PARP-1 Val762Ala Polymorphism and Risk of Cancer: A Meta-Analysis Based on 39 Case-Control Studies

• Published in: PloS one Vol. 9; no. 5; p. e98022
• Main Authors: Qin, Qin, Lu, Jing, Zhu, Hongcheng, Xu, Liping, Cheng, Hongyan, Zhan, Liangliang, Yang, Xi, Zhang, Chi, Sun, Xinchen
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 22.05.2014; Public Library of Science (PLoS)
• Subjects: Adenosine diphosphate; Alanine - genetics; Apoptosis; Biomarkers; Bladder cancer; Breast cancer; Cancer; Cancer research; Carcinogenesis; Carcinogens; Case-Control Studies; Cell cycle; Cervix; Chromatin; Deoxyribonucleic acid; Development and progression; DNA; DNA damage; DNA repair; Enzymes; Genes; Genetic aspects; Genetic Predisposition to Disease; Glioma; Gliomas; Health aspects; Health risk assessment; Health risks; Humans; Ionizing radiation; Lung cancer; Lungs; Medicine and Health Sciences; Meta-analysis; Minority & ethnic groups; Monosaccharides; Neoplasms - genetics; Oncology; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose); Poly(ADP-ribose) polymerase; Poly(ADP-ribose) Polymerases - genetics; Polymorphism; Polymorphism, Genetic; Proteins; Ribose; Risk; Risk factors; Risk reduction; Studies; Subgroups; Valine - genetics; XRCC1 protein; China

Poly(ADP-ribose) polymerase-1 (PARP-1) is a nuclear chromatin-associated enzyme involved in several important cellular processes, particularly in the DNA repair system. PARP-1 rs1136410: C>T is among the most studied polymorphisms and likely involved in human carcinogenesis. However, results from...