Plasma Concentrations Predict Aortic Expression of Growth-Arrest-Specific Protein 6 in Patients Undergoing Coronary Artery Bypass Grafting

• Published in: PloS one Vol. 8; no. 11; p. e79452
• Main Authors: Lee, Chien-Hsing, Shieh, Yi-Shing, Tsai, Chien-Sung, Hung, Yi-Jen, Tsai, Yi-Ting, Lin, Chih-Yuan
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 13.11.2013; Public Library of Science (PLoS)
• Subjects: Aged; Angina pectoris; Aorta; Aorta - metabolism; Apoptosis; Axl protein; Axl Receptor Tyrosine Kinase; Biomarkers - blood; Calcification; Cardiovascular disease; Case-Control Studies; Cell adhesion; Cell adhesion & migration; Cell adhesion molecules; Coronary artery; Coronary Artery Bypass; Coronary Artery Disease - genetics; Coronary Artery Disease - metabolism; Coronary Artery Disease - surgery; Coronary vessels; Correlation; Cytokines; E-selectin; Endocrinology; Fasting; Female; Gene Expression; Glucose; Grafting; Growth; Health aspects; Heart surgery; Hospitals; Humans; Hypertension; Immunoassays; Immunohistochemistry; Inflammation; Intercellular Signaling Peptides and Proteins - blood; Intercellular Signaling Peptides and Proteins - genetics; Intercellular Signaling Peptides and Proteins - metabolism; Internal medicine; Ischemia; Kinases; Ligands; Lupus; Male; Markers; Medical research; Metabolism; Middle Aged; Mortality; Patients; Polymerase chain reaction; Protein-tyrosine kinase receptors; Proteins; Proto-Oncogene Proteins - genetics; Proto-Oncogene Proteins - metabolism; Receptor Protein-Tyrosine Kinases - genetics; Receptor Protein-Tyrosine Kinases - metabolism; Reverse transcription; Risk Factors; Smooth muscle; Surgery; Tyrosine; Vascular cell adhesion molecule 1; Western blotting; Taiwan
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0079452

The tyrosine kinase receptor Axl is expressed in the vasculature, and growth arrest-specific protein 6 (Gas6) is its ligand. Plasma Gas6 levels have been shown to be associated with endothelial dysfunction markers and cardiovascular events. We set out to determine the plasma Gas6 levels in patients...