O-antigen protects gram-negative bacteria from histone killing
Beyond their traditional role of wrapping DNA, histones display antibacterial activity to Gram-negative and -positive bacteria. To identify bacterial components that allow survival to a histone challenge, we selected resistant bacteria from homologous Escherichia coli libraries that harbor plasmids...
Saved in:
| Published in | PloS one Vol. 8; no. 8; p. e71097 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Public Library of Science
08.08.2013
Public Library of Science (PLoS) |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Beyond their traditional role of wrapping DNA, histones display antibacterial activity to Gram-negative and -positive bacteria. To identify bacterial components that allow survival to a histone challenge, we selected resistant bacteria from homologous Escherichia coli libraries that harbor plasmids carrying pieces of the chromosome in different sizes. We identified genes required for exopolysaccharide production and for the synthesis of the polysaccharide domain of the lipopolysaccharide, called O-antigen. Indeed, O-antigen and exopolysaccharide conferred further resistance to histones. Notably, O-antigen also conferred resistance to histones in the pathogens Shigella flexneri and Klebsiella pneumoniae. |
|---|---|
| AbstractList | Beyond their traditional role of wrapping DNA, histones display antibacterial activity to Gram-negative and -positive bacteria. To identify bacterial components that allow survival to a histone challenge, we selected resistant bacteria from homologous
Escherichia coli
libraries that harbor plasmids carrying pieces of the chromosome in different sizes. We identified genes required for exopolysaccharide production and for the synthesis of the polysaccharide domain of the lipopolysaccharide, called O-antigen. Indeed, O-antigen and exopolysaccharide conferred further resistance to histones. Notably, O-antigen also conferred resistance to histones in the pathogens
Shigella flexneri
and
Klebsiella pneumoniae
. Beyond their traditional role of wrapping DNA, histones display antibacterial activity to Gram-negative and -positive bacteria. To identify bacterial components that allow survival to a histone challenge, we selected resistant bacteria from homologous Escherichia coli libraries that harbor plasmids carrying pieces of the chromosome in different sizes. We identified genes required for exopolysaccharide production and for the synthesis of the polysaccharide domain of the lipopolysaccharide, called O-antigen. Indeed, O-antigen and exopolysaccharide conferred further resistance to histones. Notably, O-antigen also conferred resistance to histones in the pathogens Shigella flexneri and Klebsiella pneumoniae. |
| Audience | Academic |
| Author | Chaput, Catherine Gill, Ryan T Zychlinsky, Arturo Spindler, Eileen |
| AuthorAffiliation | 2 Department of Chemical and Biological Engineering, University of Colorado, Boulder, Colorado, United States of America 1 Department of Cellular Microbiology, Max-Planck Institute for Infection Biology, Berlin, Germany The Scripps Research Institute and Sorrento Therapeutics, Inc., United States of America |
| AuthorAffiliation_xml | – name: 1 Department of Cellular Microbiology, Max-Planck Institute for Infection Biology, Berlin, Germany – name: 2 Department of Chemical and Biological Engineering, University of Colorado, Boulder, Colorado, United States of America – name: The Scripps Research Institute and Sorrento Therapeutics, Inc., United States of America |
| Author_xml | – sequence: 1 givenname: Catherine surname: Chaput fullname: Chaput, Catherine email: catherine.chaput@charite.de organization: Department of Cellular Microbiology, Max-Planck Institute for Infection Biology, Berlin, Germany. catherine.chaput@charite.de – sequence: 2 givenname: Eileen surname: Spindler fullname: Spindler, Eileen – sequence: 3 givenname: Ryan T surname: Gill fullname: Gill, Ryan T – sequence: 4 givenname: Arturo surname: Zychlinsky fullname: Zychlinsky, Arturo |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/23951089$$D View this record in MEDLINE/PubMed |
