Serological Evidence of an Early Seroconversion to Simian Virus 40 in Healthy Children and Adolescents

• Published in: PloS one Vol. 8; no. 4; p. e61182
• Main Authors: Taronna, Angelo, Mazzoni, Elisa, Corallini, Alfredo, Bononi, Ilaria, Pietrobon, Silvia, Guerra, Giovanni, Palmonari, Caterina, Borgna-Pignatti, Caterina, Comar, Manola, Bovenzi, Massimo, Casali, Ferruccio, Marci, Roberto, Rezza, Giovanni, Barbanti-Brodano, Giuseppe, Tognon, Mauro, Martini, Fernanda
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 25.04.2013; Public Library of Science (PLoS)
• Subjects: Adolescent; Adolescents; Age; Analysis; Antibodies; Antibodies, Viral - blood; Antibodies, Viral - immunology; Antigens; Antiviral agents; Biology; Capsid protein; Capsid Proteins - chemistry; Child; Child, Preschool; Children; Contamination; Early Diagnosis; Enzyme-Linked Immunosorbent Assay; Enzymes; Epitopes - immunology; Female; Health; Humans; Immunization; Immunoassays; Immunoglobulin G; Immunoglobulin M; Immunoglobulin M - blood; Immunoglobulin M - immunology; Infant; Infant, Newborn; Infants; Infection; Infections; Laboratories; Male; Medicine; Monkeys; Peptide Fragments - immunology; Peptides; Polyomavirus Infections - blood; Polyomavirus Infections - diagnosis; Seroconversion; Serologic Tests; Simian virus 40 - immunology; Simian virus 40 - physiology; Studies; Synthetic peptides; Teenagers; Tumor Virus Infections - blood; Tumor Virus Infections - diagnosis; Vaccines; Vice presidents (Organizations); Viral proteins; Viruses

At present Simian virus 40 (SV40) infection in humans appears to be transmitted independently from early contaminated vaccines. In order to test the spread of SV40 infection in children, an immunologic assay employing specific SV40 synthetic peptides corresponding to its viral protein (VP) antigens...