Improvement in Human Immune Function with Changes in Intestinal Microbiota by Salacia reticulata Extract Ingestion: A Randomized Placebo-Controlled Trial

• Published in: PloS one Vol. 10; no. 12; p. e0142909
• Main Authors: Oda, Yuriko, Ueda, Fumitaka, Utsuyama, Masanori, Kamei, Asuka, Kakinuma, Chihaya, Abe, Keiko, Hirokawa, Katsuiku
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 02.12.2015; Public Library of Science (PLoS)
• Subjects: Age; Animals; Bacteria; Biomarkers - metabolism; Blood; Blood cells; Cell proliferation; Clinical trials; Dendritic cells; Double-Blind Method; Eating; Epithelial cells; Gastrointestinal Microbiome - drug effects; Gene expression; Gene Expression Profiling; Genes; High-Throughput Nucleotide Sequencing - methods; Humans; Immune response; Immune system; Immunology; Ingestion; Intestinal microflora; Intestinal Mucosa - drug effects; Intestinal Mucosa - immunology; Intestinal Mucosa - metabolism; Intestinal Mucosa - microbiology; Intestine; Laboratories; Life sciences; Lymphocytes T; Male; Medical research; Methods; Microbiota; Microbiota (Symbiotic organisms); Middle Aged; Older people; Pharmaceuticals; Plant Extracts - pharmacology; Polyphenols; Prebiotics; R&D; Rats; Research & development; Rodents; Salacia; Salacia - chemistry; Sugar; Japan; California

Plants belonging to the genus Salacia in the Hippocrateaceae family are known to inhibit sugar absorption. In a previous study, administration of Salacia reticulata extract in rats altered the intestinal microbiota and increased expression of immune-relevant genes in small intestinal epithelial cell...