An Eighteen Serum Cytokine Signature for Discriminating Glioma from Normal Healthy Individuals

• Published in: PloS one Vol. 10; no. 9; p. e0137524
• Main Authors: Nijaguna, Mamatha B, Patil, Vikas, Hegde, Alangar S, Chandramouli, Bangalore A, Arivazhagan, Arimappamagan, Santosh, Vani, Somasundaram, Kumaravel
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 21.09.2015; Public Library of Science (PLoS)
• Subjects: Accuracy; Adult; Angiogenesis; Astrocytoma; Astrocytoma - blood; Astrocytoma - diagnosis; Bioindicators; Biology; Biomarkers; Biomarkers, Tumor - blood; Brain; Brain - pathology; Brain cancer; Brain Neoplasms - blood; Brain Neoplasms - diagnosis; Cancer therapies; Cytokines; Cytokines - blood; Development and progression; Encyclopedias; Gene expression; Genetic aspects; Genomes; Glioblastoma - blood; Glioblastoma - diagnosis; Glioma; Glioma - blood; Glioma - diagnosis; Gliomas; Humans; Medical diagnosis; Medical imaging; Medical prognosis; Mental health; Middle Aged; Neurosurgery; NMR; Nuclear magnetic resonance; Patients; Physiological aspects; Science; Support Vector Machine; Test sets; Training; Tumors; Young Adult; India

Glioblastomas (GBM) are largely incurable as they diffusely infiltrate adjacent brain tissues and are difficult to diagnose at early stages. Biomarkers derived from serum, which can be obtained by minimally invasive procedures, may help in early diagnosis, prognosis and treatment monitoring. To deve...