| BookMark | eNqNkttq3DAQhk1JaQ7tG5TWUCjthbc62ZZuAiGk7UJgoadbIcuyV1tZ2khyaN8-2qwT1iUXRRcSo2_-XzOa0-zIOquy7DUEC4hr-GnjRm-FWWxTeAFADQGrn2UnkGFUVAjgo4PzcXYawgaAEtOqepEdI8xKCCg7yc5XhbBR98rmW--ikjHkvRdDYVUvor5VeSNkVF6LvPNuyNc6xGSY_9bGaNu_zJ53wgT1atrPsp-fr35cfi2uV1-WlxfXhawYigVWpaAlBbgsSatY29RAsApR3LG6FGUNZINY1YlaSMRY06muI5JKShFqKlkpfJa93etujQt8Kj1wSDBAJcEVSMRyT7RObPjW60H4v9wJze8Dzvdc-KilURyQBrbJpIRtRWiNWANphzEhgkKkGEpa55Pb2AyqlcpGL8xMdH5j9Zr37pbjGtPyXuDDJODdzahC5IMOUhkjrHLj7t2oArBGBCf03T_o09VNVC9SAdp2LvnKnSi_IDXFqQpCE7V4gkqrVYOW6ds6neKzhI-zhMRE9Sf2YgyBL79_-3929WvOvj9g10qYuA7OjFE7G-Yg2YPSuxC86h6bDAHfjflDN_huzPk05intzeEHPSY9zDW-A_9X-D4 |
| CitedBy_id | crossref_primary_10_1128_spectrum_02400_22 crossref_primary_10_1111_jcmm_13797 crossref_primary_10_1099_mic_0_000827 crossref_primary_10_3389_fimmu_2014_00378 crossref_primary_10_1016_j_dci_2022_104529 crossref_primary_10_1371_journal_pgen_1010996 crossref_primary_10_1021_acschembio_1c00341 crossref_primary_10_1038_srep43039 crossref_primary_10_1016_j_clinbiochem_2021_04_019 crossref_primary_10_1126_scisignal_aao1716 crossref_primary_10_1128_aem_02203_23 crossref_primary_10_1186_s12995_020_00282_z crossref_primary_10_3390_microorganisms12071259 crossref_primary_10_1074_jbc_RA118_005707 |
| Cites_doi | 10.1016/0022-1759(90)90018-Q 10.1038/nmeth946 10.1128/AAC.00428-09 10.1038/nm1565 10.1126/science.1108472 10.1074/jbc.M611034200 10.1128/IAI.35.3.852-860.1982 10.1016/S0145-305X(03)00120-4 10.1038/nm.2053 10.1128/jb.178.16.4885-4893.1996 10.1128/IAI.57.2.546-552.1989 10.1016/j.drup.2010.05.002 10.1016/S0014-5793(98)01238-1 10.1084/jem.193.9.1067 10.1074/jbc.274.13.8405 10.1111/j.1574-6968.2002.tb11000.x 10.1021/bi0268394 10.1007/PL00000914 10.1016/0003-2697(82)90673-X 10.1006/bbrc.1996.0071 10.1128/AAC.01053-10 10.1074/mcp.M500143-MCP200 10.1016/S0021-9258(18)57178-7 10.1006/bbrc.1996.1814 10.1016/S0966-842X(02)02333-8 10.1128/IAI.70.5.2583-2590.2002 10.1084/jem.108.6.925 10.1128/IAI.72.12.7107-7114.2004 10.1039/c1np00022e 10.1046/j.1365-2958.2000.01823.x 10.1016/j.imlet.2008.05.003 10.1006/bbrc.1998.8159 10.1006/bbrc.2001.5020 |
| ContentType | Journal Article |
| Copyright | COPYRIGHT 2013 Public Library of Science 2013 Chaput et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2013 Chaput et al 2013 Chaput et al |
| Copyright_xml | – notice: COPYRIGHT 2013 Public Library of Science – notice: 2013 Chaput et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: 2013 Chaput et al 2013 Chaput et al |
| DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION IOV ISR 3V. 7QG 7QL 7QO 7RV 7SN 7SS 7T5 7TG 7TM 7U9 7X2 7X7 7XB 88E 8AO 8C1 8FD 8FE 8FG 8FH 8FI 8FJ 8FK ABJCF ABUWG AFKRA ARAPS ATCPS AZQEC BBNVY BENPR BGLVJ BHPHI C1K CCPQU D1I DWQXO FR3 FYUFA GHDGH GNUQQ H94 HCIFZ K9. KB. KB0 KL. L6V LK8 M0K M0S M1P M7N M7P M7S NAPCQ P5Z P62 P64 PATMY PDBOC PIMPY PQEST PQQKQ PQUKI PRINS PTHSS PYCSY RC3 7X8 5PM DOA |
| DOI | 10.1371/journal.pone.0071097 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef Gale_Opposing Viewpoints In Context Gale in Context: Science ProQuest Central (Corporate) Animal Behavior Abstracts Bacteriology Abstracts (Microbiology B) Biotechnology Research Abstracts ProQuest Nursing and Allied Health Journals Ecology Abstracts Entomology Abstracts (Full archive) Immunology Abstracts Meteorological & Geoastrophysical Abstracts Nucleic Acids Abstracts Virology and AIDS Abstracts Agricultural Science Collection ProQuest_Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest Pharma Collection ProQuest Public Health Database Technology Research Database ProQuest SciTech Collection ProQuest Technology Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) Materials Science & Engineering Collection ProQuest Central (Alumni) ProQuest Central Advanced Technologies & Aerospace Collection ProQuest Agriculture & Environmental Science Database ProQuest Central Essentials Biological Science Collection ProQuest Central Technology Collection ProQuest Natural Science Collection Environmental Sciences and Pollution Management ProQuest One Community College ProQuest Materials Science Collection ProQuest Central Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student AIDS and Cancer Research Abstracts SciTech Premium Collection (Proquest) (PQ_SDU_P3) ProQuest Health & Medical Complete (Alumni) ProQuest Materials Science Database Nursing & Allied Health Database (Alumni Edition) Meteorological & Geoastrophysical Abstracts - Academic ProQuest Engineering Collection Biological Sciences Agriculture Science Database Health & Medical Collection (Alumni Edition) PML(ProQuest Medical Library) Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Database ProQuest Engineering Database