DNA Vaccine Delivered by a Needle-Free Injection Device Improves Potency of Priming for Antibody and CD8+ T-Cell Responses after rAd5 Boost in a Randomized Clinical Trial - Graham, Barney S.; Enama, Mary E.; Nason, Martha C.; Gordon, Ingelise J.; Peel, Sheila A.; Ledgerwood, Julie E.; Plummer, Sarah A.; Mascola, John R.; Bailer, Robert T.; Roederer, Mario; Koup, Richard A.; Nabel, Gary J. (PloS one, 2013)
Keywords: Adenoviridae - genetics; Adenoviruses; Adolescent; Adult; Adults; Antibodies, Viral - immunology; Avian flu; Binding sites; Biology; Carbon dioxide; CD4 antigen; CD8 antigen; CD8-Positive T-Lymphocytes - immunology; Clinical trials; Delivery scheduling; Deoxyribonucleic acid; DNA; DNA vaccines; DNA, Recombinant - genetics; Dose-Response Relationship, Immunologic; Drug delivery systems; Enzyme-linked immunosorbent assay; Female; Hepatitis; HIV; HIV-1 - immunology; HIV-1 - metabolism; Human immunodeficiency virus; Humans; Immunity, Cellular - immunology; Immunity, Humoral - immunology; Immunization, Secondary - methods; Immunogenicity; Infectious diseases; Injection; Injections; Interferon; Lymphocytes T; Male; Medicine; Middle Aged; Peptide Fragments - metabolism; Priming; Safety; Safety regulations; Studies; Syringes; T cells; Vaccination; Vaccination - instrumentation; Vaccines; Vaccines, DNA - administration & dosage; Vaccines, DNA - adverse effects; Vaccines, DNA - genetics; Vaccines, DNA - immunology; Vice presidents (Organizations); West Nile virus; Young Adult; γ-Interferon; United States--US; Maryland