Rate of hepatitis C viral clearance by human livers in human patients: Liver transplantation modeling primary infection and implications for studying entry inhibition

• Published in: PloS one Vol. 12; no. 7; p. e0180719
• Main Authors: Hughes, Jr, Michael G, Tucker, William W, Reddy, Sreelatha, Brier, Michael E, Koch, David, McClain, Craig J, Jonsson, Colleen B, Matoba, Nobuyuki, Chung, Donghoon
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 21.07.2017; Public Library of Science (PLoS)
• Subjects: Age; Aged; Allografts; Biology and Life Sciences; Blood Transfusion; Circulation; Drug therapy; Female; Half-life; Hepacivirus - physiology; Hepatitis; Hepatitis C; Hepatitis C, Chronic - blood; Hepatitis C, Chronic - surgery; Hepatitis C, Chronic - virology; Hepatology; Humans; Immunosuppression; Immunotherapy; Infections; Inhibition; Interferon; Kinetics; Liver; Liver - virology; Liver cirrhosis; Liver Transplantation; Liver transplants; Male; Medicine and Health Sciences; Middle Aged; Models, Biological; Pathogenesis; Patients; Real-Time Polymerase Chain Reaction; Reperfusion; Research and analysis methods; Reverse Transcriptase Polymerase Chain Reaction; Risk factors; RNA, Viral - blood; Surgery; Time Factors; Toxicology; Transplantation; Transplants & implants; Variability; Viral Load; Virus Internalization; Viruses; United States > US; Kentucky

To better understand the dynamics of early hepatitis C virus (HCV) infection, we determined how rapidly non-cirrhotic HCV-uninfected liver allografts clear HCV from the circulation of cirrhotic HCV-infected patients at the time of transplantation but before administration of immunosuppression. Speci...