Nursing & Allied Health Premium ProQuest Advanced Technologies & Aerospace Database ProQuest Advanced Technologies & Aerospace Collection Biotechnology and BioEngineering Abstracts Environmental Science Database Materials Science Collection ProQuest - Publicly Available Content Database ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China Engineering Collection Environmental Science Collection Genetics Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) Directory of Open Access Journals |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef Agricultural Science Database Publicly Available Content Database ProQuest Central Student ProQuest Advanced Technologies & Aerospace Collection ProQuest Central Essentials Nucleic Acids Abstracts SciTech Premium Collection ProQuest Central China Environmental Sciences and Pollution Management Health Research Premium Collection Meteorological & Geoastrophysical Abstracts Natural Science Collection Biological Science Collection ProQuest Medical Library (Alumni) Engineering Collection Advanced Technologies & Aerospace Collection Engineering Database Virology and AIDS Abstracts ProQuest Biological Science Collection ProQuest One Academic Eastern Edition Agricultural Science Collection ProQuest Hospital Collection ProQuest Technology Collection Health Research Premium Collection (Alumni) Biological Science Database Ecology Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts Environmental Science Collection Entomology Abstracts Nursing & Allied Health Premium ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Environmental Science Database ProQuest Nursing & Allied Health Source (Alumni) Engineering Research Database ProQuest One Academic Meteorological & Geoastrophysical Abstracts - Academic Technology Collection Technology Research Database Materials Science Collection ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Central Genetics Abstracts ProQuest Engineering Collection Biotechnology Research Abstracts Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) Agricultural & Environmental Science Collection AIDS and Cancer Research Abstracts Materials Science Database ProQuest Materials Science Collection ProQuest Public Health ProQuest Nursing & Allied Health Source ProQuest SciTech Collection Advanced Technologies & Aerospace Database ProQuest Medical Library Animal Behavior Abstracts Materials Science & Engineering Collection Immunology Abstracts ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE Agricultural Science Database |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 4 dbid: 8FG name: ProQuest Technology Collection url: https://search.proquest.com/technologycollection1 sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Sciences (General) Biology |
| DocumentTitleAlternate | O-Antigen Protects Bacteria from Histone Killing |
| EISSN | 1932-6203 |
| Editor | Kaufmann, Gunnar F. |
| Editor_xml | – sequence: 1 givenname: Gunnar F. surname: Kaufmann fullname: Kaufmann, Gunnar F. |
| EndPage | e71097 |
| ExternalDocumentID | 1430254360 oai_doaj_org_article_04b1dbfe51d648729b18f3344a812e92 3063283141 A478387248 10_1371_journal_pone_0071097 23951089 |
| Genre | Journal Article |
| GeographicLocations | United States--US Colorado |
| GeographicLocations_xml | – name: Colorado – name: United States--US |
| GroupedDBID | --- 123 29O 2WC 3V. 53G 5VS 7RV 7X2 7X7 7XC 88E 8AO 8C1 8CJ 8FE 8FG 8FH 8FI 8FJ A8Z AAFWJ ABDBF ABIVO ABJCF ABUWG ACGFO ACIHN ACIWK ACPRK ADBBV ADRAZ AEAQA AENEX AFKRA AFRAH AHMBA ALIPV ALMA_UNASSIGNED_HOLDINGS AOIJS APEBS ARAPS ATCPS BAWUL BBNVY BBORY BCNDV BENPR BGLVJ BHPHI BKEYQ BPHCQ BVXVI BWKFM CCPQU CGR CS3 CUY CVF D1I D1J D1K DIK DU5 E3Z EAP EAS EBD ECM EIF EMOBN ESTFP ESX EX3 F5P FPL FYUFA GROUPED_DOAJ GX1 HCIFZ HH5 HMCUK HYE IAO IEA IHR IHW INH INR IOV IPNFZ IPY ISE ISR ITC K6- KB. KQ8 L6V LK5 LK8 M0K M1P M48 M7P M7R M7S M~E NAPCQ NPM O5R O5S OK1 P2P P62 PATMY PDBOC PIMPY PQQKQ PROAC PSQYO PTHSS PV9 PYCSY RIG RNS RPM RZL SV3 TR2 UKHRP WOQ WOW ~02 ~KM AAYXX AFPKN CITATION 7QG 7QL 7QO 7SN 7SS 7T5 7TG 7TM 7U9 7XB 8FD 8FK AZQEC C1K DWQXO FR3 GNUQQ H94 K9. KL. M7N P64 PQEST PQUKI PRINS RC3 7X8 5PM - 02 AAPBV ABPTK ADACO BBAFP KM |
| ID | FETCH-LOGICAL-c692t-3e5a85803554de9db70a96283f975a570cb296fa7ac299bfeff4c8c8822b6c6e3 |
| IEDL.DBID | RPM |
| ISSN | 1932-6203 |
