Informing Evidence-Based Decision-Making for Patients with Comorbidity: Availability of Necessary Information in Clinical Trials for Chronic Diseases

• Published in: PloS one Vol. 7; no. 8; p. e41601
• Main Authors: Boyd, Cynthia M., Vollenweider, Daniela, Puhan, Milo A.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 03.08.2012; Public Library of Science (PLoS)
• Subjects: Access to Information; Anticholesteremic agents; Anticoagulants; Asthma; Chronic conditions; Chronic Disease; Chronic diseases; Chronic illnesses; Chronic obstructive pulmonary disease; Clinical decision making; Clinical trials; Clinical Trials as Topic - instrumentation; Clinical Trials as Topic - methods; Comorbidity; Coronary artery disease; Corticoids; Corticosteroids; Decision Making; Diabetes mellitus; Diabetes Mellitus - drug therapy; Diabetes Mellitus - mortality; Disease control; Diuretics; Evidence-Based Medicine - instrumentation; Evidence-Based Medicine - methods; Female; Heart diseases; Humans; Lung diseases; Male; Medical research; Medicine; Metformin; Obstructive lung disease; Patients; Public health; Pulmonary Disease, Chronic Obstructive - drug therapy; Pulmonary Disease, Chronic Obstructive - mortality; Stroke; Stroke - drug therapy; Stroke - mortality; Studies; Surveys; United States > US; Maryland; Baltimore Maryland
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0041601

The population with multiple chronic conditions is growing. Prior studies indicate that patients with comorbidities are frequently excluded from trials but do not address whether information is available in trials to draw conclusions about treatment effects for these patients. We conducted a literat...