Unique Microstructural Changes in the Brain Associated with Urological Chronic Pelvic Pain Syndrome (UCPPS) Revealed by Diffusion Tensor MRI, Super-Resolution Track Density Imaging, and Statistical Parameter Mapping: A MAPP Network Neuroimaging Study

• Published in: PloS one Vol. 10; no. 10; p. e0140250
• Main Authors: Woodworth, Davis, Mayer, Emeran, Leu, Kevin, Ashe-McNalley, Cody, Naliboff, Bruce D., Labus, Jennifer S., Tillisch, Kirsten, Kutch, Jason J., Farmer, Melissa A., Apkarian, A. Vania, Johnson, Kevin A., Mackey, Sean C., Ness, Timothy J., Landis, J. Richard, Deutsch, Georg, Harris, Richard E., Clauw, Daniel J., Mullins, Chris, Ellingson, Benjamin M.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 13.10.2015; Public Library of Science (PLoS)
• Subjects: Adult; Anisotropy; Basal ganglia; Bladder; Brain; Brain - pathology; Brain mapping; Care and treatment; Case-Control Studies; Chronic pain; Chronic Pain - pathology; Clustering; Comparative analysis; Cortex; Cystitis; Density; Development and progression; Diagnosis; Diffusion Magnetic Resonance Imaging; Disorders; Female; Ganglia; Graphical representations; Health aspects; Humans; Image resolution; Intestine; Irritable bowel syndrome; Irritable Bowel Syndrome - pathology; Magnetic resonance imaging; Male; Medical imaging; Modulation; Neuroimaging; Neurology; Pain; Pain perception; Patient outcomes; Patients; Pelvic Pain - pathology; Perception; Population (statistical); Population studies; Prostatitis; Sensory integration; Sex Characteristics; Thalamus; United States; Los Angeles California; Palo Alto California; United States > US; Illinois; California; Chicago Illinois; Alabama; Ann Arbor Michigan; Michigan

Studies have suggested chronic pain syndromes are associated with neural reorganization in specific regions associated with perception, processing, and integration of pain. Urological chronic pelvic pain syndrome (UCPPS) represents a collection of pain syndromes characterized by pelvic pain, namely...