Oxygen environment and islet size are the primary limiting factors of isolated pancreatic islet survival - Komatsu, Hirotake; Cook, Colin; Wang, Chia-Hao; Medrano, Leonard; Lin, Henry; Kandeel, Fouad; Tai, Yu-Chong; Mullen, Yoko (PloS one, 2017)
Keywords: Analysis; Anoxia; Apoptosis; Beta cells; Biology and Life Sciences; Care and treatment; Cell culture; Cell Survival; Computation; Computer applications; Computer simulation; Development and progression; Diabetes; Diabetes mellitus; Electrical engineering; Endocrinology; Engineering and Technology; Gangrene; Genetic aspects; Glucose; Histology; Humans; Hypoxia; Immunosuppression; In vitro methods and tests; Insulin; Islet cells; Islets of Langerhans; Islets of Langerhans - metabolism; Limiting factors; Liver transplants; Logistic Models; Medicine and Health Sciences; Metabolism; Necrosis; Optimization; Oxygen; Oxygen - metabolism; Oxygen Consumption; Oxygen tension; Pancreas; Pancreas transplantation; Pancreatic islet transplantation; Physical Sciences; Physiological aspects; Physiology; Regression analysis; Research and Analysis Methods; Rodents; Simulation; Survival; Tension; Toxicity; Transplantation; Transplants & implants; Type 1 diabetes; Viability; Xenografts; United States; United States--US; California