| IngestDate | Sun Dec 05 00:11:31 EST 2021 Tue Oct 22 15:13:09 EDT 2024 Tue Sep 17 21:13:32 EDT 2024 Fri Oct 25 02:56:01 EDT 2024 Thu Oct 10 16:35:15 EDT 2024 Thu Feb 22 23:46:15 EST 2024 Tue Nov 12 23:27:15 EST 2024 Thu Aug 01 20:12:39 EDT 2024 Thu Aug 01 20:10:38 EDT 2024 Tue Aug 20 22:10:59 EDT 2024 Fri Aug 23 01:19:18 EDT 2024 Tue Oct 15 23:48:45 EDT 2024 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 8 |
| Language | English |
| License | This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. Creative Commons Attribution License |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c692t-3e5a85803554de9db70a96283f975a570cb296fa7ac299bfeff4c8c8822b6c6e3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Current address: Department of Infectious Diseases and Pulmonary Medicine, Charité University Hospital, Berlin, Germany Competing Interests: The authors have declared that no competing interests exist. Conceived and designed the experiments: CC RTG AZ. Performed the experiments: CC ES. Analyzed the data: CC. Contributed reagents/materials/analysis tools: CC ES RTG. Wrote the paper: CC. Current address: Opxbio, Boulder, Colorado, United States of America |
| OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3738592/ |
| PMID | 23951089 |
| PQID | 1430254360 |
| PQPubID | 1436336 |
| PageCount | e71097 |
| ParticipantIDs | plos_journals_1430254360 doaj_primary_oai_doaj_org_article_04b1dbfe51d648729b18f3344a812e92 pubmedcentral_primary_oai_pubmedcentral_nih_gov_3738592 proquest_miscellaneous_1426017243 proquest_journals_1430254360 gale_infotracmisc_A478387248 gale_infotracacademiconefile_A478387248 gale_incontextgauss_ISR_A478387248 gale_incontextgauss_IOV_A478387248 gale_healthsolutions_A478387248 crossref_primary_10_1371_journal_pone_0071097 pubmed_primary_23951089 |
| PublicationCentury | 2000 |
| PublicationDate | 2013-08-08 |
| PublicationDateYYYYMMDD | 2013-08-08 |
| PublicationDate_xml | – month: 08 year: 2013 text: 2013-08-08 day: 08 |
| PublicationDecade | 2010 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States – name: San Francisco – name: San Francisco, USA |
| PublicationTitle | PloS one |
| PublicationTitleAlternate | PLoS One |
| PublicationYear | 2013 |
| Publisher | Public Library of Science Public Library of Science (PLoS) |
| Publisher_xml | – name: Public Library of Science – name: Public Library of Science (PLoS) |
| References | 12969798 - Dev Comp Immunol. 2004 Feb;28(2):127-38 21617811 - Nat Prod Rep. 2011 Aug;28(8):1350-8 16450883 - Curr Issues Mol Biol. 2006 Jan;8(1):11-26 11814654 - FEMS Microbiol Lett. 2002 Jan 10;206(2):143-9 19855397 - Nat Med. 2009 Nov;15(11):1318-21 11497243 - Cell Mol Life Sci. 2001 Jun;58(7):978-89 12667084 - Biochemistry. 2003 Apr 8;42(13):3929-38 20843473 - Drug Resist Updat. 2010 Aug-Oct;13(4-5):132-8 2106001 - J Immunol Methods. 1990 Jan 24;126(1):109-17 21282431 - Antimicrob Agents Chemother. 2011 Apr;55(4):1706-16 15731456 - Science. 2005 Feb 25;307(5713):1313-7 19596877 - Antimicrob Agents Chemother. 2009 Oct;53(10):4200-10 8954908 - Biochem Biophys Res Commun. 1996 Dec 13;229(2):381-7 8759852 - J Bacteriol. 1996 Aug;178(16):4885-93 17099705 - Nat Methods. 2007 Jan;4(1):87-93 11396934 - Biochem Biophys Res Commun. 2001 Jun 15;284(3):549-55 2643575 - Infect Immun. 1989 Feb;57(2):546-52 15985654 - Mol Cell Proteomics. 2005 Oct;4(10):1503-21 6279518 - Infect Immun. 1982 Mar;35(3):852-60 15557634 - Infect Immun. 2004 Dec;72(12):7107-14 6176137 - Anal Biochem. 1982 Jan 1;119(1):115-9 13598820 - J Exp Med. 1958 Dec 1;108(6):925-44 11342591 - J Exp Med. 2001 May 7;193(9):1067-76 11953399 - Infect Immun. 2002 May;70(5):2583-90 10085071 - J Biol Chem. 1999 Mar 26;274(13):8405-10 17384648 - Nat Med. 2007 Apr;13(4):463-9 10760152 - Mol Microbiol. 2000 Mar;35(6):1530-9 17227761 - J Biol Chem. 2007 Mar 16;282(11):7790-8 10975843 - J Immunol. 2000 Sep 15;165(6):3268-74 8573171 - Biochem Biophys Res Commun. 1996 Jan 5;218(1):408-13 11912025 - Trends Microbiol. 2002 Apr;10(4):179-86 16936831 - Biochem Cell Biol. 2006 Aug;84(4):589-604 18573543 - Immunol Lett. 2008 Aug 15;119(1-2):4-11 9514864 - Biochem Biophys Res Commun. 