Inflammatory Serum Proteins Are Severely Altered in Metastatic Gastric Adenocarcinoma Patients from the Chinese Population

• Published in: PloS one Vol. 10; no. 4; p. e0123985
• Main Authors: Wang, Jiangnan, Ma, Rong, Sharma, Ashok, He, Mingfang, Xue, Jing, Wu, Jianzhong, Dun, Boying, Li, Gang, Wang, Xiaoxiao, Ji, Minghua, She, Jin-Xiong, Tang, Jinhai
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 17.04.2015; Public Library of Science (PLoS)
• Subjects: Acute phase proteins; Acute phase substances; Adenocarcinoma; Adenocarcinoma - blood; Adenocarcinoma - pathology; Aged; Angiogenesis; Asian Continental Ancestry Group; Biomarkers; Biomarkers - blood; Biotechnology; Blood proteins; Blood Proteins - metabolism; Breast cancer; Cancer; Cell adhesion & migration; Chemokines; China; Comparative analysis; CXC chemokines; Diagnostic systems; Female; Gastric cancer; Hospitals; Humans; Inflammation; Inflammation - blood; Inflammation - pathology; Male; Medical diagnosis; Medical prognosis; Medicine; Metastases; Metastasis; Middle Aged; Multiplexing; Patients; Pharmaceutical sciences; Prognosis; Prostate cancer; Proteins; Sampling methods; Serum levels; Serum proteins; Stomach cancer; Stomach Neoplasms - blood; Stomach Neoplasms - pathology; Subgroups; Tumor necrosis factor-TNF; China

Inflammation is one of the major hallmarks of cancer. This study was designed to profile a panel of inflammatory mediators in gastric adenocarcinoma (GA) and to identify their potential differences separately in metastatic and non-metastatic patient subgroups. Serum samples from 216 GA patients and...