Characteristics and Their Clinical Relevance of Respiratory Syncytial Virus Types and Genotypes Circulating in Northern Italy in Five Consecutive Winter Seasons

• Published in: PloS one Vol. 10; no. 6; p. e0129369
• Main Authors: Esposito, Susanna, Piralla, Antonio, Zampiero, Alberto, Bianchini, Sonia, Di Pietro, Giada, Scala, Alessia, Pinzani, Raffaella, Fossali, Emilio, Baldanti, Fausto, Principi, Nicola
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 05.06.2015; Public Library of Science (PLoS)
• Subjects: Child, Preschool; Children; DNA, Complementary - chemistry; DNA, Complementary - genetics; Ear diseases; Emergency medical care; Epidemiology; Family medical history; Female; Genetic aspects; Genetic diversity; Genotype; Genotype & phenotype; Genotypes; Hospitalization; Host-Pathogen Interactions; Humans; Illnesses; Infant; Infant, Newborn; Infection; Infections; Influenza; Intensive care; Italy - epidemiology; Male; Molecular Sequence Data; Nucleotides; Pediatrics; Phylogeny; Pneumonia; Polymerase chain reaction; Positive selection; Prevalence; Proteins; Respiratory syncytial virus; Respiratory Syncytial Virus Infections - epidemiology; Respiratory Syncytial Virus Infections - virology; Respiratory Syncytial Virus, Human - classification; Respiratory Syncytial Virus, Human - genetics; Respiratory Syncytial Virus, Human - physiology; Respiratory tract; Respiratory tract diseases; Reverse Transcriptase Polymerase Chain Reaction; RNA, Viral - genetics; Seasons; Sequence Analysis, DNA; Species Specificity; Strains (organisms); Vaccines; Virology; Viruses; Winter; Italy

In order to investigate the genetic diversity and patterns of the co-circulating genotypes of respiratory syncytial virus (RSV) and their possible relationships with the severity of RSV infection, we studied all of the RSV-positive nasopharyngeal samples collected from children during five consecuti...