1998 Mar 6;244(1):253-7 18880756 - J Biol Chem. 1948 Sep;175(2):595-603 9824303 - FEBS Lett. 1998 Oct 23;437(3):258-62 HS Kim (ref13) 2000; 165 NJ Edwards (ref18) 2000; 35 Z Dische (ref23) 1948; 175 A Peschel (ref26) 2001; 193 IY Park (ref9) 1998; 437 LA Augusto (ref35) 2003; 42 MH Parseghian (ref10) 2006; 84 M Li (ref27) 2009; 53 G Stevenson (ref22) 1996; 178 ME Falagas (ref34) 2010; 13 CB Park (ref8) 1996; 218 RC Richards (ref11) 2001; 284 G Lominadze (ref12) 2005; 4 JM Fernandes (ref4) 2004; 28 TC Meredith (ref21) 2007; 282 M Wilmes (ref32) 2011; 28 CM Tsai (ref20) 1982; 119 JG Hirsch (ref5) 1958; 108 ref28 RE Hancock (ref31) 2002; 206 MA Campos (ref30) 2004; 72 CB Park (ref7) 1998; 244 PJ Sansonetti (ref37) 1982; 35 HS Kim (ref6) 1996; 229 MD Lynch (ref17) 2007; 4 V Nizet (ref33) 2006; 8 X Nassif (ref36) 1989; 57 MA Holzl (ref1) 2008; 119 A Peschel (ref25) 1999; 274 A Peschel (ref2) 2002; 10 SR Clark (ref14) 2007; 13 EC Spindler (ref29) 2011; 55 NP West (ref24) 2005; 307 J Xu (ref15) 2009; 15 AJ Lesse (ref19) 1990; 126 G Cortes (ref16) 2002; 70 D Yang (ref3) 2001; 58 |
| References_xml | – volume: 126 start-page: 109 year: 1990 ident: ref19 article-title: Increased resolution of lipopolysaccharides and lipooligosaccharides utilizing tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis publication-title: J Immunol Methods doi: 10.1016/0022-1759(90)90018-Q contributor: fullname: AJ Lesse – volume: 4 start-page: 87 year: 2007 ident: ref17 article-title: SCALEs: multiscale analysis of library enrichment publication-title: Nat Methods doi: 10.1038/nmeth946 contributor: fullname: MD Lynch – volume: 53 start-page: 4200 year: 2009 ident: ref27 article-title: Staphylococcus aureus mutant screen reveals interaction of the human antimicrobial peptide dermcidin with membrane phospholipids publication-title: Antimicrob Agents Chemother doi: 10.1128/AAC.00428-09 contributor: fullname: M Li – volume: 13 start-page: 463 year: 2007 ident: ref14 article-title: Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood publication-title: Nat Med doi: 10.1038/nm1565 contributor: fullname: SR Clark – volume: 307 start-page: 1313 year: 2005 ident: ref24 article-title: Optimization of virulence functions through glucosylation of Shigella LPS publication-title: Science doi: 10.1126/science.1108472 contributor: fullname: NP West – volume: 282 start-page: 7790 year: 2007 ident: ref21 article-title: Modification of lipopolysaccharide with colanic acid (M-antigen) repeats in Escherichia coli publication-title: J Biol Chem doi: 10.1074/jbc.M611034200 contributor: fullname: TC Meredith – volume: 35 start-page: 852 year: 1982 ident: ref37 article-title: Involvement of a plasmid in the invasive ability of Shigella flexneri publication-title: Infect Immun doi: 10.1128/IAI.35.3.852-860.1982 contributor: fullname: PJ Sansonetti – volume: 28 start-page: 127 year: 2004 ident: ref4 article-title: Isolation and characterisation of oncorhyncin II, a histone H1-derived antimicrobial peptide from skin secretions of rainbow trout, Oncorhynchus mykiss publication-title: Dev Comp Immunol doi: 10.1016/S0145-305X(03)00120-4 contributor: fullname: JM Fernandes – volume: 15 start-page: 1318 year: 2009 ident: ref15 article-title: Extracellular histones are major mediators of death in sepsis publication-title: Nat Med doi: 10.1038/nm.2053 contributor: fullname: J Xu – volume: 178 start-page: 4885 year: 1996 ident: ref22 article-title: Organization of the Escherichia coli K-12 gene cluster responsible for production of the extracellular polysaccharide colanic acid publication-title: J Bacteriol doi: 10.1128/jb.178.16.4885-4893.1996 contributor: fullname: G Stevenson – volume: 8 start-page: 11 year: 2006 ident: ref33 article-title: Antimicrobial peptide resistance mechanisms of human bacterial pathogens publication-title: Curr Issues Mol Biol contributor: fullname: V Nizet – volume: 57 start-page: 546 year: 1989 ident: ref36 article-title: Mucoid phenotype of Klebsiella pneumoniae is a plasmid-encoded virulence factor publication-title: Infect Immun doi: 10.1128/IAI.57.2.546-552.1989 contributor: fullname: X Nassif – volume: 13 start-page: 132 year: 2010 ident: ref34 article-title: Resistance to polymyxins: Mechanisms, frequency and treatment options publication-title: Drug Resist Updat doi: 10.1016/j.drup.2010.05.002 contributor: fullname: ME Falagas – volume: 437 start-page: 258 year: 1998 ident: ref9 article-title: Parasin I, an antimicrobial peptide derived from histone H2A in the catfish, Parasilurus asotus publication-title: FEBS Lett doi: 10.1016/S0014-5793(98)01238-1 contributor: fullname: IY Park – volume: 193 start-page: 1067 year: 2001 ident: ref26 article-title: Staphylococcus aureus resistance to human defensins and evasion of neutrophil killing via the novel