Oxygen environment and islet size are the primary limiting factors of isolated pancreatic islet survival

• Published in: PloS one Vol. 12; no. 8; p. e0183780
• Main Authors: Komatsu, Hirotake, Cook, Colin, Wang, Chia-Hao, Medrano, Leonard, Lin, Henry, Kandeel, Fouad, Tai, Yu-Chong, Mullen, Yoko
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 23.08.2017; Public Library of Science (PLoS)
• Subjects: Analysis; Anoxia; Apoptosis; Beta cells; Biology and Life Sciences; Care and treatment; Cell culture; Cell Survival; Computation; Computer applications; Computer simulation; Development and progression; Diabetes; Diabetes mellitus; Electrical engineering; Endocrinology; Engineering and Technology; Gangrene; Genetic aspects; Glucose; Histology; Humans; Hypoxia; Immunosuppression; In vitro methods and tests; Insulin; Islet cells; Islets of Langerhans; Islets of Langerhans - metabolism; Limiting factors; Liver transplants; Logistic Models; Medicine and Health Sciences; Metabolism; Necrosis; Optimization; Oxygen; Oxygen - metabolism; Oxygen Consumption; Oxygen tension; Pancreas; Pancreas transplantation; Pancreatic islet transplantation; Physical Sciences; Physiological aspects; Physiology; Regression analysis; Research and Analysis Methods; Rodents; Simulation; Survival; Tension; Toxicity; Transplantation; Transplants & implants; Type 1 diabetes; Viability; Xenografts; United States; United States > US; California

Type 1 diabetes is an autoimmune disease that destroys insulin-producing beta cells in the pancreas. Pancreatic islet transplantation could be an effective treatment option for type 1 diabetes once several issues are resolved, including donor shortage, prevention of islet necrosis and loss in pre- a...