The Joint Effect of hOGG1, APE1, and ADPRT Polymorphisms and Cooking Oil Fumes on the Risk of Lung Adenocarcinoma in Chinese Non-Smoking Females

• Published in: PloS one Vol. 8; no. 8; p. e71157
• Main Authors: Xue, Xiaoxia, Yin, Zhihua, Lu, Yao, Zhang, Haibo, Yan, Ying, Zhao, Yuxia, Li, Xuelian, Cui, Zeshi, Yu, Miao, Yao, Lu, Zhou, Baosen
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 12.08.2013; Public Library of Science (PLoS)
• Subjects: 8-Hydroxyguanine; Adenocarcinoma; Adenocarcinoma - etiology; Adenocarcinoma - genetics; Adenosine; Adenosine diphosphate; ADP Ribose Transferases - genetics; Air Pollution, Indoor - adverse effects; Alleles; ATPases; Base excision repair; Biology; Cancer; Cancer research; Carcinogens; Case-Control Studies; Cooking; Cooking oils; Demographics; Deoxyribonucleic acid; Dietary Fats, Unsaturated - adverse effects; DNA; DNA glycosylase; DNA Glycosylases - genetics; DNA repair; DNA-(Apurinic or Apyrimidinic Site) Lyase - genetics; Edible vegetable oils; Endonuclease; Environmental associations; Enzymes; Epidemiology; Female; Females; Fumes; Gene polymorphism; Gene-Environment Interaction; Genes; Genotype; Genotype-environment interactions; Genotypes; Health risks; Hospitals; Humans; Laboratories; Lung cancer; Lung diseases; Lung Neoplasms - etiology; Lung Neoplasms - genetics; Mathematics; Medical research; Medicine; Middle Aged; Nucleases; Odds Ratio; Oil; Polymerase chain reaction; Polymorphism; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Population; Public health; Radiation therapy; Restriction fragment length polymorphism; Risk; Single nucleotide polymorphisms; Single-nucleotide polymorphism; Smoking; Studies; Womens health; China

The human 8-oxoguanine DNA glycosylase 1 (hOGG1), apurinic/apyrimidinic endonuclease 1 (APE1), and adenosine diphosphate ribosyl transferase (ADPRT) genes play an important role in the DNA base excision repair pathway. Single nucleotide polymorphisms (SNPs) in critical genes are suspected to be asso...