virulence factor MprF is based on modification of membrane lipids with l-lysine publication-title: J Exp Med doi: 10.1084/jem.193.9.1067 contributor: fullname: A Peschel – volume: 274 start-page: 8405 year: 1999 ident: ref25 article-title: Inactivation of the dlt operon in Staphylococcus aureus confers sensitivity to defensins, protegrins, and other antimicrobial peptides publication-title: J Biol Chem doi: 10.1074/jbc.274.13.8405 contributor: fullname: A Peschel – volume: 206 start-page: 143 year: 2002 ident: ref31 article-title: Role of membranes in the activities of antimicrobial cationic peptides publication-title: FEMS Microbiol Lett doi: 10.1111/j.1574-6968.2002.tb11000.x contributor: fullname: RE Hancock – volume: 42 start-page: 3929 year: 2003 ident: ref35 article-title: Histones: a novel class of lipopolysaccharide-binding molecules publication-title: Biochemistry doi: 10.1021/bi0268394 contributor: fullname: LA Augusto – volume: 58 start-page: 978 year: 2001 ident: ref3 article-title: The role of mammalian antimicrobial peptides and proteins in awakening of innate host defenses and adaptive immunity publication-title: Cell Mol Life Sci doi: 10.1007/PL00000914 contributor: fullname: D Yang – volume: 119 start-page: 115 year: 1982 ident: ref20 article-title: A sensitive silver stain for detecting lipopolysaccharides in polyacrylamide gels publication-title: Anal Biochem doi: 10.1016/0003-2697(82)90673-X contributor: fullname: CM Tsai – volume: 218 start-page: 408 year: 1996 ident: ref8 article-title: A novel antimicrobial peptide from Bufo bufo gargarizans publication-title: Biochem Biophys Res Commun doi: 10.1006/bbrc.1996.0071 contributor: fullname: CB Park – volume: 55 start-page: 1706 year: 2011 ident: ref29 article-title: Deciphering the mode of action of the synthetic antimicrobial peptide Bac8c publication-title: Antimicrob Agents Chemother doi: 10.1128/AAC.01053-10 contributor: fullname: EC Spindler – volume: 4 start-page: 1503 year: 2005 ident: ref12 article-title: Proteomic analysis of human neutrophil granules publication-title: Mol Cell Proteomics doi: 10.1074/mcp.M500143-MCP200 contributor: fullname: G Lominadze – volume: 175 start-page: 595 year: 1948 ident: ref23 article-title: A specific color reaction of methylpentoses and a spectrophotometric micromethod for their determination publication-title: J Biol Chem doi: 10.1016/S0021-9258(18)57178-7 contributor: fullname: Z Dische – volume: 165 start-page: 3268 year: 2000 ident: ref13 article-title: Pepsin-mediated processing of the cytoplasmic histone H2A to strong antimicrobial peptide buforin I. J Immunol contributor: fullname: HS Kim – volume: 229 start-page: 381 year: 1996 ident: ref6 article-title: cDNA cloning and characterization of buforin I, an antimicrobial peptide: a cleavage product of histone H2A publication-title: Biochem Biophys Res Commun doi: 10.1006/bbrc.1996.1814 contributor: fullname: HS Kim – ident: ref28 – volume: 10 start-page: 179 year: 2002 ident: ref2 article-title: How do bacteria resist human antimicrobial peptides? publication-title: Trends Microbiol doi: 10.1016/S0966-842X(02)02333-8 contributor: fullname: A Peschel – volume: 84 start-page: 589 year: 2006 ident: ref10 article-title: Beyond the walls of the nucleus: the role of histones in cellular signaling and innate immunity publication-title: Biochem Cell Biol contributor: fullname: MH Parseghian – volume: 70 start-page: 2583 year: 2002 ident: ref16 article-title: Molecular analysis of the contribution of the capsular polysaccharide and the lipopolysaccharide O side chain to the virulence of Klebsiella pneumoniae in a murine model of pneumonia publication-title: Infect Immun doi: 10.1128/IAI.70.5.2583-2590.2002 contributor: fullname: G Cortes – volume: 108 start-page: 925 year: 1958 ident: ref5 article-title: Bactericidal action of histone publication-title: J Exp Med doi: 10.1084/jem.108.6.925 contributor: fullname: JG Hirsch – volume: 72 start-page: 7107 year: 2004 ident: ref30 article-title: Capsule polysaccharide mediates bacterial resistance to antimicrobial peptides publication-title: Infect Immun doi: 10.1128/IAI.72.12.7107-7114.2004 contributor: fullname: MA Campos – volume: 28 start-page: 1350 year: 2011 ident: ref32 article-title: Antibiotic activities of host defense peptides: more to it than lipid bilayer perturbation publication-title: Nat Prod Rep doi: 10.1039/c1np00022e contributor: