol Methods doi: 10.1016/j.jviromet.2009.02.014 contributor: fullname: HX Liao – volume: 63 start-page: 1 issue: 1 year: 2013 ident: pone.0256885.ref021 article-title: Feasibility and safety of ALVAC-HIV vCP1521 vaccine in HIV-exposed infants in Uganda: results from the first HIV vaccine trial in infants in Africa publication-title: J Acquir Immune Defic Syndr doi: 10.1097/QAI.0b013e31827f1c2d contributor: fullname: K Kintu – volume: 35 start-page: 268 issue: 7 year: 2014 ident: pone.0256885.ref008 article-title: Preventing and managing HIV infection in infants, children, and adolescents in the United States publication-title: Pediatr Rev doi: 10.1542/pir.35.7.268 contributor: fullname: GK Siberry – volume: 65 start-page: 268 issue: 3 year: 2014 ident: pone.0256885.ref020 article-title: Immunogenicity of ALVAC-HIV vCP1521 in infants of HIV-1-infected women in Uganda (HPTN 027): the first pediatric HIV vaccine trial in Africa publication-title: J Acquir Immune Defic Syndr doi: 10.1097/01.qai.0000435600.65845.31 contributor: fullname: P Kaleebu – volume: 204 start-page: 3434 issue: 12 year: 2020 ident: pone.0256885.ref040 article-title: Systematic Profiling of Full-Length Ig and TCR Repertoire Diversity in Rhesus Macaque through Long Read Transcriptome Sequencing publication-title: J Immunol doi: 10.4049/jimmunol.1901256 contributor: fullname: HN Brochu |
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SubjectTerms | Acquired immune deficiency syndrome Adjuvants Adjuvants, Immunologic - pharmacology AIDS AIDS vaccines AIDS Vaccines - blood AIDS Vaccines - immunology Analysis Animals Antibodies Antibody Formation - drug effects Antibody Formation - immunology Antigens Avidity B cells B-cell receptor Babies Biology and life sciences Care and treatment Child Complementarity Determining Regions Demographic aspects Diagnosis env Gene Products, Human Immunodeficiency Virus - immunology Epitopes Epitopes - immunology Frequency ranges Health aspects HIV HIV infection Human immunodeficiency virus Humans Immunization Immunogenetics Immunoglobulin Heavy Chains - metabolism Immunoglobulins Immunologic Memory - drug effects Immunological memory Immunology Infants Laboratory animals Lymphocytes B Macaca mulatta Medicine Medicine and health sciences Memory cells Monoclonal antibodies Patient outcomes Pediatrics Plasma Primates Proteins Receptors Receptors, Antigen, B-Cell - metabolism Research and Analysis Methods Somatic Hypermutation, Immunoglobulin Squalene Toll-Like Receptors - agonists Toll-Like Receptors - metabolism Vaccines Viral envelope proteins |
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Title | Different adjuvanted pediatric HIV envelope vaccines induced distinct plasma antibody responses despite similar B cell receptor repertoires in infant rhesus macaques |
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