High Prevalence of Tuberculosis and Serious Bloodstream Infections in Ambulatory Individuals Presenting for Antiretroviral Therapy in Malawi

• Published in: PloS one Vol. 7; no. 6; p. e39347
• Main Authors: Bedell, Richard A., Anderson, Suzanne T. B., van Lettow, Monique, Åkesson, Ann, Corbett, Elizabeth L., Kumwenda, Moses, Chan, Adrienne K., Heyderman, Robert S., Zachariah, Rony, Harries, Anthony D., Ramsay, Andrew R.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 22.06.2012; Public Library of Science (PLoS)
• Subjects: Adult; Adults; AIDS-Related Opportunistic Infections - diagnosis; AIDS-Related Opportunistic Infections - epidemiology; Analysis; Anemia; Antiretroviral agents; Antiretroviral drugs; Antiretroviral therapy; Antiretroviral Therapy, Highly Active; Automation; Bacteria; Blood; Blood culture; Blood tests; Candidiasis; CD4 antigen; Cell number; Chronic illnesses; Clinical trials; Comorbidity; Culture; Diarrhea; Drug therapy; Female; Fever; Genomes; Health aspects; Hematology; Highly active antiretroviral therapy; HIV; HIV Infections - drug therapy; HIV Infections - epidemiology; Hospitals; Humans; Infections; Lung diseases; Lymphadenopathy; Lymphocytes; Lymphopenia; Malawi - epidemiology; Male; Medical diagnosis; Medical research; Medicine; Microscopy; Middle Aged; Mortality; Multivariate analysis; Nurses; Prevalence; Prospective Studies; Salmonella; Salmonella Infections - diagnosis; Salmonella Infections - epidemiology; Sputum; Sputum - microbiology; Streptococcus infections; Studies; Surveillance; Therapy; Tuberculosis; Tuberculosis - diagnosis; Tuberculosis - epidemiology; Weight loss; Malawi

Tuberculosis (TB) and serious bloodstream infections (BSI) may contribute to the high early mortality observed among patients qualifying for antiretroviral therapy (ART) with unexplained weight loss, chronic fever or chronic diarrhea. A prospective cohort study determined the prevalence of undiagnos...