fullname: M Wilmes – volume: 35 start-page: 1530 year: 2000 ident: ref18 article-title: Lewis X structures in the O antigen side-chain promote adhesion of Helicobacter pylori to the gastric epithelium publication-title: Mol Microbiol doi: 10.1046/j.1365-2958.2000.01823.x contributor: fullname: NJ Edwards – volume: 119 start-page: 4 year: 2008 ident: ref1 article-title: Host antimicrobial proteins as endogenous immunomodulators publication-title: Immunol Lett doi: 10.1016/j.imlet.2008.05.003 contributor: fullname: MA Holzl – volume: 244 start-page: 253 year: 1998 ident: ref7 article-title: Mechanism of action of the antimicrobial peptide buforin II: buforin II kills microorganisms by penetrating the cell membrane and inhibiting cellular functions publication-title: Biochem Biophys Res Commun doi: 10.1006/bbrc.1998.8159 contributor: fullname: CB Park – volume: 284 start-page: 549 year: 2001 ident: ref11 article-title: Histone H1: an antimicrobial protein of Atlantic salmon (Salmo salar) publication-title: Biochem Biophys Res Commun doi: 10.1006/bbrc.2001.5020 contributor: fullname: RC Richards |
| SSID | ssj0053866 |
| Score | 2.218303 |
| Snippet | Beyond their traditional role of wrapping DNA, histones display antibacterial activity to Gram-negative and -positive bacteria. To identify bacterial... |
| SourceID | plos doaj pubmedcentral proquest gale crossref pubmed |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database |
| StartPage | e71097 |
| SubjectTerms | Antibacterial activity Antigens Antimicrobial agents Bacteria Bacterial Proteins - genetics Bacterial Proteins - metabolism Bioengineering Biology Data analysis Deoxyribonucleic acid DNA DNA binding proteins E coli Escherichia coli Escherichia coli - physiology Gene Expression Regulation, Bacterial Genes, Bacterial Gram-negative bacteria Gram-Negative Bacterial Infections - metabolism Gram-Negative Bacterial Infections - microbiology Histones Histones - metabolism Homology Host-Pathogen Interactions Humans Klebsiella Klebsiella pneumoniae Klebsiella pneumoniae - physiology Lipopolysaccharides Medical screening Microbial drug resistance Mitogens Neutrophils O Antigens - genetics O Antigens - metabolism Peptides Plasmids Polysaccharides Polysaccharides - genetics Polysaccharides - metabolism Shigella Shigella flexneri - physiology Signal Transduction Staphylococcus aureus |
| SummonAdditionalLinks | – databaseName: Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Nb9QwELXQnrggylcDLaQICTi4TeLYji9IpWpVkKASUNRbZCeTtgJlV83u_2fG9kYbVAkOva4nzu4bj-eN1vPM2BuLOQx5KHDIjOalLSS30BZcQQNtLrWAjhqcv3xVp-fl5wt5sXHVF50JC_LAAbiDrHR56zqQeauQXBfG5VUnRFlaTE1gwu6bmXUxFfZgjGKlYqOc0PlB9Mv-Yt7Dvs-qJPK0kYi8Xv-4K88Wv-fDbZTz75OTG6no5CF7EDlkehi--xa7B_0jthWjdEjfRSnp94_ZhzOOyJHgZhoFGYaUjmPxHi694nfqglqzTanPJPXqwz2kv669VPcTdn5y_OPolMcbE3ijTLHkAqStZJURiWjBtE5n1ihkEJ3R0kqdNa4wqrPaNpiGENWuK5uqQZZdONUoEE_ZrMfXbLPUYN2nDM7VZVAa11ppBVawgAzIidzJhPE1fPUiCGPU_t8xjQVFwKEmuOsId8I-EsajLcla-w_Q2XV0dv0vZyfsFXmoDj2iY3DWh6WuBNqXVcJeewuStujp7MylXQ1D_ens538Yff82MXobjbo5-rqxsV8BfxNJZk0sdyaWGKDNZHib1tMalQGrLeE1CFSGT67X2O3De-MwTUrn4XqYr8iGpOBwdpGwZ2FJjsgWglhzZRKmJ4t1Av10pL--8sriJHMlTfH8Lnz1gt0v_NUhpIC-w2bLmxXsIoFbupc-Vv8AmQNBuw priority: 102 providerName: Directory of Open Access Journals – databaseName: ProQuest Public Health Database dbid: 8C1 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1Lb9QwELZgERIXRMujgQIBIQEHt0kc2_EFtK0oBUSLgFa9WY7jLJUgWTa7B_49M443NKhCXONZJzsPz-dk5jMhzwzkMMChjrpESZqbjFPjqowKZ12VcslcjQ3OH4_E4Un-_oyfhRduXSirXK-JfqGuWovvyHchr_vGbZG8nv-keGoUfl0NR2hcJddSyHNY0lfsDyUeEMtChHY5JtPdYJ2dedu4HZ9bkerpQjryrP3D2jyZf2-7y4Dn3_WTFxLSwS1yMyDJeNqbfoNccc0mud6fLflrk2yEqO3iF4Fa-uVt8uqYTpslEnDGn3qChi5-uzA_6JGbeQbweK9nbzYx9p3EnkSkcfGHc0_dfYecHLz5un9IwwkK1AqVLSlz3BS8SBBUVE5VpUyMEoAoaiW54TKxZaZEbaSxkJbKGgyT28IC6s5KYYVjd8mkgdtskVjBPlAomKtOXK7KynDDYEfrABGVLC15ROhakXreE2Vo_7VMwgaj14hGxeug-IjsobYHWaS59hfaxUyHqNFJXqYVPBZPKwE7q0yVaVEzlucGcIlTWUQeo6103zM6BKue5rJgIJ8XEXnqJZDqosFamplZdZ1-d3z6H0JfPo-EngehugWrWxP6F-A_IYXWSHJ7JAkBa0fDW-hZa610-o9rwy_X3nb58JNhGCfF-rjGtSuUQWo4mJ1F5F7vnINmM4YoulARkSO3Hal-PNKcf_NM40h7xVV2_9-P9YDcyPwhIch1vk0my8XKPQSotiwf-Xj8DeskO5w priority: 102 providerName: ProQuest – databaseName: Scholars Portal Open Access Journals dbid: M48 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3db9MwELdGeeEFMb4WGBAQEvCQKvFn_ABoIKaBBJOAor1FduKUiSkpTSvBf8-d40QEFWmv9dlpz3e93yl3vyPkqYEYBjjUJS7VKuGGisS4iibSla7KhGKuxgbnj5_kyYJ_OBNne2SY2RoU2O1M7XCe1GJ9Mf_18_drcPiXfmqDyoZN81XbuLmPmVpdIVcph1wdi_n4-F4BvFvK0ED3v52TAOV5_Md_69nqou12QdF_Kyr_ClHHN8j1gC3jo94Y9smea26S_eC9Xfw8UEy_uEVenSagUSTijANRQxdjmVbSuKVnAo9tz-JsYuw_iT0rcePiH-eewvs2WRy_-_r2JAmTFJJSarpJmBMmF3mK4KJyurIqNVoCsqi1EkaotLRUy9ooU0J4sjVcEC_zEtA3tbKUjt0hswYec0BiDfmg1HBWnTqubWWEYZDZOkBGlmVWRCQZ1FesesKMwr81U5Bo9HooUN1FUHdE3qCOR1mku_YftOtlEbynSLnNKvhaIqskZFhU2yyvGePcAD5xmkbkEd5Q0feOjk5bHHGVM5DneUSeeAmkvGiwpmZptl1XvD_9dgmhL58nQs-CUN3CXZcm9DHAb0IqrYnk4UQSHLecLB-gPQ1a6SALY56bQKawc7Cx3cuPx2U8FOvkGtduUQYp4uB0FpG7vUmOmqUM0XSuI6ImxjpR_XSlOf_uGceR_kpoeu8Sz71PrlE_MQSJzw_JbLPeugeA2zb2oXfFP6-aQbM priority: 102 providerName: Scholars Portal |
