Morphine Modulates Adult Neurogenesis and Contextual Memory by Impeding the Maturation of Neural Progenitors

• Published in: PloS one Vol. 11; no. 4; p. e0153628
• Main Authors: Zhang, Yue, Xu, Chi, Zheng, Hui, Loh, Horace H., Law, Ping-Yee
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 14.04.2016; Public Library of Science (PLoS)
• Subjects: Addictions; Analgesics, Opioid - pharmacology; Animals; Animals, Newborn; Apoptosis; Beta2 protein; Biology and Life Sciences; Biomarkers; Cell Differentiation - drug effects; Cocaine; Comparative analysis; Conditioning; Conditioning, Operant - drug effects; Differentiation; Doublecortin protein; Drug abuse; Genetic aspects; Green Fluorescent Proteins - genetics; Green Fluorescent Proteins - metabolism; Heroin; Hippocampus - cytology; Hippocampus - metabolism; Immunohistochemistry; Localization; Male; Medicine and Health Sciences; Memory - drug effects; Methamphetamine; Mice; Mice, Inbred C57BL; Mice, Transgenic; Morphine; Morphine - pharmacology; Narcotics; Nestin; Neural stem cells; Neural Stem Cells - drug effects; Neural Stem Cells - metabolism; Neurogenesis; Neurogenesis - drug effects; Neurons; Neurons - drug effects; Neurons - metabolism; Opiates; Opioids; Pharmacology; Physiological aspects; Place preference conditioning; Proopiomelanocortin; Research and Analysis Methods; Rodents; Spatial Learning - drug effects; Stem cell transplantation; Stem cells; Training; Tubulin; United States; China; United States > US; Minnesota

The regulation of adult neurogenesis by opiates has been implicated in modulating different addiction cycles. At which neurogenesis stage opiates exert their action remains unresolved. We attempt to define the temporal window of morphine's inhibition effect on adult neurogenesis by using the PO...