Metabolomic derangements are associated with mortality in critically ill adult patients

• Published in: PloS one Vol. 9; no. 1; p. e87538
• Main Authors: Rogers, Angela J, McGeachie, Michael, Baron, Rebecca M, Gazourian, Lee, Haspel, Jeffrey A, Nakahira, Kiichi, Fredenburgh, Laura E, Hunninghake, Gary M, Raby, Benjamin A, Matthay, Michael A, Otero, Ronny M, Fowler, Vance G, Rivers, Emanuel P, Woods, Christopher W, Kingsmore, Stephen, Langley, Ray J, Choi, Augustine M K
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 30.01.2014; Public Library of Science (PLoS)
• Subjects: Adults; Aged; Amino acids; Analysis; Bayes Theorem; Bayesian analysis; Biology; Biomarkers; Biomarkers - metabolism; Carbohydrates; Community-Acquired Infections - metabolism; Community-Acquired Infections - mortality; Critical care; Critical Illness - mortality; Emergency medical care; Enrollments; Female; Gene expression; Genomes; Genotype & phenotype; Hormones; Hospital Mortality; Hospital patients; Hospitals; Humans; Identification methods; Infection; Intensive care; Intensive Care Units; Lactates; Lactic acid; Lipid metabolism; Lipids; Male; Mathematics; Medicine; Metabolism; Metabolites; Metabolomics; Metabolomics - methods; Middle Aged; Mortality; Nucleotides; Patient outcomes; Patients; Prognosis; Replication; Sepsis; Sepsis - metabolism; Sepsis - mortality; Sucrose; Sugar; New York; California; United States > US; New Mexico; Massachusetts

To identify metabolomic biomarkers predictive of Intensive Care Unit (ICU) mortality in adults. Comprehensive metabolomic profiling of plasma at ICU admission to identify biomarkers associated with mortality has recently become feasible. We performed metabolomic profiling of plasma from 90 ICU subje...