| Title | O-antigen protects gram-negative bacteria from histone killing |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/23951089 https://www.proquest.com/docview/1430254360 https://search.proquest.com/docview/1426017243 https://pubmed.ncbi.nlm.nih.gov/PMC3738592 https://doaj.org/article/04b1dbfe51d648729b18f3344a812e92 http://dx.doi.org/10.1371/journal.pone.0071097 |
| Volume | 8 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3db9MwELe2IiReEBsfC4wSEBLwkDaJYzt-QWqndQPUrhoM9S2yHadUWtOqaR_47zk7TrWgPSBe_FBf3PQ-cnfp3e8Qei_Ah0EcqgMdchYkIiaB0HkcUK10HhGGdWEanMcTenmTfJ2R2QEiTS-MLdpXctErb5e9cvHL1laul6rf1In1p-Mzg8ZDeNw_RIegoE2KXj9-wYApdT1ymEV9J5LeelXqnnWo3Azei7EJLcxw9zvuyKL275_NnfXtqrov8Py7fvKOQxo9QY9dJOkP6js-Qge6PEYP69mSv4_RkbPayv_ooKU_PUWfr4JBuTUAnP60Bmio_IuNWAYTPbcI4P6wRm8Wvuk78S2ISKn9bwsL3f0M3YzOf5xdBm6CQqAoj7cB1kSkJA1NUJFrnksWCk4hoig4I4KwUMmY00IwocAtyQIEk6hUQdQdS6qoxs9Rp4SvOUE-hzyQcjirCHXCZS6IwJDRaoiIJI4k8VDQMDJb10AZmf23jEGCUXMkMzLInAw8NDTc3tMamGv7wWozz5ywszCRUQ63RaKcQmYVcxmlBcZJIiAu0Tz20Bsjq6zuGd0bazZIWIqBPkk99M5SGKiL0tTSzMWuqrIvVz__gej7dYvogyMqViB1JVz_AvwmA6HVojxtUYLBqtb2idGshisVZF_YYhLQEK5stO3-7bf7bXOoqY8r9WpnaAw0HJyOPfSiVs49ZxtV9xBrqW2L9e0dMDyLNO4M7eV_X_kKPYrt_BADg36KOtvNTr-GKG4ru2C7MwZrehaZdXTRRQ-G55Ppdde-F4F1nKRda9t_ANeVSvc |
| link.rule.ids | 230,315,730,783,787,867,888,2109,2228,12068,12235,12777,21400,24330,27936,27937,31731,31732,33278,33279,33385,33386,33756,33757,43322,43591,43612,43817,53804,53806,74073,74342,74363,74630 |
| linkProvider | National Library of Medicine |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3fb9MwELagCMELYuPHMgYLCAl48JbEsRO_gDpE17GtQ7BNe7OcxCmTWFKa9oH_njvHKQuaEK-5q5Pe-XyfE993hLzWkMMAhxpqApnQWEecalNEVJjcFCFPmCmxwPl4IsZn8ecLfuFeuDXuWGW3JtqFuqhzfEe-C3ndFm6L4MPsJ8WuUfh11bXQuE3ugCTEDgbpaL9biSGWhXDlciwJd513dmZ1ZXZsbkWqp2vpyLL2r9bmwexH3dwEPP8-P3ktIY0ekgcOSfrD1vVr5Jap1sndtrfkr3Wy5qK28d86aul3j8j7EzqsFkjA6X9pCRoaf3-ur-jETC0DuL_XsjdrH-tOfEsiUhn_8NJSdz8mZ6NPpx_H1HVQoLmQ0YIyw3XK0wBBRWFkkSWBlgIQRSkTrnkS5FkkRakTnUNaykpwTJynOaDuKBO5MOwJGVRwmw3iS9gHCgljlYGJZVZorhnsaA0gooyFGfcI7QypZi1RhrJfyxLYYLQWUWh45QzvkT209koXaa7thXo-VS5qVBBnYQGPxcNCwM4qklmYlozFsQZcYmTkkW30lWprRlfBqoZxkjLQj1OPvLIaSHVR4VmaqV42jTo4Of8PpW9fe0pvnFJZg9dz7eoX4D8hhVZPc6unCQGb98QbOLM6qzTqz9SGX3az7Wbxy5UYB8XzcZWpl6iD1HAwOvPI03ZyriwbMUTRqfRI0pu2PdP3JdXld8s0jrRXXEab_36sbXJvfHp8pI4OJofPyP3INgxB3vMtMljMl-Y5wLZF9sLG5m8-7D67 |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1Rb9MwELagCMQLYgO2wGABIQEPXpM4duKXoW5QNgbdBGzam-UkTpkESWnaB_797hw3LGhCvMZXJz3f-T4nd98R8lJDDAMcaqgJZEJjHXGqTRFRYXJThDxhpsQC588TcXAafzzn5y7_qXFplas90W7URZ3jO_IhxHVbuC2CYenSIk7ejd_OflHsIIVfWl07jZvkFkTFGLsZpPtdugf4tRCudI4l4dCt1M6srsyOjbNI-3QlNFkG_26fHsx-1M11IPTvXMorwWl8n9xzqNIftWawRm6Yap3cbvtM_l4na86DG_-1o5l-84DsHtNRtUAyTv-kJWto_A9z_ZNOzNSygft7LZOz9rEGxbeEIpXxjy4sjfdDcjp-_23_gLpuCjQXMlpQZrhOeRogwCiMLLIk0FIAuihlwjVPgjyLpCh1onMIUVkJixTnaQ4IPMpELgx7RAYV3GaT-BLOhELCXGVgYpkVmmsGp1sD6ChjYcY9QleKVLOWNEPZL2cJHDZajShUvHKK98gearuTRcpre6GeT5XzIBXEWVjAY_GwEHDKimQWpiVjcawBoxgZeWQb10q19aOd46pRnKQM5OPUIy-sBNJeVGhAU71sGnV4fPYfQl-_9IReOaGyhlXPtatlgP-EdFo9ya2eJDhv3hveRMtaaaVRf8wcfrmytuuHn3fDOCnmylWmXqIM0sTB7MwjG61xdpqNGCLqVHok6ZltT_X9keriu2UdRwosLqPH_36sbXIH3FJ9OpwcPSF3I9s7BCnQt8hgMV-ap4DgFtkz65qXG3xCvg |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=O-antigen+protects+gram-negative+bacteria+from+histone+killing&rft.jtitle=PloS+one&rft.au=Chaput%2C+Catherine&rft.au=Spindler%2C+Eileen&rft.au=Gill%2C+Ryan+T&rft.au=Zychlinsky%2C+Arturo&rft.date=2013-08-08&rft.eissn=1932-6203&rft.volume=8&rft.issue=8&rft.spage=e71097&rft.epage=e71097&rft_id=info:doi/10.1371%2Fjournal.pone.0071097&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1932-6203&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1932-6203&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1932-6203&client=summon |